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Biomedical subjects

J Tor

Publications and source records attributed to J Tor.

At least 91 records · Page 5Linked to original sources
PubMed1989

HIV-2 in Spain.

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Deltaretrovirus Infections↗
PubMed1989

[Antibodies against HTLV-1 in patients undergoing multiple transfusions].

HTLV-1 is a retrovirus which causes adult T cell leukemia and is transmitted through contaminated blood products. Patients who have received multiple transfusions are therefore at high risk of HTLV-1 infection. Since it has been postulated that 0.5% of Spanish blood donors present HTLV-1 antibodies, we decided to investigate the presence of these in 154 polytransfused patients in Barcelona. We could not demonstrate the presence of HTLV-1 infection in any of the patients although six of them gave positive ELISA results repeatedly. The validity of tests previously used for the detection of HTLV-1 antibodies is discussed and multicentric studies with a wider population sample are suggested in order to establish the real incidence of HTLV-1 infection in our community.

Blood Transfusion↗
PubMed1988

Asymptomatic HIV.

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Acquired Immunodeficiency Syndrome↗
PubMed1988

[Neurophysiological and therapeutic evaluation of stiripentol in epilepsy. Preliminary results].

The main objective of this study was to determine whether stripentol (STP) alleviates side-effects commonly observed in treated epileptic patients, since preliminary data suggested a positive psychotropic effect. A secondary objective was an evaluation of drug efficacy. Eleven patients with either a drug-resistant epilepsy or toxic effects of AEDs completed the study. Ten had symptomatic partial epilepsies and one an idiopathic generalized epilepsy. STP was added to the baseline therapy (1 or 2 AEDs) and the dose of the baseline AEDs was reduced to maintain plasma levels unchanged (mean reduction: PB 26%, PHT: 49%, CBZ: 38%). Several motor, perceptual and attention tasks and the Washington Psychosocial Seizure Inventory were performed before and after STP administration. Seizure frequency and clinical side-effects were evaluated during a baseline period and after two months of constant therapy. Effects of repeated administration of the neuropsychological battery were assessed by administration of the battery on two occasions at 12-week interval to a randomized subgroup of patients. No practice effect was observed. A trend of improvement (p less than 0.05) in the performance of two tasks requiring sustained attention was noted. Previous side-effects (mainly drowsiness) decreased or disappeared in 7 of 9 patients who became more alert. Six of the nine uncontrolled patients experienced a decrease in seizure frequency equal to or larger than 50 per cent.

Adult↗