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Biomedical subjects

J V Pauli

Publications and source records attributed to J V Pauli.

16 recordsLinked to original sources
PubMed1989

An unusual Heinz body anaemia in a cat.

A severe anaemia was diagnosed in a 7-month-old female cat. Most erythrocytes contained unusually large Heinz bodies and showed marked distortion. Six weeks later, the cat had recovered from the anaemia, but the erythrocytes still contained smaller inclusions. By light microscopy, these inclusions did not stain as typical Heinz bodies, but, by electron microscopy, Heinz bodies and autophagocytic vacuoles were identified. It is suggested that this cat had a pre-existing defect in its haemoglobin which made it more susceptible to damage by an unknown oxidizing agent.

Anemia, Hemolytic↗
PubMed1989

Familial progressive nephropathy in young Bull Terriers.

The clinical, clinicopathological and pathological findings are described in three Bull Terrier bitches with advanced renal disease. The bitches were less than four years old and showed variable presenting signs but anorexia, lethargy and polydipsia were the most frequent. All three dogs were azotaemic and isosthenuric. Urinary protein was measured in two of the three cases. Both were proteinuric. At necropsy all dogs had shrunken kidneys. Histological examination revealed nephron loss, atrophy of glomerular tufts, interstitial fibrosis, and mineralisation of basement membranes. The progressive renal disease in these dogs was similar to the condition reported in Bull Terriers in Australia, and is probably familial and inherited.

Journal Article↗
PubMed1985

Magnesium concentrations in the ventricular and lumbar cerebrospinal fluid of hypomagnesaemic cows.

Samples of ventricular and lumbar cerebrospinal fluid (CSF) were taken at intervals from six lactating dairy cows, made hypomagnesaemic by feeding a magnesium-deficient diet. Initially the ventricular CSF had a higher magnesium concentration than lumbar CSF but as the cows became hypomagnesaemic the magnesium concentration in ventricular CSF decreased more rapidly than that in lumbar CSF. Tetany occurred when the concentration of magnesium in ventricular CSF fell below about 0.5 mmol litre-1. Intravenous infusion of magnesium into two hypomagnesaemic cows increased the concentration of magnesium in ventricular CSF before there was any change in the lumbar CSF. Newly formed CSF from the ventricles appeared to be more sensitive to changes in the concentration of magnesium in plasma than lumbar CSF which equilibrates with the diffusible magnesium of the central nervous system.

Animals↗
PubMed1984

Intestinal lymphangiectasia in a dog.

An eight-month-old female crossbred terrier was presented with a short history of diarrhoea, dyspnoea and abdominal distension. Clinical examination revealed thoracic effusion, ascites, and subcutaneous oedema. Hypoalbuminaemia, hypoglobulinaemia and lymphopaenia were all present. Histological examination of a jejunal biopsy confirmed a diagnosis of intestinal Iymphangiectasia. Full clinical recovery followed treatment by dietary management.

Journal Article↗
PubMed1983

Colostral transfer of gamma glutamyl transferase in lambs.

Serum gamma glutamyl transferase (GGT) levels in blood samples taken from normal lambs which had suckled colostrum were found to be up to 140 times normal adult levels. These high serum levels declined rapidly reaching a stable level approximately 60% higher than normal adult values by 24 days of age. Newborn lambs which had not yet consumed colostrum had GGT levels which would be considered normal in adult sheep. The GGT concentration in ewes' colostrum was up to 470 times normal serum levels. There was a significant positive correlation between serum GGT and gamma globulin levels in blood samples taken from lambs within 24 hours of birth. Lambs' serum alkaline phosphatase (AP) and serum glutamate oxaloacetate transaminase (SGOT) levels also rose concurrently with the absorption of colostral gamma globulin, with the day 1 AP values being significantly correlated with the serum gamma globulin levels. Serum AP levels declined gradually but were still well above normal adult levels at 45 days of age while SGOT levels returned to normal adult levels by two to three days after birth. It is concluded therefore that, as previously shown in calves, lambs acquire high levels of serum GGT activity from their mothers' colostrum in proportion to the amount of gamma globulin absorbed and also show a concurrent rise in serum AP activity. However the rise in SGOT levels at this time has not been observed in calves.

Journal Article↗
PubMed1982

Blood constituents of farmed red deer (Cervus elaphus): I. Haematological values.

Approximately 100 farmed male and female red deer aged three months and over were blood-sampled and haematological parameters were measured. The deer were sampled by jugular venepuncture without tranquilization. Mean values were haemoglobin (16.0 g/dl), packed cell volume (44.6%), mean corpuscular haemoglobin concentration (35.8 g/dl), total plasma protein (66.0 g/l). fibrinogen (4.8 g/l) and white blood-cell numbers (5.80 x 10(9)/l). Differential white blood-cell counts were neutrophils (53.9%), eosinophils (4.8%), basophils (3.0%), lymphocytes (37.2%) and monocytes (1.1%). There were no significant differences in any parameter measured between sexes or between age groups three to eight months, nine to eighteen months, or older.

Journal Article↗
PubMed1981

Colostral transfer of gamma glutamyl transpeptidase in calves.

Serum gamma glutamyl transpeptidase (GGT) levels in blood samples taken from normal calves which bad suckled colostrum were much higher than those found in healthy adult cattle. Levels of over 60 times the normal adult level were observed. These high levels of GGT took approximately 5 weeks to decline to adult values. Calves which appeared to have not received or absorbed colostrum had GGT levels which would be considered normal in adult cattle. A calf with serum gamma globulin levels which indicated an intermediate amount of colostrum absorption had a level of GGT which was intermediate between that expected for normal adult cattle and that found in calves which had more fully absorbed colostrum. The mean GGT level observed in colostrum from 6 newly-calved cows was over 800 times the mean serum GGT level of the same 6 cows. It therefore appears most likely that GGT is concurrently absorbed with colostrum by calves and this gives rise to the very high levels seen in normal calves. Calves with very high levels of serum GGT also had raised levels of alkaline phosphatase (AP) which slowly declined but never reached normal adult levels within the 53-day period of observation. It therefore appears that high levels of both GGT and AP are achieved by calves at the time of colostrum absorption and it is concluded that clinical interpretation of serum GGT and AP levels in young calves is closely dependent upon parallel knowledge of their serum gamma globulin levels.

Alkaline Phosphatase↗
PubMed1975

Responses to the lowering of magnesium and calcium concentrations in the cerebrospinal fluid of unanesthetized sheep.

A technique for ventriculolumbar perfusion of the cerebrospinal fluid space has been used to study the neuromuscular effects of low concentrations of magnesium and calcium in the cerebrospinal fluid of conscious sheep. Perfusion with synthetic cerebrospinal fluid solutions containing less than 0-6 mg magnesium/100 ml produced episodes of tetany which were abolished by perfusion with a solution of normal magnesium concentration. This suggests that the low cerebrospinal fluid magnesium concentrations reported in cases of hypomagneseamic tetany may result in changes within the central nervous system that could produce the nervous signs. Perfusates with a calcium concentration below 2-0 mg/100 ml caused hyperpnoea and continuous muscle tremors. Magnesium (0-6 mg/100 ml) and calcium (2-0 mg/100 ml) perfused simultaneously acted synergistically to produce signs characteristic of low levels of each of the ions.

Animals↗
PubMedDate not supplied

Blood constituents of farmed red deer (Cervus elaphus). II: biochemical values.

Approximately 80 farmed male and female red deer aged three months and over were blood sampled and biochemical parameters measured. The deer were sampled by jugular venepuncture without tranquillization. Mean values recorded were serum gamma-glutamyltransferase (19.5 IU/l), glutamic oxaloacetic transaminase (43.0 IU/l), creatine phosphokinase (197.9 IU/l), plasma pepsinogen (0.91 IU/i), blood urea nitrogen (8.56 mmol/l), serum glucose (6.9 mmol/l), phosphorus (1.75 mmol/l), calcium (2.13 mmol/l), magnesium (0.74 mmol/l), potassium (4.43 mmol/l) and sodium (138.5 mmol/l). There were no significant differences in any parameter between sexes or between age groups 3-8 months, 9-18 months, or older.

Journal Article↗
PubMedDate not supplied

One-stage prothrombin times and subcutaneous haemorrhagic speckling in lambs.

The one-stage prothromhin times of 100 lambs from ten different farms varied from 13 to 24 seconds with a mean of 16.6 seconds. The extent and severity of subcutaneous haemorrhagic speckling of carcases was assessed in 775 animals from the same farms and the prevalence of this lesion was similar to that found at the same works during the 1977/78 season. The means of both one-stage prothrombin times and speckling varied significantly between groups of lambs from different farms but there was no statistical association between the prevalence of speckling and the one-stage prothrombin times.

Journal Article↗