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Biomedical subjects

J W Gerrard

Publications and source records attributed to J W Gerrard.

At least 55 records · Page 3Linked to original sources
PubMed1977

Immunoglobulin levels in white and metis communities in Saskatchewan.

Serum-immunoglobulin levels (IgG, IgM, IgA, IgD, IgE) have been studied in white and metis (Cree Indian) communities in Saskatchewan. The levels of IgG, IgA, IgD and IgE were higher in the metis than in the whites. Both IgG and IgM were higher in females than in males. IgG and IgA levels rose progressively with age. IgM levels rose rapidly during the first year to almost adult levels, and then fell gradually after the age of 30. IgE levels also rose rapidly during the first 3 years of life, were higher on average in children than in adults, and fell to adult levels at puberty. Low levels of IgA were associated with high levels of IgG; they were not associated with either high levels of IgE or an increase in the prevalence of asthma.

Adolescent↗
PubMed1977

Serum IgE levels in forty families studied for two or three years.

Serum IgE levels have been measured over two to three years in 210 individuals. In one-fifth IgE levels remained remarkably constant, in one-quarter they rose and in half they fell. A rise was usually associated with the development of fresh atopic disease, exacerbation of established disease or dependence on symptomatic treatment. A fall was associated with a diminution in the severity of symptoms occurring spontaneously as a result of good environmental control or of appropriate immunotherapy. Sequential IgE levels provide confirmatory evidence of the success of either environmental control or of immunotherapy.

Family↗
PubMed1976

The familial incidence of allergic disease.

The familial incidence of asthma, hay fever, recurrent rhinitis, recurrent bronchitis, eczema and urticaria was studied in 176 normal families. When these diseases, with the exception of urticaria, were present in a parent there was an increase in prevalence of the same disease in the child. This suggests that there is a heritable component in the end organ most easily sensitized in the allergic response.

Adolescent↗
PubMed1976

Serum IgE levels in white and metis communities in Saskatchewan.

Serum IgE levels and the prevalence of certain atopic diseases have been studied in 819 individuals in 176 white families living in central Saskatchewan and in 275 individuals in 58 Metis families living in northern Saskatchewan. The geometric mean serum IgE level in the white community (81.3) u/ml) was lower than that in the Metis community (275.4 u/ml). The prevalence of asthma, eczema and urticaria was greater in the white than in the Metis community and contrasted with the increased prevalence of helminth infestation as well as of other untreated viral and bacterial diseases in the Metis community. It is suggested that atopic disease is the price paid by some members of the white community for their relative freedom from diseases due to viruses, bacteria and helminths.

Adolescent↗
PubMed1974

Athyreotic cretinism associated with thymic hypoplasia and amyloidosis of lymphoid tissue.

A child presenting at 5 months of age with Hemophilus influenzae meningitis was also found to be severely hypothyroid. The child died two years later from the complications of measles pneumonia. At autopsy, no thyroid tissue was found and the thymus was hypoplastic. Most of the lymphoid tissues were infiltrated by amyloid.It is possible that there was a combined developmental defect involving thyroid and thymus. The alternatives are that the association occurred purely by chance or that the severe hypothyroid state led to thymic insufficiency.

Amyloidosis↗
PubMed1972

Recurrent urinary infections in girls: relation to enuresis.

Maximum bladder capacities (MBC) have been studied in 89 girls receiving treatment for urinary infections at a time when the infection had been controlled. Fifty-six of the girls had been enuretic when first seen, 40 remained enuretic even when the infection had been cured. The MBC's of the enuretic children were significantly smaller than those who were not or had not been enuretic. The enuresis and small bladder capacities were therefore not usually due to the urinary infection. It is concluded that in girls either enuresis predisposes towards the development of urinary infections, or that a common underlying pathology predisposes to both entities.

Adolescent↗
PubMed1972

Enuresis: familial incidence and relationship to allergic disorders.

An analysis is made of the incidence of allergic diseases in 105 enuretic boys and girls, in their parents and siblings, and in matched controls. There is an increased incidence of hay fever, urticaria and food and drug allergies in enuretic boys. There is an increased incidence of enuresis in the parents of enuretic children. Enuretic children and their fathers are significantly more prone to develop urinary infections than are controls; there is also an increased incidence in urinary infections in their mothers, but numbers are insufficient to indicate that this is significant.

Child↗