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Biomedical subjects

J W Gard

Publications and source records attributed to J W Gard.

3 recordsLinked to original sources

Fatal overdose of amphotericin B in two preterm infants.

Two premature infants exhibited an acute cardiorespiratory collapse shortly after receiving a 50-fold overdose of amphotericin B (AmB). Despite aggressive intervention both infants died. Serum AmB levels were double the normal therapeutic range. We speculate that two less well-recognized toxic complications of AmB involving the cardiac and respiratory systems may have contributed to the fatal outcome.

Adolescent↗

Employment-related administrative roentgenograms: characteristics of policy formulation and current practice.

A significant proportion of diagnostic medical procedures are used in response to public or private policy rather than in response to an individual patient-physician interaction. We have studied the system whereby such policies are developed and implemented in the case of employment-related chest and lumbar spine roentgenograms, which were found to account for about 11% of the total use of diagnostic radiographs in the state of Michigan. We observed that factors influencing formulation of policy are diverse and largely nonmedical, organizational policies developed in similar environments are often very dissimilar and are highly subject to external influence, and perceptions of policy success and examination utility are typically subjective and uncertain. It is concluded that considerable opportunity exists to enhance the efficacy of such radiographic examinations through leverage provided by their policy-driven nature.

Humans↗