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Biomedical subjects

J V Conaglen

Publications and source records attributed to J V Conaglen.

24 records · Page 2Linked to original sources
PubMed1985

Effect of naloxone on the hormone response to CRF in normal man.

Ovine corticotropin releasing factor (CRF) was administered to six normal men and the plasma ACTH and cortisol responses compared with those following the same dose of CRF (200 micrograms) plus the opiate receptor blocker naloxone (20mg). The addition of naloxone was associated with a significant increase in plasma ACTH, cortisol and aldosterone responses. No change was observed in peripheral plasma levels of epinephrine, norepinephrine, arginine vasopressin, angiotensin II or renin activity in response to CRF plus naloxone. It is concluded that endogenous opioid peptides may inhibit the ACTH response to CRF. However the addition of naloxone does not increase the ACTH response to CRF sufficiently to constitute a useful test of pituitary function.

Adrenocorticotropic Hormone↗
PubMed1984

The action of anoxia and cyanide on glycogen breakdown in the liver of the gsd/gsd rat.

Perfusion of normal rat livers under anoxic conditions or the addition of KCN to aerobic perfusions activated phosphorylase and stimulated glycogen breakdown and glucose output. Livers from rats with a deficiency of liver phosphorylase kinase (gsd/gsd) showed a much smaller activation of phosphorylase with anoxia or KCN and produced glucose at about half the rate of normal livers. The increase in phosphorylase a in gsd/gsd livers was insufficient to account for the increase in glucose output. The addition of KCN to normal hepatocytes, activated phosphorylase and stimulated glucose output almost as effectively as glucagon. Hepatocytes from gsd/gsd rats showed only a very small increase in phosphorylase a on the addition of KCN, and glucose output did not increase. We conclude that in the perfused liver, anoxia and KCN stimulate glycogen breakdown and glucose output, at least in part, by a mechanism that does not involve conversion of phosphorylase b to phosphorylase a. In isolated hepatocytes KCN stimulates glucose output only by increasing the content of phosphorylase a.

Animals↗
PubMed1984

The effect of ovine corticotropin-releasing factor on catecholamine, vasopressin, and aldosterone secretion in normal man.

The 41-residue ovine corticotropin-releasing factor (CRF) was administered iv to five normal men. A significant rise in plasma corticotropin (ACTH), cortisol, and aldosterone was demonstrated after a dose of 200 micrograms. There was no demonstrable change in supine blood pressure, pulse rate, plasma vasopressin, renin, catecholamines, insulin, glucagon, or glucose. It is concluded that 200 micrograms ovine CRF stimulates ACTH and cortisol secretion independently of any change in peripheral plasma levels of vasopressin and catecholamines. The cortisol and ACTH responses to ovine CRF were less marked but more prolonged than those after insulin-induced hypoglycemia. The relatively small increment in plasma ACTH, which was well within the physiological range, was associated with a significant increase in plasma aldosterone. Posterior pituitary function was not affected by this dose of ovine CRF.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

The effect of gynecological surgery on sexual desire.

This study compared the impact of surgery on sexual desire in women who had undergone hysterectomy with women whose nongynecological surgery was of a similar status. Women aged 30 to 65 completed mailed questionnaires including the Sexual Desire Questionnaire, Hurlbert Index of Sexual Desire, and the Sexual Desire Inventory. Other areas assessed were affect, mood awareness, sexual anxiety, and androgen levels. Analysis of the questionnaire measures showed no differences in sexual desire for gynecological versus nongynecological surgery, or across the different types of hysterectomy. There was no relation between the level of androgens and the women's sexual desire levels. The implications of these findings are discussed with regard to the potential impact of surgery on sexuality, as well as future research in the area.

Adult↗