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Biomedical subjects

J Vance

Publications and source records attributed to J Vance.

30 records · Page 2Linked to original sources
PubMed1991

North Carolina macular dystrophy: exclusion map using RFLPs and microsatellites.

The autosomal dominant macular dystrophies are a confusing group of poorly understood diseases. Linkage studies will greatly aid our classification of these disorders and hopefully provide insight into central retinal function and dysfunction such as occurs in age-related macular degeneration. North Carolina macular dystrophy is one such disease that has been amenable to linkage analysis because of the large pedigree size. Seventy-six polymorphic markers have been tested for linkage and exclusion data are presented.

Chromosome Mapping↗
PubMed1983

Comparative gastric irritation by two buffered acetylsalicylic acid formulations and acetylsalicylic acid. A gastric potential difference analysis.

In a single dose clinical investigation two buffered acetylsalicylic acid formulations (Ascriptin and Ascriptin A/D) were shown to be significantly less irritating to the human gastric mucosa than acetylsalicylic acid, and no more irritating than a pharmacologically inert placebo. The measurements were taken using a minimally invasive method for recording transmural gastric potential difference changes versus time.

Adult↗
PubMed1982

Digital image processing: a path to better pictures.

Digital image processing has been used for over a decade to provide startling improvements in the quality of photographs from deep space, satellites and low light level photography. In the last decade considerable work has gone on in major microscope labs in applying these techniques to electron micrographs. Within the last few years a number of factors have come together which allow large scale image processing techniques to be applied at reasonable costs in microscope labs everywhere. The system described here provides hardware for digitization and storage of multiple images simultaneously and multimode scan generation. System software provides easy scan control, image digitization, automatic prescale adjust on acquisition, grey scale histogram generation, grey scale manipulation, image filtering, smoothing, and random color assignment to grey levels.

Animals↗
PubMed1976

Extraction of digoxin and its metabolites from urine and their separation by Sephadex LH-20 column chromatography.

The efficiency with which serveral solvent systems extract digoxin and its metabolites from urine has been studied and column chromatography using Sephadex LH-20 has been used to separate digoxin and its metabolites. These procedures have been evaluated and used to study the excretion of 3H-digoxin-12alpha and its metabolites in urines collected serially in 7 patients and in bile in one. The percentage of the radioactivity excreted as metabolites in urine and bile was found to reach a peak within the first day and then to gradualy decline to minimal amounts in patients with advanced renal failure as well as those with good renal function. The maximum percentage measured as metabolites in 4 patients with the most advanced renal failure was 10%.

Bile↗