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Biomedical subjects

J W Ager

Publications and source records attributed to J W Ager.

50 records · Page 3Linked to original sources
PubMed1985

Variation of semen measures within normal men.

Variation in semen measures was assessed bimonthly in 15 healthy men over a 6-month period. Average within-subject coefficients of variation for sperm count, morphologic features, motility, and semen volume demonstrate considerable variation. Each day of abstinence increased the volume by an increment of 0.62 ml, the count by 17.6 X 10(6)/ml, and motility by 1.2%. Sperm count and semen volume correlated positively within subjects. Intraclass and serial correlations of semen measures provided an empirical clinical guide to the number and spacing of specimens. Three specimens spaced no more than 2 weeks apart established a reliable semen profile. Findings can be applied to basic research and clinical practice.

Adult↗
PubMed1977

Social work attitudes toward birth control for teenagers.

The current high level of teenage sexual activity has important consequences for the psychological and social well-being of both individuals and the community. Because social workers often have professional contact with teenagers who are in need of contraceptive services, a nationwide survey was conducted to ascertain the attitudes of social work faculty and students toward birth control for teenagers. Both students and faculty were found to have positive attitudes. They are willing to provide service in this area within the bounds suggested by a realistic assessment of their preparation for this field of activity.

Adolescent↗
PubMedDate not supplied

Neonatal outcome following methadone exposure in utero.

To examine the relationship between maternal methadone exposure and neonatal head circumference and abstinence syndrome, we examined the records of 172 opiate-addicted gravidas enrolled in a methadone maintenance program in an urban hospital over a 2-year period. Higher doses of methadone in the third trimester were associated with increased head circumference reflecting both increased gestational duration and improved overall growth. Neonatal withdrawal was positively correlated with gestational age at delivery and race, with nonblack infants exhibiting higher neonatal abstinence scores than blacks following adjustment for maternal dose and gestational age at delivery. Selection of optimal methadone dosage is a complex problem in which the favorable neurobehavioral outcome associated with increased growth and gestational age must be weighed against the risks associated with more severe neonatal withdrawal. Our findings of improved overall fetal growth and gestational duration associated with higher methadone doses suggest that more liberal methadone dosing in pregnancy may improve long-term neonatal outcome.

Black or African American↗
PubMedDate not supplied

Stability of basic semen measures and abnormal morphology within individuals.

Semen from 15 healthy volunteers was assessed for basic semen measures every 2 weeks over a 6-month period to determine the relative stability of these factors. The parameters were: sperm count, semen volume, sperm motility, and normal morphology, along with the type of abnormal morphologic forms. Basic semen measures were generally more stable than the morphologic forms. Using three samples, seven semen factors (sperm count, normal morphology, semen volume, sperm motility, microcephaly, tapering and round tail) were found to be stable and contributed to the identification of the fifteen individuals with a classification accuracy of 75.0%. While individuals do have characteristic patterns of spermatogenesis, the biologic basis for these findings is as yet undetermined.

Adult↗
PubMedDate not supplied

Maternal recall of alcohol, cocaine, and marijuana use during pregnancy.

Alcohol, cocaine, and marijuana use during pregnancy was reported antenatally and at 13 months postpartum by 361 black inner city mothers. The two reports were moderately related for all three substances, but levels reported retrospectively were substantially higher. MAST scores did not differ for the two interviews. Most of the correlations of the antenatal and retrospective reports with maternal and infant characteristics were similar in magnitude; those that differed were somewhat stronger for the antenatal measures. Although the retrospective reports may provide a better indication of mean levels of fetal exposure, they may be less precise in rank ordering among individuals for purposes of correlational analysis. Women with higher MAST scores were particularly prone to report higher levels of both alcohol and cocaine when interviewed retrospectively, and more severely depressed mothers were more likely to report higher levels retrospectively for all three substances. These data suggest that women reporting more than 1.3 drinks/week antenatally (AA/day greater than 0.1) may actually be drinking at levels at risk for alcohol-related birth defects.

Adolescent↗
PubMedDate not supplied

Nonlinear components of age-related change in sleep initiation.

BACKGROUND: Although primary studies suggest that ability to initiate sleep declines as people age, no systematic literature review has addressed the age(s) at which adults experience the greatest change in their ability to initiate sleep. OBJECTIVE: To explore whether there are any points in time across the adult life span when the rate of change in ability to initiate sleep increases or decreases. METHODS: Mathematical modeling was used to generate data points from information about central tendency, variance, and correlations between age and time to sleep onset provided by seven research reports. The reports represent 258 subjects ages 17 to 91 years. Smoothing splines were used to identify inflection points suggestive of major changes in sleep initiation across the life span. RESULTS: Two mathematical models were generated. One model suggested that inflection points may exist around ages 30 and 50 years, respectively. With this model, the amount of time until sleep onset increased until the age of 30 years, but was unchanged from ages 30 to 50 years. Ability to initiate sleep appeared to decline steadily after the age of 50 years. The second model, with a p value of 0.05, lacked adequate power to identify a significant nonlinear trend. CONCLUSIONS: Decline in ability to initiate sleep may not occur at a steady rate over the adult life span. Further research is needed to pinpoint thresholds of change and possible gender differences in thresholds.

Adolescent↗
PubMedDate not supplied

Deep-ultraviolet Raman spectroscopy study of the effect of aging on human cortical bone.

The age-related deterioration in bone quality and consequent increase in fracture incidence is an obvious health concern that is becoming increasingly significant as the population ages. Raman spectroscopy with deep-ultraviolet excitation (244 nm) is used to measure vibrational spectra from human cortical bone obtained from donors over a wide age range (34-99 years). The UV Raman technique avoids the fluorescence background usually found with visible and near-infrared excitation and, due to resonance Raman effects, is particularly sensitive to the organic component of bone. Spectral changes in the amide I band at 1640 cm(-1) are found to correlate with both donor age and with previously reported fracture toughness data obtained from the same specimens. These results are discussed in the context of possible changes in collagen cross-linking chemistry as a function of age, and are deemed important to further our understanding of the changes in the organic component of the bone matrix with aging.

Adult↗
PubMedDate not supplied

Effect of stress on semen quality in semen donors.

Fifty-three donors with good semen quality were studied monthly for sperm count and motility over 9 to 22 months. Medical students (n = 31) in freshman and sophomore years subjected to the stress of twice-yearly examinations were compared with nonstudents (n = 22) not exposed to common stressful periods. Sperm count and quality (count X motility) for the student group were significantly elevated during examination months versus nonexamination months. Controls demonstrated no differences over these months. Differences between individuals, donor selection factors, and the effects of variable degrees of stress on sperm transport may have contributed to this finding.

Humans↗