Biomedical subjects

J Valero Puerta

Publications and source records attributed to J Valero Puerta.

17 recordsLinked to original sources

PubMed1999

[Granular cell tumor of the scrotum with high pseudoepitheliomatous hyperplasia].

OBJECTIVE: To report a rare case of scrotal granular cell tumor. METHODS: A 19-year-old man presented with a nodule on the scrotum, 2 cm in diameter. It had been present for months and was covered with ulcerated epidermis. The tumor was resected. RESULTS: The histological study disclosed a neoplasm composed of polygonal cells with cytoplasmic granules and pseudoepitheliomatous hyperplasia of the overlying skin. Immunohistochemically, the cells showed a strong positivity for S100 protein and vimentin. The proliferation index (ki 67) was low in its cells, but high in the overlying hyperplasic epidermal cells. CONCLUSIONS: To our knowledge, this is the second case of scrotal granular cell tumor reported. The case described herein has the unique feature of severe overlying pseudoepitheliomatous hyperplasia. S100 positivity supports a neurogenic differentiation.

Adult↗

PubMed1999

[Polypoid eosinophilic cystitis mimicking bladder carcinoma].

OBJECTIVE: To report an additional case of polypoid eosinophilic cystitis mimicking a urothelial carcinoma of the urinary bladder. METHODS: An 81-year-old man presented with hematuria and dysuria that he had noted for the past month. The US findings were consistent with a bladder tumor and consequently the patient was submitted to transurethral resection. RESULTS: Histological analysis disclosed inflammatory infiltrates with numerous eosinophils (eosinophilic cystitis), but no evidence of tumor. The patient is well two years later. CONCLUSIONS: The present case demonstrates that polypoid eosinophilic cystitis can mimick a bladder carcinoma. Histopathological analysis is necessary for the differential diagnosis.

Aged↗

PubMed1999

[Intrascrotal malignant fibrous histiocytoma].

OBJECTIVE: To describe a rare case of intrascrotal malignant fibrous histiocytoma. METHODS: A 90-year-old man presented with a scrotal mass which he had noted during the past few months. A scrotal tumor, 8 cm in diameter, was detected on physical evaluation. Tumor resection was decided due to the patient's good general condition despite his age. RESULTS: The histological analysis confirmed a sarcomatoid neoplasm with pleomorphism. The immunohistochemical analysis demonstrated strong overexpression of vimentin, alpha-1-antichymotrypsin, CD68 (Kpl), p53 oncoprotein and elevated Ki67. The ultrastructural study showed undifferentiated mesenchymal cells. The diagnosis of intrascrotal malignant fibrous histiocytoma was made based on the foregoing findings. CONCLUSIONS: Malignant fibrous histicytoma should be included in the differential diagnosis of intrascrotal tumors. Histological, immunohistochemical and ultrastructural studies are very important to distinguish the different paratesticular sarcomas. The strong overexpression of the p53 oncoprotein may be involved in the pathogenesis of this tumor type.

Aged↗

PubMed1999

[A renal cortical hemangioma simulating a carcinoma].

OBJECTIVE: To report a case of renal cortical hemangioma. METHODS/RESULTS: A 38-year-old patient consulted for recurrent renal colic. The CT scan findings showed a cortical lesion in the right kidney that was compatible with a carcinoma. The patient underwent nephrectomy. Pathological analysis of the surgical specimen showed a 2.7 circumscribed cortical lesion that was found to be a hemangioma. CONCLUSION: Renal hemangioma localized to the renal cortex can mimic a carcinoma.

Adult↗

PubMed1999

[Squamous carcinoma of the male urethra, its presentation as a scrotal abscess].

OBJECTIVE: To report a case of urethral carcinoma presenting as scrotal abscess. METHODS: A 53-year-old man presented with swelling, redness and pain in the scrotum. He had a history of urethral stricture and multiple scrotal abscesses. Incision and drainage were performed and the patient was treated with antibiotics without improvement. Incision and drainage were repeated and a biopsy of the tissue edges of the abscess were performed. RESULTS: Histopathological analysis disclosed a squamous cell carcinoma arising from the urethra. CONCLUSION: Patients with a history of urethral stricture should be followed closely. A scrotal biopsy should be performed in patients who do not improve with antibiotic therapy.

Abscess↗

PubMed1999

[Rapidly metastasizing renal carcinoma with intense expression of p53 and P-glycoprotein].

OBJECTIVE: A case of rapidly metastasizing renal carcinoma is presented. METHODS: A 62-year-old man complained of fever for the past 6 weeks and weight loss. An abdominal CT disclosed two cystic hepatic lesions compatible with hydatid cysts and a mass in the upper pole of the left kidney suggestive of a carcinoma. The patient underwent resection of the kidney. RESULTS: Histopathological analysis demonstrated renal adenocarcinoma with pleomorphic areas. Immunohistochemical analysis showed a high cellular proliferation rate (Ki67) and intense expression of p53 and glycoprotein P. The patient developed metastasis to the brain four months later and pulmonary and cutaneous metastases shortly thereafter. CONCLUSIONS: Clear cell renal carcinoma can have a rapidly progressive course. Histological studies and determination of adverse immunohistological markers can be useful in these cases.

ATP Binding Cassette Transporter, Subfamily B, Mem↗

PubMed1999

[Verrucous carcinoma of the penis with intense basal expression of Ki 67].

OBJECTIVE: To report a case of verrucous carcinoma of the penis with a long evolution, with special reference to the immunohistochemical study. METHODS: A 64-year-old male consulted for an exophytic lesion in the penis that he had noted 10 years ago. Physical examination showed no regional adenopathy. The diagnosis of benign papillomatous lesion versus carcinoma was considered. The tumor was excised. RESULTS: The histological analysis demonstrated verrucous carcinoma with a very well-differentiated surface and dysplastic basal nests with a tendency to microinvasion. Immunohistochemical studies showed a greater proliferative activity of the Nests (Ki67), but no overexpression of p53 protein. CONCLUSIONS: Verrucous carcinoma may have a long evolution. Immunohistochemical studies of the Ki67 antigen could be useful to detect microinvasion through a better definition of the more proliferative nests.

Carcinoma, Verrucous↗

PubMed1999

[Non-specific granulomatous prostatitis with epithelioid morphology].

OBJECTIVE: To report a case of nospecific granulomatous prostatitis. METHODS: A 57-year-old male presented with urinary symptoms (pollakiuria and dysuria), but no fever. On physical examination, the prostate was enlarged and indurated. Urine cultures were negative and blood PSA was slightly elevated. The patient had no previous history of surgery. RESULTS: The histopathological analysis showed granulomatous prostatitis with prominent epithelioid histiocytes. Abundant calculi were also found. The special techniques were negative for fungi and BAAR. No evidence of neoplasm was found. CONCLUSION: Granulomatous prostatitis can mimick a carcinoma, clinically and even histologically, particularly in those cases with prominent epithelioid histiocytes.

Granuloma↗

PubMed1998

[Pyelocaliceal urothelial carcinoma associated with pelvis lithiasis].

OBJECTIVE: Epithelial neoplasms of the upper collecting system account for less than 5 percent of all urothelial tumors and they are not histologically unlike those of the bladder. We report a case of pelviocaliceal urothelial carcinoma associated with a calculus in the renal pelvis. METHODS: A 75-year-old man who presented with hematuria, fever and flank pain is described. The US and CT findings disclosed a calculus in the left renal pelvis and hydronephrosis nephrectomy was performed. RESULTS: The pathological analysis revealed a pelviocaliceal urothelial carcinoma on an underlying stone and overexpression of the p53 protein. CONCLUSION: Diagnostic imaging techniques may fail to detect tumors of the renal pelvis with a large underlying stone. The overexpression of the p53 protein may be involved in the malignant transformation of the urothelial cells.

Aged↗

PubMed1998

[Calcified spermatocele simulating a neoplasm].

OBJECTIVE: To report a case of a spermatocele mimicking a paratesticular neoplasm. METHODS: A 58-year-old man was admitted to our hospital complaining of paratesticular swelling; a firm mass was detected on physical examination. The ultrasound study showed a paratesticular mass with hyperechoic and hypoechoic areas and calcifications, mimicking a neoplasm. Orchidectomy was performed. RESULTS: The anatomopathological study showed a paratesticular spermatocele with calcification. CONCLUSION: The spermatocele can mimick a paratesticular neoplasm.

Calcinosis↗

PubMed1998

[Fracture of the penis: value of echo-Doppler-color].

OBJECTIVE: A case of traumatic rupture of the corpora cavernosa evaluated by color Doppler ultrasonography is presented. METHODS: A 43-year-old male consulted for a large penile hematoma that had presented 16 hours earlier during sexual intercourse. The patient was evaluated by Doppler ultrasound using a 5 Mhz linear probe. The vascular integrity of the penis was demonstrated by color Doppler ultrasonography of the cavernous arteries and penile veins. RESULTS: Disruption at the base of the right corpus cavernosum associated with a small hematoma appeared as adjacent hypoechoic images. The color Doppler ultrasonic evaluation demonstrated the integrity of the arteries and cavernous veins and no pulsation of the hematoma, indicating conservative management. Four months after the trauma, no changes in erectile function or penile deviation have been observed. CONCLUSIONS: Color Doppler ultrasound is a useful diagnostic imaging technique in the assessment and follow-up of penile trauma.

Adult↗

PubMed1998

[A 56-year-old man with abdominal pain, intermittent claudication and a retroperitoneal mass].

OBJECTIVE: To describe an additional case of idiopathic retroperitoneal fibrosis. METHODS/RESULTS: A 56-year-old man consulted for abdominal pain and previous symptoms of intermittent claudication. A CT scan disclosed a retroperitoneal mass, for which reason the patient was submitted to surgery. Analysis of the biopsy specimen demonstrated retroperitoneal fibrosis. CONCLUSION: Although the clinical diagnosis of this disease is usually based on the CT findings, a histological analysis of the biopsy specimen provides a definitive diagnosis and permits intraperitonization of the ureters, which is the widely accepted treatment, during the same surgical session.

Abdominal Pain↗

PubMed1998

[Exophytic renal angiolipoma versus retroperitoneal liposarcoma].

OBJECTIVE: To report a case of exophytic renal angiomyolipoma mimicking a retroperitoneal liposarcoma on magnetic resonance imaging. METHODS: A large, palpable abdominal mass was incidentally discovered during routine physical examination in a 61-year-old, hypertensive woman. A CT scan disclosed a retroperitoneal mass, 17 cm in diameter, adjacent to the kidney. The MRI findings were diagnostic of liposarcoma. The tumor was resected en bloc. RESULTS: The histopathological findings demonstrated angiomyolipoma. CONCLUSIONS: Exophytic angiomyolipoma can mimic retroperitoneal liposarcoma on MRI.

Angiolipoma↗

PubMed1998

[Bladder carcinosarcoma: chondrosarcoma plus urothelial carcinoma].

OBJECTIVE: To report an additional case of bladder carcinosarcoma. METHODS: An 87-year-old patient was admitted with a one-year history of gross hematuria. Ultrasound evaluation showed a bladder tumor and at cystoscopy a 4 x 3 cm polypoid, broad-based mass was found on the posterior wall of the bladder, surrounded by a multifocal papillary tumor. RESULTS: The tumor was resected transurethrally. Histologically, the tumor was composed of chondrosarcoma and urothelial sarcoma. Immunohistochemically, the sarcomatous elements stained strongly with vimentin and the carcinomatous cells were strongly positive for keratin. CONCLUSIONS: The foregoing findings support the view that these neoplasms are true carcinosarcomas.

Aged↗

PubMed1997

[Giant hypertrophy of the prostate: 2,410 grams of weight and 24 cm in diameter].

OBJECTIVE: To describe what we consider to be the largest prostatic hypertrophy reported in the literature. METHODS: A 57-year-old man consulted for prostatic symptoms during the last few months. He had a large palpable abdominal mass and DRE showed enlargement of the prostate. The intravenous urogram and CT scan were compatible with a retroperitoneal tumor and explorative laparotomy was performed. RESULTS: A large pelvic mass, dependent on the prostate, was found and resected. Pathological analysis of the surgical specimen disclosed a giant adenoma of the prostate, weighing 2410 gm and 24 cm in diameter. Immunohistochemical studies for PSA, vimentin, smooth actin and ki 67 were performed. The tumor showed glandular and stromal hyperplasia. CONCLUSION: Giant prostatic adenoma should be included in the differential diagnosis of retroperitoneal masses. To our knowledge, the case described herein is the largest prostatic hypertrophy reported in the literature.

Humans↗

PubMedDate not supplied

[An occult Leydig-cell tumor in a cryptorchid testis].

OBJECTIVE: A case of Leydig cell tumor in a cryptorchid testis is described. METHODS: A 55-year-old man presented with no specific scrotal symptoms. A cryptorchid testis was discovered on physical examination and the patient was submitted to orchidectomy. RESULTS: A solid, well-circumscribed, round nodule of 0.8 cm in diameter was found in an atrophic testis. The histological examination showed a Leydig cell tumor with crystals of Reinke and immunostaining with vimentin. CONCLUSION: Leydig cell tumor may be related with cryptorchidism.

Cryptorchidism↗

PubMedDate not supplied

[Non-coordinated voiding syndrome: classification and urodynamic characterization].

OBJECTIVES: To determine the urodynamic characteristics of uncoordinated voiding. METHODS: Fifty consecutive patients with a diagnosis of uncoordinated voiding were studied; 82% were females and 18% were males; mean age 11.9 years (range 5 to 34 yrs). All patients had a complete urodynamic study including patient history, neurological evaluation, uroflowmetry, cystometry and detrusor pressure/voiding flow. The perineal electromyographic (EMG) activity was recorded throughout the study using surface electrodes. To rule out neurogenic detrusor-sphincter dyssynergy, periurethral sphincter EMG using concentric nail-electrodes was performed in selected cases (20% of the patients). Based on our urodynamic findings, three subtypes of uncoordinated voiding can be distinguished: Type A: micturition is achieved through detrusor involuntary contraction. Type B: micturition is achieved through detrusor voluntary contraction. Type C: micturition is achieved through abdominal straining. RESULTS/CONCLUSIONS: The most important urodynamic findings in uncoordinated voiding, independently of Q max, were the absence of relaxation and increased perineal EMG activity during uroflowmetry. The detrusor pressure/voiding flow test was essential in the classification of uncoordinated voiding. In our series, 58% of the patients were type A, 28% type B and 14% type C.

Adolescent↗