Vesiculobullous cutaneous lymphatic reflux.
Although lymphedema is a fairly common condition, cutaneous vesicles and bullae due to reflux of lymphatic fluid are rare. We describe a patient with adenocarcinoma of the cervix treated by radiation in whom acute secondary lymphedema with overlying clear vesicles and bullae developed. Histopathologic examination revealed a subepidermal vesicle communicating directly with a dermal lymphatic vessel. Vesicles occur only in lymphedema of acute onset. Vesiculobullous cutaneous lymphatic reflux should be recognized as a rare complication of lymphedema and included in the differential diagnosis of cutaneous blistering disease.
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