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J W Broviac

Publications and source records attributed to J W Broviac.

6 recordsLinked to original sources
PubMed1976

The role of Intralipid in prolonged parenteral nutrition. I. As a caloric substitute for glucose.

Three stable patients were studied in order to assess the role of intravenous fat solutions (Intralipid) in long-term home parental nutrition. The standard source of nonprotein calories (NPC) in these patients was 60% glucose. Replacing 40% of NPC by Intralipid was effective in maintaining nitrogen balance and allowed total infusion time to be reduced from 12 hr to 8 hr. The serum triglyceride level was significantly elevated when glucose was used as the sole source of NPC, whereas serum cholesterol was significantly elevated when 40% of NPC were supplied by Intralipid.

Catheterization↗
PubMed1975

Essential fatty acid deficiency in human adults during total parenteral nutrition.

Three patients undergoing prolonged total parenteral nutrition at home developed skin lesions, characterized by dryness and scaly appearance, initially confined to the folds but becoming subsequently generalized. Fatty acid measurements in plasma of these patients showed a markedly abnormal lipid pattern: accumulation of 5,8,11-eicosatrienoic acid (20:3omega9) and a high 20:3omega9-to-20:4omega6 ratio. When parenteral fat (Intralipid) was administered, 500 ml/day, serial measurements of fatty acids showed a progressive normalization of the abnormal pattern and a dramatic improvement in the skin lesions. It appears that the daily requirement for linoleic acid in the adult, particularly during the period of rapid anabolism, has not been clearly established. Because more and more patients are becoming partly or totally dependent on parenteral nutrition for prolonged periods of time, the availability of parenteral fat preparations is urgently needed.

Adolescent↗
PubMed1972

Hyperosmolar coma.

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Blood Glucose↗