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Biomedical subjects

J Vesper

Publications and source records attributed to J Vesper.

At least 37 records · Page 2Linked to original sources
PubMed1981

Effects of truncal vagotomy and antrectomy on bombesin-stimulated pancreatic secretion, release of gastrin, and pancreatic polypeptide in the anesthetized dog.

The short-term effects of truncal vagotomy and antrectomy on bombesin-stimulated pancreatic secretion and release of gastrin and pancreatic polypeptide (PP) were studied in 18 anesthetized dogs. Together with an intravenous infusion of secretin (250 ng/kg/hr) bombesin (500 ng/kg/hr) was given before and after truncal vagotomy, antrectomy, and sham operation (N = 6 dogs per group). Peak incremental pancreatic protein output in response to bombesin was about 2-3 times higher before than after the different surgical procedures (tachyphylaxis). Neither truncal vagotomy nor antrectomy significantly altered the pancreatic protein response to bombesin when compared with sham operation. Bombesin produced a mean 1-hr increase over basal of 196 pM for gastrin, which was abolished by antrectomy but not appreciably affected by truncal vagotomy and sham operation. The mean 1-hr increment (207 pM) for PP in response to bombesin was not changed by truncal vagotomy, antrectomy, and sham operation. This study shows in the anesthetized dog that exogenous bombesin stimulates release of PP as well as gastrin; that the release of gastrin by bombesin is not vagally dependent; that neither truncal vagotomy nor antrectomy alter the release of PP by bombesin; and that the action of bombesin on pancreatic protein secretion does not depend on release of gastrin or on intact vagal nerves.

Animals↗
PubMed1981

[The treatment of epilepsies with Convulsofin].

The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to carry out a monotherapy to a remarkable extent. The favourable effect of the preparation in photosensitivity could be confirmed. Also in generalised secondary epilepsy and in fits of partial epilepsy. Convulsofin is partly effective, so that it can recommended as a co-medication in the treatment of therapy-resistant forms of these epilepsies which are difficult to treat. Decrease in thrombocytes, transient increase in serum transaminases, gastrointestinal disorders, loss of hair and undesired increases in body-weight were the more frequently occurring side-effects.

Adolescent↗
PubMed1979

[The effect of atropine on the pancreas].

The literature relating to the effect of atropine on exocrine pancreatic secretion in man and animals is critically reviewed. In most species basal secretion of volume, bicarbonate, and enzyme secretion are reduced by atropine, thus indicating some neural control of basal pancreatic secretion. The literature is replete with conflicting findings on the effect of atropine on pancreatic response to exogenous hormones. In well controlled studies atropine had no effect on the action of cholecystokinin-pancreozymin (CCK) or caerulein on the pancreas. Atropine either moderately depressed or did not alter the volume and bicarbonate response to secretin but constantly reduced enzyme secretion. With respect to pancreatic response to a meal, and to intestinal instillation of aminoacids, fat or HCL, all studies agree that pancreatic secretion is depressed by atropine. The recent finding that atropine did not alter the response of a transplanted denervated pancreas to intestinal stimulants suggests that atropine acts on the pancreas by interrupting an enteropancreatic vago-vagal reflex and not by blocking the action of hormones on the pancreas or by interfering with cholinergic facilitation of gastrointestinal hormone release.

Anesthesia↗
PubMed1979

[Personality structure and child-rearing behavior of parents of children with psychologically defective development].

The personality structure and educational methods of parents exert considerable influence on the emergence of psychic defects in children. Tests have been conducted with a group where cerebro-organic damage but no psychic defects occurred, another group of children showing psychic defects and previous cerebro-organic injury, and a third group with psychic defects. In the last two groups there was a marked recurrence of traits from the personality structure of the parents, and a larger number of misguided attitudes and educational activities occurred.

Brain Damage, Chronic↗
PubMed1979

[Treatment of epilepsy with clonazepam (Antelepsin)].

Clonazepam (Antelepsin) was tested on 179 patients in 8 institutions during a period of 180 days. 169 patients had been unsuccessfully treated with the usual standard medication and were additionally given Antelepsin. Typical absences and attacks of the West and Lennox syndromes yielded best to treatment with the drug, with favorable effects also being produced in cases of partial or focal epilepsy. The most important side-effect was tiredness, other collateral effects being balance disorders, sensations of dizziness, and musuclar weakness. The frequency of side-effects decreased in the course of therapy. In the electroencephalogram there was observed a significant increase in beta waves and a significant decrease in 3 Hz spike and wave complexes.

Benzodiazepinones↗
PubMed1979

[Cerebromeningeal fibroxanthoma. A case report].

This is a report on an almost seven-year-old girl with a histologically evident fibroxanthoma of the leptomeninx and dura mater cerebri. To the authors' knowledge, this is the fifth case of an intracranial fibroxanthoma reported in the literature. Histologically, the tumor consists of close-lying pleomorphic cells and giant multinuclear cells with vacuolate or homogeneous eosinophilic cytoplasm and fusiform cells occasionally arranged in meningeoma-like whorls. The experience gathered thus far shows that, so far as intracranial fibroxanthomata are concerned, predictions or conclusions regarding the course of disease and the probability of recovery should be made with reservation only.

Age Factors↗
PubMed1977

Peridural lipomatosis.

Fifteen cases of peridural lipomatosis are presented. All patients were treated surgically in the years 1965 to 1974 and reexamined in 1975. In 5 cases of condition improved, in 4 cases it was unchanged and in 6 patients it deteriorated. It is emphasized that the question of surgical therapy must be decided individually.

Child↗
PubMed1976

[Differential diagnosis of cerebral convulsive seizures in the tetanic syndrome].

An analysis of the types of attacks occurring in tetanus patients shows that epileptic attacks are a relatively frequent occurrence in such patients. In patients under anti-epileptic therapy it is readily possible for the clinical picture to be concealed, and this may then result in irreversible damage due to the disturbance of metabolism remaining uninfluenced. It is recommended that the treatment of patients with cerebral attacks should include measures aimed at preventing the occurrence in them of convulsions resulting from the particular metabolic situation in the case of tetanus. What is also pointed out by the authors in their present paper is that tetanus patients treated with anticonvulsives and particularly disposed sufferers from epilepsy may show a deterioration of the metabolic situation and a loss of stability of the vitamin D metabolism, respectively. Accordingly, it is advisable that regular clinical and paraclinical checks be made in the case of the two syndromes referred to above.

Adolescent↗
PubMed1976

[Adrenoleukodystrophy. Clinical-pathologic case history and literature review].

This article presents the clinical and pathological history of a 10-year-old boy with adrenoleukodystrophy as well as a tabular survey of 17 additional cases of which the necropsy records were published in the literature. So far as the case of adrenoleukodystrophy directly observed by the authors themselves is concerned, commencement of the disease was in the seventh year of life, with symptoms of Addison's disease and diffuse inflammatory cerebral sclerosis being observed at about the same time. The cerebral disease manifested itself as a progressive pseudobulbar and pyramidal tract symptomatology and as a progressive cerebral psychosyndrome reminiscent of an endocrinal psychosyndrome. Morphologically, the adrenoleukodystrophy was characterized by severe dystrophy of the cortex of the suprarenal gland and the brain are considered the points of action of a still unknown noxa.e suprarenal gland as well as by extensive sudanophilic processes of decomposition in the cerebromedullary substance, putamen, pallidum, and thalamus. Striated cells and cytoplasmic filamentous inclusions observed in the brain and suprarenal glands in a number of cases reported in the literature were not found by the present authors. The cortex of th

Addison Disease↗