PubMed Health⌕ Search

Biomedical subjects

J Van Zile

Publications and source records attributed to J Van Zile.

5 recordsLinked to original sources
PubMed1984

Vasodepressor carotid sinus syncope.

There have been few reports of vasodepressor carotid sinus syncope, as opposed to the cardioinhibitory type, and no definitive treatment has been described. A 58 year old man developed episodes of syncope after surgery and radiotherapy for a laryngeal tumour. The episodes were characterised by hypotension, sharp pain in the right neck, dizziness, and bradycardia. A temporary pacemaker failed to prevent the symptoms, but ephedrine and fludrocortisone produced substantial improvement. Of the four types of treatment used in carotid sinus syncope, irradiation was ruled out because the patient had had irradiation before developing syncope, surgery was inappropriate because of the laryngeal tumour, and pacing failed. Combined drug treatment with a vasoconstrictor and plasma volume expander produced an improvement in symptoms but did not eliminate them.

Carcinoma, Squamous Cell↗
PubMed1981

Platelet aggregation and release of ATP after incubation with soluble immune complexes purified from the serum of diabetic patients.

Human platelets are known to have Fc receptors that are able to recognize soluble immune complexes and to respond to that stimulation by aggregating and releasing soluble factors. In diabetes, enhanced platelet aggregation has been proposed as one of the factors contributing to the development of microangiopathy. Soluble immune complexes isolated from seven diabetic patients were found to enhance ADP-induced platelet aggregation and release of ATP. This enhancement was proven not to be an artifact due to the isolation protocol, by comparison of purified immune complexes with nonspecific protein purified from normal sera by identical or slightly modified isolation protocols. Soluble immune complex appear to be the first well-characterized platelet aggregating factors form the sera of diabetic patients. The natural of the antigen involved in their formation does not appear relevant, since very similar results were obtained whether soluble immune complexes were purified from patients with insulin-anti-insulin complexes in their serum, or from those without such complexed but with positive results in nonspecific screening techniques.

Adenosine Diphosphate↗
PubMed1981

Plasma factors and platelet aggregation in diabetes mellitus.

Plasma fron some diabetic patients, particularly those with advanced retinopathy and nephropathy, will potentiate ADP-induced platelet aggregation. Partial purification of plasma from a diabetic patient with nephropathy has yielded a fraction with this activity. A linea dose response curve relating plasma factor (6.25-50 ng protein) and platelet aggregation or ATP release at 4 minutes after adding ADP has been found. The effect is blocked by exposure of platelets to aspirin, prostaglandin or eicosapentaenoic acid. Soluble immune complexes are found in many diabetics and are known to be platelet-active. We have isolated immune complexes from sera of six diabetics and have shown enhancement of the second phase of platelet aggregation and of ATP release by these immune complexes from platelets sensitized to ADP. We conclude that plasma proteins from diabetics may accentuate ADP-induced platelet aggregation and ATP release, possibly by acting through prostaglandin pathways. Immune complexes appear to be one group of plasma proteins with such platelet active behavior. Further studies are indicated to characterize these plasma factors and to assess their in vivo significance regarding platelet function and vascular disease in diabetes mellitus.

Antigen-Antibody Complex↗