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Biomedical subjects

J Vantelon

Publications and source records attributed to J Vantelon.

At least 19 recordsLinked to original sources
PubMed1983

[Autoimmune thyroid diseases associated with glomerular nephropathy. 3 cases].

The first patient had Hashimoto's thyroiditis and developed membranous glomerulonephritis with subepithelial deposits of IgG, C3, and thyroglobulin; the second patient had Graves' disease and developed, after the second administration of 131 I 2, rapidly progressive glomerulonephritis with epithelial crescents; in the remaining patient, Hashimoto's thyroiditis was diagnosed at the time of renal insufficiency due to crescentic glomerulonephritis. All three patients had circulating antithyroglobulin antibodies, with high titers in patients I and III; in every patient, the search for circulating immune complexes was negative at the time of the renal biopsy. Apart from the classical membranous type, other glomerular lesions may be associated with thyroiditis. The frequent clinical latency of Hashimoto's disease warrants systematically testing for circulating antithyroglobulin antibodies in women presenting with apparently idiopathic glomerulonephritis.

Adult↗
PubMed1981

Structural and ultrastructural peritoneal membrane changes and permeability alterations during continuous ambulatory peritoneal dialysis.

Normal and abnormal structure of the peritoneum is described in biopsies obtained from 15 cadavers and 13 patients on continuous ambulatory peritoneal dialysis (CAPD) at the onset of their treatment and after several months. In a few patients a loss of ultrafiltration due to a higher permeability of the peritoneum for glucose was observed. This hyperpermeability seems to be due to a patchy or total destruction of the mesothelium; it seems also to be dependent upon the thickness of the fibrous band separating capillaries from the peritoneal cavity. The endothelium of capillaries was normal in all the specimens examined.

Cell Membrane Permeability↗
PubMed1980

[Has haemofiltration a specific therapeutic effect? A co-operative study involving 20 patients (author's transl)].

In order to evaluate the effects of haemofiltration (HF) on blood pressure control, hyperparathyroidism and hypertriglyceridaemia, the relevant clinical and biological parameters were compared under haemodialysis (HD) and under haemofiltration using a substitution fluid (SF) acetate. Blood pressure control was achieved with HF in only one of 14 hypertensive patients. In 17 patients, with the same doses of Al (OH)3, plasma phosphate levels were similar under HD (63 mg/l) and HF (67 mg/l). In 3 patients, measurements of plasma parathyroid hormone (PTH) levels in the presence of increasing concentrations of SF calcium showed that a concentration of 90 mg/l was required to obtain a positive calcium balance and a decrease in PTH levels. After 6 months, PTH levels under HD and under HF were comparable. In 20 patients, there were no significant differences between HD and HF in mean plasma concentration values of total lipids, cholesterol and triglycerides. Finally, HF was better tolerated than HD in 58% of the cases and less well tolerated in 8%.

Blood↗
PubMed1977

[Is it possible to treat uremia by hemofiltration? Initial clinical results obtained with a poly-acrylo-nytril membrane].

Following to work of Quellhorst, the authors used an RP6 haemodialyser as an ultrafilter and exchanged 20 litres of plasma ultrafiltrate against 18 to 20 litres of physiological solution during 200 sessions of 4 to 5 hours in 5 patients with uraemia, over a period of 3 to 10 months. The technique is simple and tolerance excellent. The possibility of a new approach to the treatment of uraemia without dialysate makes a large clinical trial worthwhile.

Acrylonitrile↗
PubMed1975

[Periodic hemodialysis. Application of new theories and technics to shortening the dialysis sessions].

Many attempts are now being made to reduce the time of dialysis in chronic uremia. The method developed by Funck-Brentano, Man and Sausse, which includes the use of a highly permeable membrane and precise control of ultrafiltration, is theoretically logical. It was easily applied to 22 unselected patients, treated nine hours weekly for two to eight months. Of course, the follow-up is insufficient. The dosage of products permitting the digestive elimination of phosphorus and potassium must be revised, but the improvement in physical and psychological tolerance of treatment is such that a return to long duration dialysis can no longer be considered possible.

Humans↗