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Biomedical subjects

J V Reyniak

Publications and source records attributed to J V Reyniak.

14 recordsLinked to original sources
PubMed1979

Serum prolactin levels in short-term and long-term use of inert plastic and copper intrauterine devices.

Serum prolactin values were assessed in 59 normally menstruating parous women; groups were divided with respect to short-term (6 weeks) and long-term (4-60 months) use of either the inert plastic IUD (Saf-T-Coil or Lippes Loop) or copper IUD (Cu-7). Preinsertion values served as controls in the short-term study while a separate control group using barrier contraception was used in the long-term study. Prospective analysis of short-term IUD use and retrospective analysis of long-term IUD use revealed no significant differences in mean hPRL compared to control values. Both short- and long-term mean values were within the normal range for serum hPRL. In addition, duration of use had no significant effect on hPRL values.

Adolescent↗
PubMed1979

Transverse vaginal septum.

Transverse vaginal septum, perhaps the most common congenital anomaly of the vagina, is nonetheless an unusual finding. A case report and its management and theories concerning the embryology of the vagina are presented. The varying presentations of imperforate versus perforate transverse septa are reviewed, as well as diagnostic tools and treatment modalities. Surgical excision of the septum is advocated.

Adult↗
PubMed1979

Endocrine physiology of the breast.

Endocrine physiology of the breast is discussed in regard to both the development and functional aspects. The interaction of hormones at the mammary gland level is presented from the fetal stage through the reproductive era. The mechanisms of galactopoiesis and lactation are discussed. Finally, physiology of prolactin and the influence of this hormone upon the breast in physiologic and pathologic states is presented.

Breast↗
PubMed1978

Immune infertility and new approaches to treatment.

A number of patients who have involuntary infertility show sperm antibodies in the blood serum, as detected by two quite different methods of spermagglutination. These techniques are the Kibrick method (gelatin agglutination test) and the F-D method (tube-slide agglutination test). By the former technique, the sera of 18% of women and 9% of men from infertile couples were found to be positive; by the latter technique, the sera of 15% of women and 5% of men were positive. Such cases are termed "immunologic infertility." In an effort to develop new methods for the treatment of infertility, two procedures were explored. One is a sperm washing insemination method in which fresh semen from a man with the antibody is centrifuged, resuspended in an albumin solution, and then used for insemination. The second is an immunosuppression method, using methylprednisolone at a dose of 96 mg/day for 7 days. A striking decrease in antibody level was seen in some cases, with ensuing pregnancy. The success rates for these methods have been of the order of 14% to 22%.

Antibodies↗
PubMed1978

Microsurgical anastomosis of the rabbit oviduct using 9-0 monofilament polyglycolic acid suture.

As part of a larger study to determine which factors are important in fallopian tube reconstruction, 9-0 monofilament polyglycolic acid suture on a 145 micron-needle was used for rabbit oviduct microsurgical anastomosis. A 100% pregnancy rate in five rabbits with no disruption of the endosalpingial or muscular layers was noted. Of special note, the suture was totally resorbed, and no suture residuum or surrounging reaction was noted. The suture material appears to fulfill the criteria for an ideal suture described at the beginning of the paper. This is the first report of the use of a 9-0 monofilament polyglycolic acid suture.

Animals↗
PubMed1978

Antibodies to spermatozoa. VIII. Correlation of sperm antibody activity with postcoital tests in infertile couples.

A study of the correlation between results of postcoital tests (PCTs) and presence of sperm antibodies in sera of either male or female partners or in the cervical mucus of seminal plasma, was made in 127 infertile couples. The percentage of positive antibody tests increased progressively as PCT results deteriorated from excellent to poor. Thus, the percentage of positive serum tests, by either method used, was 7% in the excellent group as compared to 52% in the poor group. This progressive increase was evident only in the females; the antibody tests in the males did not correlate directly with the PCT results. Nonetheless, even with excellent PCT results, 7% of women and 21% of men showed presence of antibodies. On the other hand, in the group showing poor PCTs, 48% of women had an absence of antibodies.

Adult↗
PubMed1977

The effect of conjugated estrogens on coagulability in menopausal women.

To investigate the effect of conjugated equine estrogens on the coagulability in menopausal women, blood samples were drawn from 69 menopausal females--35 receiving estrogens and 34 receiving no replacement therapy. Using tests for antithrombin and heparin-antithrombin activities, 14.7% of the control patients were found to be hypercoagulable. This is a 289% increase in the incidence of hypercoagulability in the group treated with estrogens. The particular relevance of this finding to menopausal women and the importance of the use of the coagulation profile in managing such patients is discussed.

Adult↗
PubMed1976

Dysfunctional uterine bleeding.

The etiology and pathogenesis of dysfunctional uterine bleeding are discussed. For both age groups, adolescents and perimenopausal women, gonadotropin-steroid patterns as well as endometrial changes are presented. Methods of evaluation and therapy are described, including curettage and judicious of estrogen-progestogen combinations. Finally, long-term follow-ups of these patients are presented, with plans for reevaluation as well as palliative treatment based on the bleeding patterns and gonadotropin levels.

Adolescent↗
PubMed1976

Conservative surgical management of tubal pregnancy.

In an attempt to maintain optimal fertility in the patient treated for midtubal pregnancy, an investigation of conservative surgical procedure was made. The technic developed utilizes tubal excision, reanastomosis, and a single hydrotubation with Dextran. Tubal patency was maintained without the use of stents that may damage the fimbria. The procedure is compared to other conservative technics and its advantages discused. Thus far 2 patients have undergone this excision and reanastomosis, and both patients successfully established intrauterine gestations within 2 months of returning to normal active coital frequency. Both were in the midtrimester of pregnancy at the time of this report.

Adult↗
PubMed1975

Endometrial dating correlated with progesterone levels.

The aim of this work was to document the validity and usefulness of progesterone determination instead of endometrial biopsies as evidence for ovulation within a menstrual cycle. The presence of progesterone in amounts greater than 2 ng/ml of plasma was always associated with a secretory endometrium, ie, the endometrium was matured beyond cycle day 14 as diagnosed by classical histologic dating. The remarkable simplicity of quantitating luteal phase progesterone levels by this radioimmunoassay warrants their extended use for evaluating the physiology and the pathology of the corpus luteum.

Biopsy↗
PubMed1975

Endometrial regeneration after voluntary abortion.

Endometrial biopsies were obtained on postabortal days 1 to 36 in 42 women without contraception, in 28 women using oral contraceptives, and in 12 women with intrauterine devices. Tissue samples were examined for day-to-day sequential changes, specifically: a)regenerative, repair, proliferative and secretory activity, b)involution of pregnancy changes, c)inflammation. In the absence of contraception, the endometrium promptly regenerated. The earliest evidence of ovulation was on day 9. One-third of the women ovulated before the first period. Incomplete placental and decidual involution was seen in 45% of patients, but its frequency progressively decreased toward the end of observation. Inflammation seen in 26% was limited to the retained decidua and was, therefore, thought to be a reactive rather than an infectious phenomenon. In women taking oral contraceptives, initial regeneration was also prompt. "On pill" changes resembled the nonpostabortal picture except for a few cases of cystic glandular dilation, or Arias-Stella-like phenomena. Retained decidua and inflammation were more frequent (75% and 68%) than in the noncontraceptive group, and the diminishing trend was not observed. In the intrauterine device group, inflammation was more frequent (83%) than in the other two groups and was not limited to the decidua.

Abortion, Induced↗