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Biomedical subjects

J V Lustig

Publications and source records attributed to J V Lustig.

10 recordsLinked to original sources
PubMed1984

Childhood asthma. Considerations in establishing treatment programs.

This article briefly discusses the natural history of asthma, evaluation strategies, patient education programs for asthmatics and their families, as well as monitoring techniques for outpatient management of the asthmatic child. This information should facilitate an aggressive comprehensive treatment program that will not only minimize symptomatic periods but maximize normalization of the patient's life-style.

Acute Disease↗
PubMed1982

Increased child abuse in families with twins.

Large families and inadequate spacing of children increase the risk of abuse. Twin births incorporate both of these factors, yet the association of twinning with subsequent abuse has not been explored. Forty-eight families with twins from St Vincent Hospital and Medical Center and Nashville General Hospital were compared with 124 single-birth families, matched for hospital of delivery, birth date, maternal age, race, and socioeconomic status. Three control (2.4%) and nine twin (18.7%) families were reported for maltreatment (P less than .001). Mothers of twins experienced greater previous parity than did control subjects (P less than .001). Twins also had significantly longer nursery stays (P less than .001), lower birth weights (P less than .001), and lower Apgar scores at one (P less than .01) and five (P less than .05) minutes. A regression analysis incorporating all of these variables, however, showed that twin status was most predictive of subsequent abuse.

Adult↗
PubMed1977

Reconstitution of T-cell function in severe combined immunodeficiency disease following transplantation of early embryonic liver cells.

In a 51/2-month-old male infant with adenosine deaminase-positive severe combined immunodeficiency disease, who had no suitable bone marrow donor, immunologic reconstitution was attempted with lymphoid cells obtained from the liver of a 4- to 5-week-old-male human embryo. A mild graft-versus-host reaction began three weeks later. T-cells, which were absent prior to infusion of hepatic lymphoid cells, rose to a maximum of 554/mm3 at 16 weeks post transplantation. A normal lymphocyte response to pokeweek mitogen was not present until 25 to 30 weeks and to allogeneic cells until 39 weeks. Postive in vitro lymphocyte responses to Candida albicans were found repeatedly after 52 weeks. Twenty months following transplantation the patient is free of clinical infection, although he requires regular injections of gamma globulin.

Child, Preschool↗
PubMed1976

Immunologic function of patients with chronic benign lymphadenopathy.

Three children with chronic lymphoid hyperplasia and hypergamma-globulinemia are presented. They had normal numbers of circulating T-cells and normal in vitro lymphocyte responses to phytohemagglutinin and specific mitogens. The number of cells staining for surface immunoglobulins was decreased in two patients but increased in one patient with chronic lymphocytosis which is still present 5 years after his initial hospitalization. Lymphocytes without detectable markers ("Null cells") were increased in all three patients. Levels of antibody titers to common antigens were normal. Lymph node biopsies showed nonspecific hyperplasia of the B-cell areas. The combination of normal immune responses with lymphoid hyperplasia and with a chronic lymphocytosis in one of the children suggests that this syndrome may be due to a defect in the regulation rather than the initiation of immune responses.

Child↗