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Biomedical subjects

J Van Vleet

Publications and source records attributed to J Van Vleet.

6 recordsLinked to original sources
PubMed1999

Computer-assisted evaluation of antibiotic regimen coverage and cost.

Evaluation of the cost-effectiveness of antibiotic regimens has become an essential part of drug selection for pharmacists and physicians. However, these evaluations can be complicated, time-consuming, and, if the data used are not based on local conditions, misleading. The computer program Dare to Compare 98 was developed to provide an analysis of empiric antibiotic regimens. The Infectious Disease Challenge portion of the program lists the commonly identified pathogens in specific infectious diseases. The Antibiogram Susceptibility Reports section generates susceptibility reports based on local antibiogram data or data from institutions nationwide that have similar demographic profiles. Susceptibility information is combined with cost data in the Quality/Cost Index section. Comparison of the quality and cost index values allows the user to determine which regimens provide the optimal microbiologic activity and cost values for treatment of a particular infectious disease based on local data. Thus Dare to Compare 98 can help pharmacists and physicians evaluate antibiotic regimens and their suitability for inclusion in formularies and disease-management algorithms.

Anti-Bacterial Agents↗
PubMed1998

Therapy cost 2000: an electronic tool for evaluating the cost-effectiveness of therapeutic regimens.

Providing quality care to patients at the lowest cost is of primary concern to hospitals, clinics, managed care organizations, integrated health systems, and other health care providers operating in a prospective payment environment. Therapy Cost 2000 can help health care providers and decision-makers in a variety of settings reach the goal of cost-effective, high-quality patient care.

Cost-Benefit Analysis↗
PubMed1977

Ultrastructural alterations in skeletal muscle of ducklings fed selenium-vitamin E-deficient diet.

Newly-hatched ducklings were fed a selenium-vitamin E-deficient diet for 13 to 21 days. Ducklings were killed sequentially and the skeletal muscle alterations were studied by light and electron microscopy. An early alteration in skeletal muscle fibers was lysis of myofibrils, at first focal and later widespread. The sarcoplasm of damaged fibers appeared hyalinized by light microscopy. Degenerated skeletal muscle fibers with extensive lysis of myofibrils also had marked mitochondrial alterations, including swelling, formation of matrical densities, disruption of cristal membranes, and persistence of thick, dense, wavy, disrupted membranes. A sheath of external lamina persisted over degenerated segments of fibers which were invaded by macrophages that phagocytosed and removed the sarcoplasmic debris. Regeneration in damaged fibers was thought to proceed from thin subsarcolemmal satellite cells that survived the degenerative process. These satellite cells apparently developed into myoblasts, which fused to form myotubes that extended through the degenerated segments of fibers. Fibrillogenesis and sarcomerogenesis were apparent in myotubes. These structural alterations are discussed in terms of current knowledge of the combined biochemical role of selenium and vitamin E in maintaining cellular integrity.

Animals↗