Biomedical subjects

J W Gamel

Publications and source records attributed to J W Gamel.

74 records · Page 5Linked to original sources

PubMedDate not supplied

Evaluation of the tourniquet test as a predictor of diabetic retinopathy.

Medical practitioners often have difficulty in assessing the presence or severity of diabetic retinopathy. The tourniquet test is a method of assessing diabetic capillary fragility that has been felt to reliably correlate with background and proliferative diabetic retinopathy. We studied 100 consecutive diabetic patients and 50 age-matched controls in a masked fashion, using fundus photographs and fluorescein angiography to correlate the amount of capillary fragility with the presence and severity of background and proliferative diabetic retinopathy. Although the severity of diabetic capillary fragility did correlate with the presence and severity of diabetic retinopathy (p less than 0.001), this test was not as good an indicator of diabetic retinopathy as were other risk factors such as duration of diabetes (p much less than 0.001). The tourniquet test is unreliable in predicting the presence or severity of diabetic retinopathy because of its high false negative response rate.

Age Factors↗

PubMedDate not supplied

Accuracy of clinical estimates of tumor dimensions. A clinical-pathologic correlation study of posterior uveal melanomas.

The authors reviewed the clinical records of 50 patients who underwent enucleation for posterior uveal malignant melanoma to determine the correlation between clinical estimates of tumor size made prior to enucleation and pathologic measurements made during gross examination. Linear regression of the pathologic measurements of several tumor dimensions on the corresponding clinical estimates documented correlation coefficients ranging from 0.81 for minimal basal diameter to 0.92 for tumor thickness. Although these values suggest a high level of linear correlation, wide confidence limits indicate a significant level of random variation in the data points. Further, nonzero intercepts and nonunity slopes of the linear regression lines indicate a systematic variation between clinical estimates and gross pathologic measurements of tumor size.

Humans↗