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J V Levy

Publications and source records attributed to J V Levy.

52 records · Page 3Linked to original sources
PubMed1970

Effect of organic nitrates on myocardial oxygen consumption in vitro.

1. Mannitol hexanitrate (MANHN), iditol hexanitrate and sorbitan tetranitrate, all at 442 muM, stimulate oxygen uptake by isolated rabbit atrial tissue.2. At the same concentration, glyceryl trinitrate decreased oxygen uptake, while isosorbide dinitrate and erythrityl tetranitrate had no effect.3. No simple correlation was found between the lipoid solubility or per cent nitration of these compounds and their effects on oxygen uptake.4. The stimulating effect of MANHN and its possible role as an uncoupler of oxidative phosphorylation is discussed.

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PubMedDate not supplied

Cardiotonic effects of reduced sulfhydryl amines after preservation of rabbit hearts.

This investigation was designed to examine the role of glutathione and other reduced sulfhydryl amines during reperfusion of the ischemic rabbit heart. To identify the biochemical features of reduced sulfhydryl amines contributing toward improved myocardial function, we investigated several chemical agents sharing a common property with glutathione (L-leucine, L-glycine, ascorbate, oxidized glutathione, L-cysteine). After a period of 24-hour hypothermic storage of the rabbit heart in a modified University of Wisconsin solution containing polyethylene glycol, the hearts were functionally evaluated on a Langendorff working heart model. The agents were then injected as a bolus (60 mumol/L) during reperfusion, and coronary flow and aortic output were measured. Control hearts were untreated. Reduced sulfhydryl amines (glutathione, L-cysteine) significantly improved coronary flow (p < 0.005) and cardiac output (p < 0.005). Ascorbate, L-leucine, L-glycine, and oxidized glutathione all failed to influence cardiac function.

Animals↗