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J Vial

Publications and source records attributed to J Vial.

22 records · Page 2Linked to original sources
PubMed1986

Effect of vasoactive peptides on prostacyclin synthesis in man.

Bradykinin, angiotensin II, arginine vasopressin (AVP) or des-amino-D-arginine vasopressin (DDAVP) were administered by intravenous infusion to 10 healthy men. The concentration of 6-oxo-prostaglandin F1 alpha (6-oxo-PGF1 alpha), the stable hydrolysis product of prostacyclin (PGI2), was measured in plasma using gas chromatography/negative ion chemical ionisation mass spectrometry. Dose-related increases in plasma concentrations of 6-oxo-PGF1 alpha occurred during administration of bradykinin (100-3200 ng kg-1 min-1). The concentrations of 6-oxo-PGF1 alpha rose from baseline values in the range less than 1.0-4.9 pg ml-1 to 24.9-47.6 pg ml-1 at maximum tolerated infusion rates. There were no changes in the concentrations of 6-oxo-PGF1 alpha during administration of angiotensin II, AVP or DDAVP at infusion rates which caused haemodynamic changes.

6-Ketoprostaglandin F1 alpha↗
PubMed1975

Scanning microscopy of dissociated tissue cells.

A method is described for studying by scanning electron microscopy (SEM) all the surfaces of fully differentiated cells from intact tissues. Thus, cell faces normally hidden from view are exposed and made available for SEM examination. This is achieved by fixing the tissue in OSO4 and then soaking it in a 1% solution (in water) of boric acid. After different periods of time, varied according to particular tissue, slight mechanical pressure will cause the fixed tissue to dissociate into its component cells. These are then made to adhere to a substrate and are taken through critical point drying, etc., for examination. Observations are reported on the topography of whole hepatocytes, adsorptive cells of the intestinal epithelium, proximal tubule cells of the rat kidney, mammary tumor cells of the mouse, and rat sarcoma cells. Several other tissues are reported to dissociate when similarly treated, but for each the procedure must be slightly modified.

Animals↗