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J Verrier-Jones

Publications and source records attributed to J Verrier-Jones.

8 recordsLinked to original sources
PubMed1977

Relationship between anti-DNA antibodies complement consumption and circulating immune complexes in systemic lupus erythematosus.

Eighty-nine sera from nineteen patients with systemic lupus erythematosus (SLE) have been studied to determine the relationship between levels of DNA-binding activity, complement consumption and evidence of circulating immune complexes. There was a good correlation between the height of DNA binding, a rising C3i and a reciprocal fall in C3, C4 and CH50 levels. These latter measurements provided useful supplemental information when studied serially. There was a good correlation between the results of the various methods used for the detection of circulating immune complexes, and these were found in almost half the sera with DNA binding over 70%. It is concluded that serial studied of DNA binding, complement levels, and direct tests for immune complexes, may provide valuable information in the management of patients with SLE.

Antibodies, Antinuclear↗
PubMed1976

Penicillamine nephropathy in rheumatoid arthritis. A clinical, pathological and immunological study.

Fourteen patients who developed persistent proteinuria while on penicillamine for rheumatoid arthritis, were collected over a period of one year. Eleven patients had a frank nephrotic syndrome and three had a lesser degree of proteinuria but no oedema. The patients had received penicillamine (mean daily dose 1015 mg) for less than one year (mean 7-5 months) when the nephropathy was detected. Clinical investigations have been correlated with renal biopsy material. Light microscopy detected no abnormalities except for minimal hypercellularity in a few patients. In markde contrast, the electron-microscope revealed numerous electron-dense deposits (EED's) in the outer layer of the basement membrane. Immunofluorescence showed the presence of IgG and complement in the basement membrane, the intensity of which correlated with the number of EED's. The pathological picture was essentially the same in those patients with the nephrotic syndrome and those with proteinuria. In this series, we found no evidence that penicillamine induced renal damage by any other mechanism except immune complex deposition. Serological tests revealed little evidence for complement activation or consumption and platelet aggregation was the only positive direct test for circulating immune complexes. Renal biopsies were performed at differing intervals after the cessation of penicillamine therapy, which allowed assessment of the natural history of the pathological lesion and revealed a striking persistence of EDD's in some patients. Two patients showed an almost identical picture initially and at re-biopsy one year later. Persistent proteinuria was also a feature of the group as a whole. The pathological picture has similarities with that of idiopathic membranous glomerulopathy. This study suggests that the use of penicillamine in rheumatoid arthritis may induce persistent renal damage.

Adult↗
PubMed1974

A set of surface proteins common to the circulating human platelet and lymphocyte.

The surface proteins of the circulating human platelet and lymphocyte were labelled by using the lactoperoxidase iodination method. Polyacrylamide-gel electrophoresis showed that four corresponding labelled proteins are found on the surface of each cell type. The most intensely labelled protein contains little or no carbohydrate, but the remaining labelled proteins are all glycoproteins. The major labelled band from each cell was isolated and comparative peptide ;maps' showed that the two proteins are closely similar. The surface proteins of the lymphocyte and platelet are distinct from those on the erythrocyte, the remaining major type of circulating cell.

Blood Platelets↗