Biomedical subjects

J V Solnick

Publications and source records attributed to J V Solnick.

22 records · Page 2Linked to original sources

PubMed1984

Cerebromicrocirculatory defects in animal model of depression.

In the tetrabenazine (TBZ) model of depression, the cerebromicrocirculation was discovered to respond abnormally to metabolic demand as mimicked by the administration of CO2. Altered responsivity of cerebral blood flow and effective permeability of the blood--brain barrier to changes in PaCO2 were found. These physiologic defects coincided temporally with TBZ-induced depletion of central norepinephrine and dopamine and with the development of the behavioral effects of TBZ (the end points used to test the antidepressant potential of experimental drugs). Pretreatment with amitriptyline (a standard antidepressant and amine reuptake inhibitor) prevented the development of these TBZ-induced abnormalities in the cerebromicrocirculation, just as it prevented the behavioral effects.

Amitriptyline↗

PubMed1981

The relationship between parent-youth interaction and delinquency in group homes.

Interactions between the youths and group home parents in 10 group homes were directly observed during a 2-hour session in each home. These observations were compared to questionnaire measures of the youths' self-reported delinquency while in the group home, and their evaluation of the group home program. The results indicated that over the 10 homes there was a strong inverse correlation between mean self-reported delinquency and the average amount of time youths spent taking to (rs = -.95) and in proximity to (rs = -.81) their group home parents. Talking to group home parents also showed a positive correlation with the youths' evaluation of their group home program. Similar trends were found when the correlations were computed over individual youths, although the magnitudes were reduced. These data may have implications for our understanding of the relationship between parenting behaviors and delinquency, as well as for the improvement of group-home treatment programs.

Adolescent↗

PubMed1980

The technical drift of applied behavior analysis.

Four dimensions (applied, analytic, general, conceptual) were selected from Baer, Wolf, and Risley's (1968) seminal article on the nature of applied behavior analysis and were monitored throughout the first 10 volumes of the Journal of Applied Behavior Analysis. Each of the experimental articles in Volumes 1 through 6 and the first half of Volumes 7 through 10 was rated on each of these dimensions. The trends showed that applied behavior analysis is becoming a more purely technical effort, with less interest in conceptual questions. We are using simpler experimental designs and are conducting fewer analogue studies. Although concern for maintenance is increasing, other forms of generality are being measured or analyzed less often. These trends are discussed in terms of a technical drift in applied behavior analysis.

Journal Article↗

PubMed1977

Some determinants of the reinforcing and punishing effects of timeout.

Some determinants of the reinforcing and punishing properties of timeout were investigated in two experiments. Experiment I began as an attempt to reduce the frequency of tantrums in a 6-yr-old autistic girl by using timeout. Unexpectedly, the result was a substantial increase in the frequency of tantrums. Using a reversal design, subsequent manipulations showed that the opportunity to engage in self-stimulatory behavior during the timeout period was largely responsible for the increase in tantrums. Experiment II was initiated following the failure of timeout to reduce the spitting and self-injurious behavior of a 16-yr-old retarded boy. Using a multiple-baseline design, the nature of the timein environment was shown to be an important determinant of the effects of timeout. When the timein environment was "enriched", timeout was effective as a punisher. A conception of timeout in terms of the relative reinforcing properties of timein and timeout and their clinical implications are discussed.

Adolescent↗