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J Vázquez-Doval

Publications and source records attributed to J Vázquez-Doval.

15 recordsLinked to original sources
PubMed1995

Multiple pilosebaceous cysts.

We report two patients initially diagnosed as having steatocystoma multiplex (SM). Other cysts showed characteristics of eruptive vellus hair cyst (EVHC). More than 30 and 14 cysts, respectively, were removed with histological hybrid characteristics of SM and EVHC. This suggests that SM and EVCH are two closely related entities, which represent a naevoid malformation in the area where the sebaceous duct and hair follicle meet.

Adult↗
PubMed1994

Metastatic melanoma of unknown primary tumor.

The appearance of metastasis without clinically demonstrable primary tumor is one of melanoma's challenges. The aim of this study was to recognize the specific characteristics of this occurrence. Based on our study of three patients, we have proposed theories to explain this behavior, its clinical approach, and therapeutic management. We conclude by stressing the importance of finding the primary tumor or traces of it.

Adult↗
PubMed1993

Mucinous nevus.

Explore the source record for details and available documents.

Adolescent↗
PubMed1993

Occult spinal dysraphism: a neurosurgical problem with a dermatologic hallmark.

Lumbosacral congenital cutaneous lesions have been recognized for a long time by neurologists and neurosurgeons as markers of occult spinal defects, but only a few cases have been published and discussed in the dermatologic literature. Based on a case report, we emphasize the importance of early diagnosis of these lesions, the use of new diagnostic techniques, and the correct management.

Child, Preschool↗
PubMedDate not supplied

Subacute cutaneous lupus erythematosus--clinical, histopathological and immunophenotypical study of five cases.

Subacute cutaneous lupus erythematosus (SCLE) is a recently described distinct subset of lupus erythematosus (LE) having characteristic clinical, serological and genetic features. The clinicopathological and serological findings of 5 patients are reported. From a clinical point of view, we describe two types of cutaneous lesions: psoriasiform and annular pattern. ANA were present in 80% of the cases, anti-Ro was present in 60%, and anti-La in 20%; anti-RNP was positive in 1 patient. Circulating immune complexes were detected in 2 patients, and low levels of complement factors (C3, C4) in another 2 patients. The B- cell alloantigens HLA-A2, HLA-Bw4 or HLA-DR3 were present in 60% of the cases. The cutaneous histopathology revealed important changes in the epidermis. Our findings are similar to those described by most other authors. Also, we would like to emphasize the low disease activity and benign course of our patients.

Adult↗
PubMedDate not supplied

Defective mononuclear phagocyte function in systemic lupus erythematosus: relationship of FcRII (CD32) with intermediate cytoskeletal filaments.

To investigate the mechanisms of impaired Fc receptor-mediated mononuclear phagocyte system (MPS) clearance in systemic lupus erythematosus (SLE), we have examined FcRII (CD32) and vimentin function in 25 patients with SLE and 36 healthy adults. In SLE, FcR-mediated phagocytosis of IgG-sensitized bovine erythrocytes was decreased (5.9 +/- 2.47 vs. 8.3 +/- 3.59 erythrocytes phagocytosed/monocyte/h; p < 0.05), and CD32 and vimentin expression was within the normal range; however, the percentage of simultaneously CD32+ and vimentin+ cells was increased (30 +/- 12 vs. 20 +/- 13; p < 0.05). Circulating immune complexes (CIC) were positive in 11 SLE patients, and levels were positively correlated with proteinuria (r = 0.53; p < 0.05) and disease activity (r = 0.40; p < 0.05). The mobility of membrane molecules, measured as the percentage of patients that showed patching and/or capping of CD32, was increased compared with controls, but not significantly (p < 0.1). At the same time, redistribution of vimentin filaments was observed. In conclusion, our data seem to support the possibility of a functional and/or structural alteration in the relationship between Fc receptors and intermediate cytoskeletal filaments as a causative factor in the deficient internalization of ligands bound to Fc receptors in monocytes of SLE patients.

Adolescent↗