PubMed Health⌕ Search

Biomedical subjects

J W Coates

Publications and source records attributed to J W Coates.

8 recordsLinked to original sources
PubMed1988

A survey of malformed aborted bovine fetuses, stillbirths and nonviable neonates for abnormal karyotypes.

Postmortem examinations were performed on 30 morphologically abnormal aborted bovine fetuses, stillbirths and nonviable neonates. Fibroblasts from the pericardium were cultured for chromosome analysis. Karyotypes were successfully completed on 18 animals, of which three were trisomic, one was mosaic monosomic and one was chimeric. All aneuploid calves had multisystemic anomalies. Using chromosomal banding techniques, the abnormal karyotypes were determined to be: 61,XY,+27; 61,XX,+21; 61,XY,+?; 59,XY,-?/60,XY; and 60,XX/60,XY. Bacterial contamination or nonviability of tissues prevented the growth of fibroblasts in culture and cytogenetic analysis of the other 12 animals. It was estimated that 2.0% of all late gestation abortuses and stillbirths may have chromosomal abnormalities characterized by aneuploidy. The findings of this study suggest chromosomal abnormalities characterized by aneuploidy are a significant cause of multisystemic anomalies in aborted bovine fetuses and nonviable neonates.

Abortion, Veterinary↗
PubMed1987

Multiple defects in an aborted bovine foetus associated with chromosomal trisomy.

An aborted full-term bovine foetus bad multisystemic anomalies that included a heart defect, cleft palate, pulmonary hypoplasia and kyphoscoliosis. Karyotyping using pericardial sac fibroblast cells indicated that the foetal cells were trisomic. Trypsin-banding procedures and Giemsa staining revealed that the extra chromosome was presumptively Chromosome 27. This is the first report of chromosomal trisomy 27 in an abnormal bovine foetus, and highlights the significance of chromosomal aberrations as a cause of multi-systemic foetal anomalies.

Journal Article↗