PubMed Health⌕ Search

Biomedical subjects

J Toczołowski

Publications and source records attributed to J Toczołowski.

At least 19 recordsLinked to original sources
PubMed1992

Thirty years after the creation of cryoophthalmology.

Low temperatures in ophthalmology were first applied in the end of the previous century. However, those experiments were not sufficiently documented and were not widely used. So the report concerning the Krwawicz (6) method of the cataract cryoextraction published in 1960 is commonly treated as the beginning of the modern cryoophthalmology. This extremely effective and simple method very quickly met with approbation and became commonly applied. After the surgical exposure of the opacificated lens the copper cryoextractor frozen to about -72 degrees C was applied to it. The deep lens freezing to the apparatus occurred enclosing the subcapsular masses. Then the fibres of Zinn ligament were broken and the cataract was gently removed. Due to its safety and the lack of complications the above technique led the real revolution in the cataract surgery. Its was compared to the epochal contribution of Daviel who was the first to remove the lens in 1774. Its importance however, was not just limited to the improvement of the surgical technique. Thanks to the cryoextraction the possibilities of the low temperature application in medicine were noticed. In a short period of time low temperatures began to be used in some other specialties: laryngology, neurosurgery, oncology, etc. It was found out that great number of the eye diseases could be treated in that way, including viral keratitis, haemorrhages to the vitreous, glaucoma, etc. The gradually gained experience gave rise to the new branch of ophthalmology called cryoophthalmology.

Cataract Extraction↗
PubMed1992

[Effect of drugs inhibiting the formation of hydroxide radicals on healing of experimental corneal ulcer].

The 60 per cent water solution of dimethyl sulfoxide (DMSO) was used in the investigations. It was instilled into the conjunctival sac of an eye with experimental corneal ulceration. The dimethyl sulfoxide is inhibiting the formation of hydroxide radicals which cause a damage of the tissue in the course of inflammation. Clinical observations as well as histochemical and histopathological examinations showed that ulcerations treated by dimethyl sulfoxide healed faster than those from the control group and reactions to acid mucopolysaccharides++ returned more rapidly to normal values.

Animals↗
PubMed1991

[Effect of drugs inhibiting prostaglandin activity on the appearance of leukocytes in the tears after experimental injury to the corneal epithelium].

The investigations were carried out on 3 groups of rabbits in which the corneal epithelium was removed and into the conjunctival sac were instilled drugs inhibiting the activity of prostaglandins such as indomethacin solution or a 0.5 p.c. solution of ibuprofen. It was demonstrated that these drugs lead in the period of the first 8 hours to reduction of the number of leucocytes in tears from 2 to 20 times in comparison with the control group. The presented observation show that prostaglandin inhibitors may be a successful mean leading to decrease of number of leucocytes in tears after corneal injury.

Animals↗
PubMed1991

[Experimental studies of retinal ultrastructure after administration of highly fluorinated alkane into the vitreous body].

In experimental investigations the hydrogen-fluoroalkane was introduced into the rabbit vitreous and subsequently the retina was examined in the electron microscope. The observations were carried out in 1, 4 and 8 weeks after introduction of the compound. It was demonstrated that the fluoroalkane penetrated into the internal retinal layers. These layers showed the presence of macrophages, the cytoplasm of which indicated the absorption of the compound. The structure of the retina was preserved till the end of the observation. The compound did not exert any toxic action.

Alkanes↗
PubMed1989

[Comparative studies of the effects of fly ash, soil dust and clay on selected structures of the visual system of female albino rats].

Observations were carried out on 65 white she-rats. The animals received by+intraconjunctival+route a suspension of volatile ashes from ventilators of electricity works, a suspension of the soil from the area of the power-houses and a suspension of clay from clay mines. The animals exhibited marginal blepharitis and conjunctivitis appearing in the 3-5 days of investigation. The observations point to pollution of the soil of the power-house area and to the noxiousness of the investigated dusts which should be classified to the category of burdensome dusts.

Air Pollutants↗
PubMed1989

[Our observations concerning the use of low temperature in the treatment of glaucoma].

Cyclocryoapplication in glaucomatous patients is performed since 1983 by the method settled on the basis of results of experimental investigations. Observations concern 174 persons with various forms of glaucoma. Best results were obtained in patients with glaucoma in the course of uveitis, with secondary glaucoma after perforating injuries and after intracapsular cataract extraction. Fewest favourable results were observed in patients with closed angle glaucoma.

Adolescent↗
PubMed1988

[Histological studies and clinical observations of the effect of various types of dust on the organ of vision of small laboratory animals].

For seven days, three times a day, female rats were instilled into their conjunctival sacs suspensions of power plant dusts, soil and clay. Clinically observed were inflammatory changes of the conjunctiva and cyclids margins as well as traumatisation of the corneal and conjunctival epithelia, appearing at different stages on the experiment. Cytoenzymatic examinations indicated disturbances of oxidation and reduction processes, changes in dialysis through physiologic membranes and dissociation of protein synthesis.

Animals↗