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Biomedical subjects

J Valentour

Publications and source records attributed to J Valentour.

5 recordsLinked to original sources

Cocaine in Wayne County Medical Examiner's cases.

We determined the incidence of detection of cocaine or its metabolites in Wayne County (Michigan) Medical Examiner's cases from 1984 to 1987. Over this four-year period there was a significant (P less than 0.01) increase each year in evidence of recent cocaine use in this population, reaching 38.3% of all tested cases in 1987. Much of this increase was accounted for by homicide victims, especially those in their third or fourth decade of life, of whom 58.6 and 56.3%, respectively, tested positive in 1987. There was a large increase in recent cocaine use in teenage homicide victims in 1987, having previously changed little from 1984 to 1986. In victims of drug abuse, recent cocaine use also increased significantly (p less than 0.01) each year, reaching 47.6% in 1987, generally in combination with heroin. Although deaths attributed solely to cocaine were not as common, they also increased significantly each year from 4 in 1984 to 25 in 1987. Compared with the general population, those who use cocaine in Wayne County are more likely than those who do not to die prematurely, often as a result of violence.

Adolescent↗

A hydromorphone and ethanol fatality.

A case report is presented of a fatality where death is attributed to the combined central nervous system-depressing effects of ethanol and hydromorphone. Blood and tissue levels of hydromorphone are reported and the concentrations are compared to previously reported data.

Adult↗

Gas chromatographic analysis of lidocaine in blood and tissues.

A rapid, sensitive, and specific gas chromatographic assay for lidocaine in plasma and blood is reported. The procedure involves a single step extraction of the drug and internal standard, and analysis without derivatization. The method can be modified to include the analysis of lidocaine in tissues.

Chromatography, Gas↗

Liquid chromatographic analysis of thiopental in blood and tissues.

A liquid chromatographic method for the quantitation of thiopental in blood and tissues is presented. Quantitation in blood utilizes a single step dichloromethane extraction at pH 5.5. After mixing and centrifugation, the organic layer is evaporated to dryness at 40 degrees C and the residue reconstituted with methanol. Tissue extraction includes an alkaline clean-up step followed by re-extraction with dichloromethane after acidification. Either of two 10 mu columns can be used: a C8 or a C18 column. The mobile phase was methanol:water (60:40) at a flow of 2 mL/min. The wavelength of detection was 290 nm. Thiopental can be detected to 1 mg/L using this procedure, and no interferences with other acidic or neutral drugs were found.

Chromatography, Liquid↗