Orthodontic treatment for TMJ dysfunction.
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Activator Appliances↗
Biomedical subjects
J Tyler
Publications and source records attributed to J Tyler.
Broken wire repair.
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Activator Appliances↗
Comparative activities of amoxycillin, amoxycillin/clavulanic acid and tetracycline against Chlamydia trachomatis in cell culture and in an experimental mouse pneumonitis.
The activity of amoxycillin, amoxycillin/clavulanic acid and two tetracycline antibiotics was investigated against three strains of Chlamydia trachomatis in vitro. McCoy cells were infected and single doses of antibiotic administered 24 h after infection. The percentage of infected cells was calculated at intervals up to 72 h after infection. Amoxycillin and clavulanic acid, alone and in combination, reduced the incidence of inclusion formation of all three strains. Particularly good activity was observed against the laboratory-adapted strain C. trachomatis Sa2f and a clinical isolate C. trachomatis LB1, where a progressive reduction in numbers of inclusions was observed with time. Minocycline and oxytetracycline were the most active agents tested. In an experimental animal model, mice were inoculated intranasally with C. trachomatis MoPn (ATCC VR123) which caused a fatal pneumonia within 16 days, and treated orally for four days commencing at 24 h after infection. At doses producing clinically achievable serum concentrations, amoxycillin (10 mg/kg), amoxycillin/clavulanic acid (10 + 5 mg/kg) and minocycline (5 mg/kg) all protected the mice over a 21-day period. The majority of the animals treated with clavulanic acid alone (20 mg/kg) survived the infection. Treatment with oxytetracycline was less effective, a dose of 160 mg/kg being required to protect 70% of the mice. The results indicate that amoxycillin and amoxycillin/clavulanic acid were more effective against C. trachomatis MoPn in vivo than might be predicted from in-vitro data, suggesting that amoxycillin/clavulanic acid may have potential for the treatment of polymicrobial infections involving C. trachomatis.
Amoxicillin↗
Antigenic homology among gram-negative organisms isolated from cattle with clinical mastitis.
This study examined the degree of serologic homology among mastitis pathogens. Antibodies were raised against the Rc mutant, Escherichia coli O111:B4 (strain J5) and affinity purified against lipopolysaccharide derived from the Ra mutant, Salmonella typhimurium TV119. These antibodies reacted with a battery of unrelated Gram-negative bacteria in whole cell ELISA. Bacteria with strong cross-reactions included a heterologous, smooth E. coli, Salmonella dublin, S. typhimurium, Salmonella newport, and Pseudomonas aeruginosa. Recognition of Klebsiella pneumoniae and Bordetella bronchisepticum was observed, but reactions were weaker than with the other isolates. The reduced recognition of these isolates probably reflects a masking effect of the bacterial capsule and variations in lipopolysaccharide structure. The polyclonal antibody did not recognize a Gram-positive isolate, Staphylococcus aureus. These immunoglobulins were then tested using whole cell ELISA against a panel of bacteria recovered from the mammary glands of cattle with clinical mastitis. Marked reactivity was noted against a variety of Gram-negative pathogens. Gram-positive isolates had lower recognition by Gram-negative core antigen specific immunoglobulin. The results suggest immunization with rough mutant bacteria may have broad application in the prevention of coliform mastitis.
Animals↗
In-office wire repair.
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Activator Appliances↗
Orthodontic screw appliance repair.
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Acrylic Resins↗
Effect of vaccination with the R mutant Escherichia coli (J5) antigen on morbidity and mortality of dairy calves.
A prospective cohort study was undertaken to determine the efficacy of Escherichia coli 0111:B4 (J5) vaccination in dairy calves. Calves on 2 units were vaccinated when they were 2 to 3 days old and 2 weeks later with the J5 antigen or they were left unvaccinated, and were observed during the first 60 days of age for morbidity and mortality. Events recorded were death, the first case of illness, the first sign of a respiratory tract condition, the first sign of diarrhea, and the first treatment. The time to death or to a morbid event was examined as a function of vaccination status, using the Cox model of survival analysis, where serum IgG concentration at 2 to 3 days of age and gender of the calf were included to control confounding. Signs of morbidity in 517 calves were followed, 189 from unit 1 and 328 from unit 2. Vaccination was associated with a 2.15-fold reduction in risk of death on unit 2 (P = 0.042), but with a 2.43-fold increase in risk of death on unit 1 (P = 0.0035). The only association found between vaccination and morbidity was a 1.34-fold reduction in risk of respiratory tract signs for vaccinated calves on unit 2 (P = 0.055). Necropsy results and clinical investigations indicated that calves on unit 1 were poorly nourished and emaciated. Antibodies to J5 2 weeks after vaccination were significantly (P = 0.0002) lower in calves on unit 1 than in calves on unit 2. The findings offered a possible explanation for the adverse vaccination effect in calves on unit 1.(ABSTRACT TRUNCATED AT 250 WORDS)
Animals↗
Orthodontic soldering on the model.
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Dental Soldering↗
In-office screw appliance repair.
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Acrylic Resins↗
Effect of the MHC on the immunogenicity of vascular allografts in miniature swine.
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Animals↗
A cartilage catabolic factor from synovium.
Porcine synovium in organ culture produces a factor that causes chondrocytes to degrade their matrix. A quantitative assay for the factor, for which the cartilage of bovine nasal septum is used, is described. Evidence is presented that the catabolic factor is a protein.
Animals↗
Diabetic ketoacidosis following glucagon therapy in acute pancreatitis. A case report.
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Acute Disease↗
History of paraplegia.
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Adaptation, Psychological↗
Synthesis of E colicins in Escherichia coli.
Mitomycin C treatment of Escherichia coli cells containing one of the ColE plasmids results in specific inhibition of chromosomal protein synthesis and a high rate of protein synthesis from about 35% of the plasmid genome, whereas similar treatment of plasmid-free cells has no measureable effect on protein synthesis. In the case of ColE2- and ColE3-containing cells, the antibiotic colicin protein (molecular weight about 78000) and two others (molecular weight about 11000 and 6000) are coordinately synthesized in the approximate molar ratio 1:4:1, while in ColE1-containing cells only the colicin protein is synthesized in large amounts. Partially purified colicin E2 isolated from the outer cell surface is associated with the two small proteins in the approximate molar ratio 1:1:1, indicating that not are they only synthesized coordinately but are released as a ternary complex.
Cell Survival↗