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J Velly

Publications and source records attributed to J Velly.

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[Pharmacokinetics of S 3341. Analysis by inhibition of the specific binding of 3H-clonidine].

1. The radioreceptor assay for S 3341, an alpha 2-adrenergic agonist, is based on the ability of the S 3341 to compete with the specific binding of [3H] clonidine to alpha-receptors of rat cerebral cortex membranes. The technique described was used for S 3341 plasma determination. 2. S 3341 levels in plasma and blood pressure were measured in hypertensive subjects 1, 3, 5, 8, 12, 24 and 48 hours after ingestion of the drug. 3. The s 3341 plasma level rose to a maximum between the first and the third hours after ingestion and then declined, with a mean half-life of 14 hours. There were substantial inter-individual variations, ranging from 3 to 24 hours. 4. The fall in blood pressure mirrored the increase in the s 3341 plasma level during the three hours following the ingestion of the drug.

Adrenergic alpha-Agonists↗