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Biomedical subjects

J U Krainick

Publications and source records attributed to J U Krainick.

At least 19 recordsLinked to original sources
PubMed1996

[Flupirtine in comparison with chlormezanone in chronic musculoskeletal back pain. Results of a multicenter randomized double-blind study].

METHOD: The analgesic and muscle-relaxing properties of flupirtine maleate, chlormezanone and placebo were compared in a total of 184 patients. Of these patients, 164 met the criteria of the treatment plan (intention to treat), and the data of 140 patients were finally evaluated in accordance with the test protocol. A positive response was defined as a reduction in pain intensity and muscle tension by 2 categories on the 5-category verbal scale "very severe/severe/moderate/mild/ none" on the seventh day of treatment. RESULTS: In the per-protocol-analysis the responder rate was 60.9% for flupirtine, 47.8% for chlormezanone, and 43.8% for placebo, the difference between drugs and placebo not being significant. The overall assessment of the physicians involved was very good/ good in 47.8% and satisfactory in 37.0% of the flupirtine group, very good/good in 45.6% and satisfactory in 17.4% of the chlormezanone group, the corresponding figures for the placebo group being 33.4% and 20.6%, respectively. Flupirtine was thus superior to placebo (p = 0.007). The incidence of adverse drug reactions was 14.8% (8/54) for flupirtine, 19.3% (11/57) for chlormezanone, and 7.3% (4/55) for placebo.

Adult↗
PubMed1989

Spinal cord transmission of impulses during high spinal anesthesia as measured by cortical evoked potentials.

Cortical evoked potentials (CEPs) resulting from posterior tibial nerve stimulation could be recorded before, but not during, diagnostic high spinal anesthesia to T2-3 in six patients with chronic pain. In contrast, spinal cord stimulation at T8-9 during high spinal anesthesia resulted in CEPs with reduced peak amplitudes and increased P1 and N2 latencies. Amplitudes of the CEPs evoked by spinal cord stimulation increased with increases in stimulus intensity before and during high spinal anesthesia (N = 3). During spinal anesthesia, higher stimulus intensities were required to evoke CEPs of similar amplitudes as before. Because CEPs evoked by stimulation of the posterior tibial nerve disappeared, but those evoked by spinal cord stimulation did not, it is concluded that spinal anesthesia is a result of blockade of nerve roots, not blockade of neural transmission within the cord. Therefore, diagnostic high spinal anesthesia cannot exclude an origin of pain within the spinal cord.

Adult↗
PubMed1987

Sacroiliac joint arthrodesis for chronic lower back pain.

We report our experience with sacroiliac joint arthrodesis in cases of overt osteoarthritis. Twenty-two operations were performed over a period of 3.5 years and reviewed between 12 and 55 months postoperatively. The clinical picture and diagnostic steps are discussed. We conclude that if the selection of patients is strict we can expect 70% satisfactory results.

Adult↗
PubMed1979

Medial thalamic permanent electrodes for pain control in man: an electrophysiological and clinical study.

In 7 patients with medial thalamic electrodes implanted for relief of chronic pain, clinical observations and electrophysiological recordings showed: (1) Clinically, paresthesia in the pain area and contralateral half of the body was reported as well as some unpleasant side effects. The EEG was not changed during medial thalamic stimulation. (2) Threshold for non-painful and painful perception of electrical stimuli were not significantly raised by contralateral medial thalamic stimulation. (3) After electrical median nerve stimulation, evoked thalamic potentials started after 17 msec. With ipsilateral stimulation the early components (up to 40 msec) showed longer latencies and the late components slightly shorter latencies as compared to the contralateral stimulation. (4) Median nerve evoked cortical SSEPs are not significantly changed either by a 500 msec lasting conditioning stimulation of the dorsal columns or by such stimulation of the medial thalamic structures. A facilitation at about 90 msec was found in the cortical SSEP after medial thalamic conditioning in only one of three patients tested. (5) Visual and auditory evoked potentials can be recorded in the medial thalamus as well.

Electric Stimulation Therapy↗
PubMed1978

Pain perception in man after long term spinal cord stimulation.

Thresholds of non-painful and painful perception for electrical stimuli are not altered significantly during dorsal column stimulation either in the area of induced paresthesia or outside it. After long term stimulation of the dorsal column the thresholds for stimuli are significantly higher within the area of induced paresthesia but not outside it. Median nerve evoked somatosensory cortical potentials are not altered by conditioning or simultaneous DC stimulation. During DCS in three of eight patients only the vibration evoked cortical potentials were attenuated in the early three components of the potential.

Adult↗
PubMed1978

Electrical spinal cord stimulation for spastic movement disorders.

Spinal cord stimulation seems today a promising method to improve spasticity. The experiences of two different clinics (Zürich and Freiburg i.Br.) are reported with long-term assessment up to 28 months. The objective data with measurement of stretch and H reflexes support the clinical results. An experimental study on animals does not permit a definitive explanation, but some hypotheses can be suggested.

Adult↗
PubMed1977

Influence of transcutaneous nerve stimulation (TNS) on acute pain.

Using transcutaneous nerve stimulation (TNS) simple surgical procedures such as tooth extractions and nerve biopsies can be performed without the usual anesthetics. Estimation of threshold and suprathreshold intensities of painful electrical stimuli show no significant change during TNS. Only the threshold for non-painful electrical stimuli is slightly increased. Cortical potentials evoked by electrical peripheral nerve stimulation are not significantly modulated by TNS. Latencies of the early components 0, I--III are unchanged, the amplitudes only slightly reduced. These observations are in contradiction to the 'gate-control' theory of pain.

Acute Disease↗
PubMed1977

Influence of dorsal column stimulation (DCS) on spastic movement disorders.

Dorsal column stimulation in two spastic patients with upper motor neurone disease showed the following effects: 1. The subjective feeling of stiffness decreased. During DCS patients were able to walk longer distances without rest. 2. The ability to perform fast alternating or synchronous "pedal-pressing" foot movements improved by 15%. 3. The threshold of H-reflexes was enhanced up to 12%, and outlasted the end of stimulation by two minutes. 4. The H-reflex amplitude was depressed in relation to intensity and duration of DC-stimulation up to 10 minutes after the end of DCS. 5. A late second facilitatory wave at 300 msec in the curve for H-reflexes conditioned by a short tibial stimulus was inhibited during DCS. Although the hyperexcitability of the H-reflex was dampened significantly during DCS the whole motor disturbance improved only slightly.

Adult↗
PubMed1976

[Methods of pain modulation by electrical stimulation (author's transl)].

Different methods of modulating pain by electrical stimulation are described: (1) Nondestructive transcutaneous nerve stimulation is recommended for neurogenic pain syndromes prior to other procedures (success rate about 30%); (2) The implantation of electrodes on the dorsal columns yields good effects in 65% after careful selection; (3) First results with implantations in deep brain structures are discussed.

Analgesia↗
PubMed1976

[Pain suppression in the trigeminal region by means of transcutaneous nerve stimulation].

On the basis of the gate control theory, an attempt was made to influence acute pain by transcutaneous nerve stimulation (TNS) in the region of the trigeminal nerve. After favorable first results in clinical application, we determined sensation and pain treshold values of teeth in two groups of patients by exactly defined electric stimuli of different degrees. After transcutaneous electro-stimulation of the pertinent ramus of the trigeminal nerve with rectangular stimulating currents, the threshold measurements were repeated. The thresholds were raised by an average 79% as far as sensation was concerned, and by an average 69% as far as pain was concerned.

Analgesia↗
PubMed1975

Spinal cord stimulation in post-amputation pain.

One of the pre-operative screening tests for dorsal column stimulation involves direct acute precutaneous stimulation of the dorsal column. The test simulates the postoperative therapeutic situation, shows the patient's reactions to electrically induced paresthesias and enables physician and patient to evaluate beforehand the degree of pain relief to be obtained with the implant.

Amputation, Surgical↗