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Biomedical subjects

J Van den Driessche

Publications and source records attributed to J Van den Driessche.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Comparative study of the progestomimetic and contraceptive activity of quingestanol acetate with 5 other progestational molecules].

The progestomimetic, contraceptive activities of quingestanol acetate are compared to those of five molecules (chlormadinone acetate, norgestrel, progesterone, norethisterone acetate, lynestrol). In the opinion of the authors, the therapeutic efficacity of contraceptive pills cannot be judged solely according to the weight of their various ingredients. An appreciation of the value of the various substances is based on a comparison between their physiological activity and their weight. The concept of a mini-dosage pill should therefore be considered, and due consideration paid to the physiological activity of each ingredient. In the experiments described here, quingestanol acetate shows marked statistical differences to the other five molecules.

Animals↗
PubMed1980

[Effect of ascorbic acid during acute iterative anoxia, hypothesis of an anti-oxidizing mechanism of action in comparison with the effect of hydroquinone].

Some of the problems which appear during senescence, are said to be caused by cerebral oxygen deficiency and various experiments have been set up to try to imitate this particular aspect of the ageing process. We have already studied the action of many drugs with regard to acute repeated anoxia. Our work has given us clear evidence of the activity of ascorbic acid, which delays the moment of electroencephalographic silence in rats and decreases the latent period up to the reappearance of electrical activity. In order to pinpoint the mechanism of action, we compared the influence of lysine aceto-salicylate with that of hydroquinone. Very small doses of the latter drug produce a marked effect and lead us to put forward the hypothesis that it may be anti-oxydising. However, although all the drugs which proved effective in these experiments may be grouped together (despite their varying pharmacological profiles) and described as "anabiotic" drugs, it is not possible to revert to a single mechanism of action for the group as a whole.

Animals↗
PubMed1979

Plasmatic renin activity in patients treated with L-dopa and inhibitor of dopa decarboxylase (IDC).

Plasmatic renin activity (PRA) was studied in patients receiving L-dopa, together with a decarboxylase inhibitor, at rest times and after periods of physical exertion. Although we can superimpose the results from unrelated Parkinson's disease patients on those of the control group, the results are inversed in stabilized patients (lowered PRA) and dyskinetic patients (increased PRA). There is a definite correlation between the increase in PRA and intensity of the dyskinesia. Dosage is the only other factor differentiating the two groups of Parkinsonians treated. The figures relative to arterial pressure are studied in the various groups.

Adult↗
PubMed1979

[Influence of a tributyltin oxide oily aerosol on the exploratory behaviour toward the mouse (author's transl)].

Inhalation of an oily aerosol of bis (tributyltin oxide) (TBTO) after single or repeated expositions (1 hour) disturb the exploratory behaviour in the mouse. Weak concentrations (42 and 84 ppm) stimulate exploratory activity while large doses (170 and 340 ppm) significantly decrease it. Modification in brain amine levels may appear but the observed perturbance seems to be more dependent from oily vehicule than TBTO itself.

Aerosols↗
PubMed1978

Cerebral metabolic, hemodynamic and antihypoxic properties of l-eburnamonine.

l-Eburnamonine--16-oxoeburnane--assumes experimental cerebral 'oxygenator' and antihypoxic properties which appear more pronounced than those of vincamine. In anesthetized dogs, l-eburnamonine increases the cerebral oxygen supply and the cerebral oxygen consumption, without cerebral vasodilation; l-eburnamonine improves the cerebral capillary circulation, as observed on the rheoencephalogram. l-Eburnamonine inhibits the effects of hypobaric hypoxia in mice (increase of survival time) and in rats (inhibition of amnesic effects of hypoxia). l-Eburnamonine decreases the electroencephalographic consequences of the acute and iterative asphyxic anoxia in curarized rats and, by means of the protection of the cerebral cortex, inhibits the postischemic increase of thalamic somesthetic evoked potentials in curarized cats. Further studies are necessary to precise the mechanisms involved in these 'cerebral protective' properties of l-eburnamonine.

Acute Disease↗
PubMed1978

[Influence of age on the modifications of cerebral electrogenesis in the curarized rat induced by acute and repeated asphyxic anoxia].

In curarized rats, acute and iterative asphyxic anoxia produced large modifications of the cerebral electrogenesis, whose intensity could be evaluated, during each anoxia, by measurements of three parameters : the resistance to anoxia, the post-asphyxic recuperation and the cerebral electric silence. Comparative trials, carried out on animals of the same stock, showed that the cerebral sensibility towards anoxia was very different according to their age : maximal sensibility in 2 or 28 months old rats, minimal sensibility between 8 to 15 months. These results are discussed in terms of choice of animal material and specially of the age of rats used for study of the cerebral anoxia, as well as for the study of cerebral anti- hypoxic drugs.

Aging↗
PubMed1977

[Effects of a beta-adrenolytic and a diuretic vis-à-vis hyper-reninemia induced by isoprenaline in anesthetized dogs. Value of beta blocking-diuretic interaction].

Intravenous injection of isoproterenol increases plasma renin activity (PRA) in anesthetized dogs. S. 464, a new beta adrenergic blocking agent, injected five minutes before isoproterenol, inhibits plasma renin hyperactivity. On the other hand, teclothiazide, a thiazide diuretic, induces no significant modification of the isoproterenol-induced increase of PRA. The combination of both compounds (five parts of S. 464, one part of diuretic), assumes the same inhibitory effects as S. 464 alone. These results and other experimental data (antihypertensive and diuretic activities) are discussed and explain the interest of such an association as a rational therapy of arterial hypertensive disorders.

Adrenergic beta-Antagonists↗
PubMed1977

[Action of 3-beta adrenolytics on plasma renin activity measured by radioimmunology in genetically hypertensive rats].

Spontaneously hypertensive rats (SHR) have basal levels of plasma renin activity (PRA) lower than the ones observed in normal Sprague Dawley rats. Three beta blocking agents are orally administered to unanesthetized spontaneously hypertensive and normotensive rats. Propranolol and S 464 reduce PRA in spontaneously hypertensive and normotensive control rats. Pindolol do not lower PRA in normotensive rats but increases levels of PRA in spontaneously hypertensive rats. These results are discussed.

Adrenergic beta-Antagonists↗