[Hemostasis-altering drugs and techniques for regional anesthesia and analgesia: safety recommendations].
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Biomedical subjects
Publications and source records attributed to J V Llau Pitarch.
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New developments--in the form of emerging clinical settings for regional anesthesia as well as problems arising with the concomitant use of regional techniques and hemostasis-altering drugs--require the ongoing revision of safety guidelines. The annual meeting of ESRA held in Spain in 2003 saw the discussion and clarification of a variety of issues of current concern, including conclusions reached on the estimated risk of spinal hematoma when published safety guidelines are followed or not, precautions to take in epidural anesthesia during cardiac surgery, guidelines for using fondaparinux for thromboprophylaxis, the circumstances under which neuroaxial techniques can be used safely in patients under the effects of platelet aggregation inhibitors such as thienopyridine, and the application of epidural anesthesia in parturients with eclampsia who have received platelet aggregation inhibitors. Conclusions drawn at the meeting enrich and clarify certain important safety issues related to local and regional anesthesia in patients receiving antiplatelet drugs and/or anticoagulants.
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Aprotinin is a protease inhibitor of interest for its antifibrinolytic effect of reducing perioperative bleeding in certain types of surgery, with wide use in heart surgery, liver transplantation and vascular surgery. The application of aprotinin during orthopedic surgery has recently been suggested. Such use is controversial, as there is lack of consensus as to the type of patient for whom aprotinin administration would be indicated, the surgical procedure during which it would be most effective (hip or knee arthroplasty, spinal arthrodesis, major tumor or septic surgery), the doses to administer, its safety and its real efficacy for conserving homologous blood. That is to say, there is no agreement as to the cost/benefit relation of aprotinin for the various types of orthopedic surgery. This critical review of the literature leads to the conclusion that aprotinin is a promising drug for use in orthopedic surgery, given that published studies have established the benefit in blood product savings and decreased blood loss during surgery.
OBJECTIVE: To determine the packed red cell transfusion practices of Spanish anesthesiologists and the importance they placed on techniques for reducing blood product use. MATERIAL AND METHODS: One hundred letters with five copies of a questionnaire were sent to an equal number of anesthesiology and intensive care recovery departments of randomly chosen Spanish hospitals. RESULTS: Forty-seven hospitals responded with 208 completed questionnaires. Responses following the questionnaire form were considered valid. Transfusions are regularly given when hematocrit falls 24% (39.4%) or 27% (37.8%) or when hemoglobin falls below 8 g% (37%) or 9 g% (30%). Most respondents considered that certain clinical situations can affect the need for transfusion: age (86.5%), coexistence of heart disease (95%) or respiratory disease (72.3%) and prior hematocrit or hemoglobin levels (88%). The most frequently applied technique for reducing the need for blood product transfusion of blood derivatives is normovolemic hemodilution, followed by autologous self-transfusion and controlled hypotension. Clinical judgement and prior blood test results are highly valued as indicators for transfusion (8.68 and 7.48 points out of 10, respectively). The respondents suggested the need for greater coordination of medical and surgical department transfusion policy, as well as the need to hold a consensus conference. CONCLUSIONS: Perioperative transfusions of packed blood cells are mainly performed at 8 to 9 g% of hemoglobin, although need is often based on certain clinical features.