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Biomedical subjects

J V Felicetta

Publications and source records attributed to J V Felicetta.

8 recordsLinked to original sources
PubMed1992

A dose-response trial of once-daily diltiazem.

This trial was performed to determine the safe and effective dosage range of once daily diltiazem (diltiazem CD) capsules for treatment of essential hypertension. Patients with essential hypertension having supine diastolic blood pressure values greater than or equal to 95 mm Hg and less than or equal to 110 mm Hg were randomly assigned to receive placebo or one of four doses of diltiazem CD: 90, 180, 360, or 540 mg. Blood pressure was measured at trough, 24 hours after the dose, and at the time of peak effect, 10 hours after the dose. Diltiazem CD lowered both supine diastolic and systolic blood pressure. A linear dose response was seen with changes in diastolic and systolic blood pressure and heart rate for trough and peak measurements. Trough/peak ratios for the 180, 360, and 540 mg doses were all greater than 0.50. Adverse effects were dose related; those most commonly reported were headache (8.6%), bradycardia (8.1%), and edema (7%), with bradycardia and edema possibly dose related. It is therefore concluded that diltiazem CD is a safe and effective antihypertensive agent.

Adolescent↗
PubMed1991

Evaluating arthritic complaints.

Adults with arthritic conditions are seen frequently in primary care clinics. However, more than 100 different entities can produce joint and muscle symptoms, which makes it challenging to correctly diagnose musculoskeletal complaints. There are several logical steps to follow in assessing joint disorders. The first is to differentiate between what is and what is not arthritis. Additional steps necessary for an appropriate diagnosis include analysis of a thorough history, physical examination, and laboratory and X-ray results. It is of critical importance to identify the most common forms of arthritis, as well as the specific conditions that require immediate referral. The onset, incidence, findings and pathophysiology of the following entities in the adult population are discussed: septic arthritis, osteoarthritis, rheumatoid arthritis, the crystal-induced diseases, human immunodeficiency virus (HIV) and arthritis, the seronegative spondyloarthropathies and systemic lupus erythematosus.

Adult↗
PubMed1990

When to worry about hypoglycemia.

The important causes of hypoglycemia unrelated to known diabetes are relatively few. Postprandial hypoglycemia is a relatively benign disorder. Fasting hypoglycemia is more serious and may be caused by metabolic disturbances or tumors. Several hereditary disorders cause hypoglycemia in infants and must be diagnosed and treated before serious damage occurs. A systematic clinical approach increases the likelihood of making the correct diagnosis in a timely fashion.

Fasting↗
PubMedDate not supplied

Hypothyroidism: a comprehensive review.

Hypothyroidism is a common clinical entity encountered frequently in most adult primary care settings. The reported prevalence in the general population is approximately 3% in men, but as high as 10% in women (Sawin, Geller, Hershman, Castelli, & Bacharach, 1989). The disease process affects every major organ system, contributing to a broad range of symptoms. Clinicians need to be familiar with the signs, the symptoms, and the appropriate laboratory studies, so that timely and accurate diagnoses can be made. This article reviews normal thyroid physiology and thyroid pathophysiology, as well as the diagnosis and treatment of several important clinical entities resulting in hypothyroidism. Research findings are included insofar as they relate to current clinical practice.

Humans↗
PubMedDate not supplied

Hyperthyroidism: a comprehensive review.

Hyperthyroidism is an endocrine disorder encountered in adult primary care clinics. This article reviews normal thyroid physiology as well as the pathophysiology, diagnosis, clinical signs and symptoms, and diagnostic tests and treatment for the most common clinical hyperthyroid entities. Current research is also discussed as it relates to clinical practice.

Humans↗