Biomedical subjects

J W Hall

Publications and source records attributed to J W Hall.

At least 19 recordsLinked to original sources

PubMed1992

Cryobiological preservation of Drosophila embryos.

The inability to cryobiologically preserve the fruit fly Drosophila melanogaster has required that fly stocks be maintained by frequent transfer of adults. This method is costly in terms of time and can lead to loss of stocks. Traditional slow freezing methods do not succeed because the embryos are highly sensitive to chilling. With the procedures described here, 68 percent of precisely staged 15-hour Oregon R (wild-type) embryos hatch after vitrification at -205 degrees C, and 40 percent of the resulting larvae develop into normal adult flies. These embryos are among the most complex organisms successfully preserved by cryobiology.

Animals↗

PubMed1992

Masking release for gap detection.

In random noise, masking is influenced almost entirely by noise components in a narrow band around the signal frequency. However, when the noise is not random, but has a modulation pattern which is coherent across frequency, noise components relatively remote from the signal frequency can actually produce a release from masking. This masking release has been called comodulation masking release (CMR). The present research investigated whether a similar release from masking occurs in the analysis of a suprathreshold signal. Specifically, the ability to detect the presence of a temporal gap was investigated in conditions which do and do not result in CMR for detection threshold. Similar conditions were investigated for the masking level difference (a binaural masking release phenomenon). The results indicated that suprathreshold masking release for gap detection occurred for both the masking-level difference (MLD) and for CMR. However, masking release for gap detection was generally smaller than that obtained for detection threshold. The largest gap detection masking release effects obtained corresponded to relatively low levels of stimulation, where gap detection was relatively poor.

Acoustic Stimulation↗

PubMed1992

Comodulation masking release for speech stimuli.

This study sought to determine whether speech recognition in a modulating noise background can be facilitated by a process attributable to comodulation masking release (CMR). Experiment 1 examined the masked identification of six filtered vowels as a function of the number of comodulated noisebands present. A benefit of increased number was observed, consistent with an interpretation in terms of CMR, although it could not be certain that the basis of the discrimination was word recognition in the semantic sense. Experiment 2 made use of a forced-choice rhyming test in which the response foils differed only in a single filtered consonant; again, the measure of interest was performance as a function of the number of comodulated noisebands present. No evidence for a suprathreshold CMR was observed. Experiment 3 made use of open-set sentence material and employed a different paradigm, which allowed a measure of CMR in terms of the difference between thresholds in correlated and uncorrelated noise to be determined. While a CMR for speech detection was observed, no CMR for speech recognition was found. It was concluded that CMR is most evident in masked detection tasks and that diminishing returns are encountered as the signal-to-masker ratio is raised.

Attention↗

PubMed1992

The detection of temporal gaps as a function of frequency region and absolute noise bandwidth.

Temporal gap detection was measured as a function of absolute signal bandwidth at a low-, a mid-, and a high-frequency region in six listeners with normal hearing sensitivity. Gap detection threshold decreased monotonically with increasing stimulus bandwidth at each of the three frequency regions. Given conditions of equivalent absolute bandwidth, gap detection thresholds were not significantly different for upper cutoff frequencies ranging from 600 to 4400 Hz. A second experiment investigated gap detection thresholds at two pressure-spectrum levels, conditions typically resulting in substantially different estimates of frequency selectivity. Estimates of frequency selectivity were collected at the two levels using a notched-noise masker technique. The gap threshold-signal bandwidth functions were almost identical at pressure-spectrum levels of 70 dB and 40 dB for the two subjects in experiment II, while estimates of frequency selectivity showed poorer frequency selectivity at the 70-dB level than at 40 dB. Data from both experiments indicated that gap detection in bandlimited noise was inversely related to signal bandwidth and that gap detection did not vary significantly with changes in signal frequency over the range of 600 to 4400 Hz. Over the range of frequencies investigated, the results indicated no clear relation between gap detection for noise stimuli and peripheral auditory filtering.

Adult↗

PubMed1992

Cochleovestibular nerve compression syndrome. I. Clinical features and audiovestibular findings.

Cochleovestibular nerve compression syndrome (CNCS) is the term used to describe a group of audiovestibular symptoms thought to be due to a vessel compressing the cochleovestibular nerve. These symptoms include recurrent vertigo, continuous disequilibrium and acquired motion intolerance. Recently, Moller reported that CNCS can be diagnosed based on abnormalities in the auditory brainstem response (ABR). After specifically excluding all other vestibular disorders, 63 patients with symptoms suggestive of CNCS were identified. These patients were systematically evaluated with a standard neurotologic test battery, and the results were reviewed retrospectively. Hearing loss was found in 51 (81%) of 63 cases, including 33 cases of unilateral high-frequency loss and 14 cases of middle-frequency loss. ABR data were interpreted with respect to Moller's criteria, and abnormal studies were found in 42 (75%) of 56 cases. Abnormal electronystagmograms were found in 57 (93%) of 61 cases. Thirteen of the patients subsequently underwent a posterior fossa procedure for vertigo and, vessels were found in contact with the cochleovestibular nerve in 11 of 13 cases. The results of this study suggest that the majority of CNCS patients have neurotologic test findings that suggest an abnormality of the cochleovestibular nerve. The results and their implications are discussed.

Acoustic Impedance Tests↗

PubMed1992

Comparison of Etymotic insert and TDH supra-aural earphones in auditory brainstem response measurement.

There are few systematic comparisons of Etymotic ER-3A insert earphones versus supra-aural earphones in auditory brainstem response (ABR) measurement. We compared ER-3A insert earphones and two types of supra-aural earphones (TDH-39P and TDH-49P) in a group of normal hearing adults. Acoustic analyses revealed spectral and temporal differences among earphones. Behavioral and ABR thresholds to click stimuli were slightly elevated with the ER-3A compared to the TDH earphones. The ER-3A earphones produced a latency delay, relative to the TDH earphones, that varied from about 0.8 to 1.0 msec, and increased at lower stimulus intensity levels. In addition, ABR wave I amplitude was significantly reduced with the ER-3A earphone. Based on these data, we recommend collection of normative data with the ER-3A earphones prior to their use in ABR measurement.

Acoustic Stimulation↗

PubMed1992

Near-infrared spectrophotometry: a new dimension in clinical chemistry.

The near-infrared (NIR) spectral region (700-2500 nm) is a fertile source of chemical information in the form of overtone and combination bands of the fundamental infrared absorptions and low-energy electronic transitions. This region was initially perceived as being too complex for interpretation and consequently was poorly utilized. Advances in chemometric techniques that can extract massive amounts of chemical information from the highly overlapped, complex spectra have led to extensive use of NIR spectrophotometry (NIRS) in the food, agriculture, pharmaceutical, chemical, and polymer industries. The application of NIRS in clinical laboratory measurements is still in its infancy. NIRS is a simple, quick, nondestructive technique capable of providing clinically relevant analyses of biological samples with precision and accuracy comparable with the method used to derive the NIRS models. Analyses can be performed with little or no sample preparation and no reagents. The success of NIRS in any particular case is determined by the complexity of the sample matrix, relative NIR absorptivities of the constituents, and the wavelengths and regression technique chosen. We describe the general approach to data acquisition, calibration, and analysis, using serum proteins, triglycerides, and glucose as examples.

Algorithms↗

PubMed1991

Otitis media with effusion in children. Binaural hearing before and after corrective surgery.

The masking-level difference (MLD) was investigated in a group of children having no known history of ear disease, and a group of children having a history of otitis media with effusion and hearing loss. The MLD is a psychoacoustic measure of the sensitivity of the auditory system to subtle interaural difference cues of time and amplitude and relates to the ability of the listener to detect and to recognize signals in noisy backgrounds. In the otitis media with effusion group, MLDs were measured both before and 1 and 3 months after the placement of pressure equalization tubes. The MLDs were often abnormally small in the otitis media with effusion group before surgery, when hearing loss was present. Significantly, MLDs sometimes remained abnormally small after surgery (after normal hearing had returned). The postsurgery MLD was particularly likely to be abnormally reduced in subjects who had experienced asymmetric losses of hearing.

Acoustic Impedance Tests↗

PubMed1991

Notched-noise measures of frequency selectivity in adults and children using fixed-masker-level and fixed-signal-level presentation.

Three experiments were performed to examine the development of frequency selectivity and to attempt to separate peripheral versus central contributions to frequency selectivity. In Experiment 1, frequency selectivity was examined in 4-year-old children, 6-year-old children, and adults, using a fixed-masker-level, notched-noise masking method. Thresholds were determined in a no-notch condition and in conditions in which the notchwidth was 0.3 times the center frequency (0.3 x fc) or 0.6 x fc. The results for the adults and 6-year-olds were similar, but the notched-noise functions of the 4-year-old listeners were relatively shallow. These results were consistent with an interpretation that frequency selectivity is relatively poor in 4-year-old listeners; however, the results of the 4-year-old listeners might also be accounted for in terms of poor processing efficiency. For example, the children may require a relatively high level of signal-related excitation in order for detection to occur. If the growth of excitation is steeper in the no-notch condition than in notched-noise conditions, then thresholds in the notched-noise conditions might be elevated because of poor processing efficiency rather than poor frequency selectivity. This interpretation is consonant with past data showing that the growth of loudness of partially masked signals steepens as a function of increasing masker level: The masker level at the output of the auditory filter centered on the signal frequency would be less for the notched-noise masker than for the masker having no notch. In Experiment 2 the growth of loudness was examined for three adult listeners in the no-notch condition and the 0.6 x fc notched noise. Results showed a steeper growth of loudness in the no-notch case. In Experiment 3, a notched-noise measure of frequency selectivity was used in which the signal level was fixed at 15 dB SL and the masker level was varied adaptively. In this method the noise level at the output of the auditory filter centered on the signal should theoretically be constant over the different notch conditions. Adult and 4-year-old listeners were tested. The notched-noise functions were similar between the adult and 4-year-old listeners. This result supports an interpretation that the shallow notched-noise, fixed-masker-level functions of 4-year-old children may be due to poor processing efficiency rather than to poor peripheral frequency selectivity.

Adult↗

PubMed1991

Relative contributions of envelope maxima and minima to comodulation masking release.

Comodulation masking release (CMR) is a phenomenon that demonstrates the sensitivity of the auditory system to across-frequency differences in the temporal modulation pattern of a complex waveform. In this paper, we review briefly some of the data on the physical parameters that affect CMR and describe models that have been proposed to account for CMR--namely, models based upon envelope equalization/cancellation, across-frequency envelope correlation, and "dip listening". The present literature is ambiguous with regard to the relative importance of energy in the peak and dip regions of the waveform envelope. We therefore performed a series of experiments to investigate this issue. In the first experiment, we examined CMR for signals that resulted either in a uniform increment or in uniform decrement in the masking noise centred on the signal frequency. This was accomplished by using a 20-Hz-wide noise band centred on 700 Hz as both the masker and as the signal, adjusting the phase angle between the signal and masker to either 0 degree (increment) or 180 degrees (decrement). Conditions were examined where either zero, one, two, four, or six comodulated flanking bands were present. Results indicated positive CMRs for all conditions in which a comodulated flanking band was present. CMR increased as the number of flanking bands increased for intensity increments, but not for intensity decrements. The remaining experiments examined conditions where signals were present only in masker peaks, or only in masker dips. The results of these experiments indicated relatively large CMRs when the signal occurred in dip regions, but no CMR when the signal occurred in peak regions. Whereas some of the results of the above experiments would be difficult to account for in terms of the dip listening hypothesis of CMR, the present findings did indicate that the stimulus cues that give rise to CMR appear to be derived primarily from the dip regions of the masking noise.

Adult↗

PubMed1991

Frequency resolution for diotic and dichotic listening conditions compared using the bandlimiting measure and a modified bandlimiting measure.

Two experiments were performed that examined the relation between frequency selectivity for diotic and dichotic stimuli. Subjects were eight normal-hearing listeners. In each experiment, a 500-Hz pure tone of 400-ms duration was presented in continuous noise. In the diotic listening conditions, a signal and noise were presented binaurally with no interaural differences (So and No, respectively). In the dichotic listening conditions, the signal or noise at one ear was 180 degrees out-of-phase relative to the respective stimulus at the other ear (S pi and N pi, respectively). The first experiment examined frequency selectivity using the bandlimiting measure. Here, signal thresholds were determined as a function of masker bandwidth (50, 100, 250, 500, and 1000 Hz) for SoNo, S pi No, and SoN pi listening conditions. The second experiment used a modified bandlimiting measure. Here, signal thresholds (So and S pi) were determined with a relatively narrow No band of masker energy (50 Hz wide) centered about the signal. Then, a second No narrow-band masker (30 Hz wide) was added at another frequency region, and signal thresholds were reestablished. The results of the two experiments indicated that listeners process a wider band of frequencies when resolving dichotic stimuli than when resolving diotic or monotic stimuli. The results also indicated that the bandlimiting measure may underestimate the spectral band processed upon dichotic stimulation. Results are interpreted in terms of an across-ear and across-frequency processing of waveform amplitude envelope.

Acoustic Stimulation↗

PubMed1991

Some effects of auditory grouping factors on modulation detection interference (MDI).

The ability to detect the existence of amplitude modulation at a target frequency is reduced when amplitude modulation exists at a flanking frequency. This effect has been termed modulation detection interference (MDI) [Yost and Sheft, J. Acoust. Soc. Am. 85, 848-857 (1989)]. One explanation for MDI holds that the masking and target frequencies are grouped together by the auditory system such that it is difficult to analyze the modulation at each frequency separately. The present study investigated conditions where the asynchrony of temporal gating of the target and flanking frequencies was manipulated in order to make the frequencies more or less likely to be grouped together by the auditory system and perceived as originating from a single putative source. A second experimental manipulation attempted to perceptually segregate the masking and target frequencies on the basis of harmonicity or spectral proximity. The results of the experiments indicated that manipulations that were intended to enhance the segregation of the masking and target frequencies reduced the magnitude of MDI effects. This generally supported an interpretation that MDI is related in some way to auditory grouping. A final experiment was performed in which the subject had to detect the presence of amplitude modulation, but also had to identify which of two frequency components carried the modulation. Subjects were often poor in discriminating which of two frequencies was amplitude modulated, even when the modulation itself was clearly audible. It was concluded that part of the MDI effect might be due to the poor ability of the auditory system to associate modulation with the carrier of the modulation.(ABSTRACT TRUNCATED AT 250 WORDS)

Acoustics↗

PubMed1990

Predicting binaural hearing after stapedectomy from presurgery results.

Past research has indicated that binaural hearing abilities are not always normal in patients having otosclerosis who have received bilaterally normal pure-tone thresholds through stapedectomy. This study investigated whether poststapedectomy performance on the binaural masking-level difference test could be predicted from presurgery tests in which the two ears were stimulated at an equal sound pressure level and at an equal sensation level. Results indicated that (1) binaural hearing usually improved following stapedectomy, though some patients maintained abnormally poor binaural hearing even though postsurgery pure-tone thresholds were normal; and (2) prediction of postsurgery results was poor, with postsurgery results often being underestimated from presurgery results. Results are interpreted in terms of possible forms of auditory deprivation and acoustic crossover.

Adult↗

PubMed1990

Frequency selectivity and comodulation masking release in adults and in 6-year-old children.

Frequency selectivity and comodulation masking release (CMR) for a 1000-Hz signal frequency were examined in 6-year-old children and adults. An abbreviated measure of frequency selectivity was also conducted for a 500-Hz signal. Frequency selectivity was measured using a notched-noise masking method, and CMR was measured using narrow bands of noise whose amplitude envelopes were either uncorrelated or correlated. There were 6 listeners in each age group. No differences were observed between the adults and children for either auditory measure. Similarly, no differences were observed in the ability to detect a pure-tone signal in a relatively wideband noise masker. When the masking noise was narrowband, however, the masked thresholds of the children were higher than those of the adults. Two characteristics that distinguish narrowband noise from wideband noise are: (1) narrowband noise has a pitch quality corresponding to its center frequency, whereas wideband noise does not have definite pitch; (2) the intensity fluctuations are relatively greater in narrowband noise than in wideband noise. This may suggest that 6-year-old children have a reduced ability to detect signals in noise backgrounds where the signal has perceptual qualities similar to the noise, or in noise backgrounds having a high degree of fluctuation.

Acoustics↗

PubMed1990

Feasibility of auditory event-related potential measurement in brain injury rehabilitation.

Measurements of auditory event-related potentials (AERPs) from brain injury rehabilitation patients may provide information on neural function related to cognitive processes important to the recovery of social and intellectual skills. The present study investigated the feasibility of measuring AERPs from 50 brain injury rehabilitation inpatients at various stages of cognitive recovery including comatose to automatic-appropriate function. Patients from levels II through VII on the Rancho Los Amigos Scale of Cognitive Function were studied. Results indicated that waveforms showing N1, P2, N2, and P3 components could be recorded from individual patients at each of the RLAS levels we studied, except level IV where only 1 patient was tested. However, considerable variability in waveforms was also observed at each scale level. No statistically significant relationships were demonstrated between AERP components and all other evoked potential, central auditory, and audiometric test results for 30 patients at RLAS level VII (automatic-appropriate). Overall results suggested a need for research focused on electrophysiologic and behavioral measures that can be used in conjunction to better describe auditory function and prognosis in brain injury patients.

Adolescent↗

PubMed1990

Effects of flanking band proximity, number, and modulation pattern on comodulation masking release.

Comodulation masking release for a 700-Hz pure-tone signal was investigated as a function of the number and spectral positions of 20-Hz-wide comodulated flanking bands. In the first experiment, all stimuli were presented diotically. CMR was examined as a function of the number of flanking bands present, in conditions where the bands were arranged symmetrically around the signal frequency, were below the signal frequency, or were above the signal frequency. The number of flanking bands ranged from one to eight, and the magnitude of the diotic CMR ranged from approximately 5-16 dB. The results indicated: (1) bands closer to the signal resulted in larger masking release, and (2) more bands gave rise to larger CMR (but with diminishing returns above two flanking bands). Two additional sets of diotic conditions were examined and compared to the condition where all eight comodulated flanking bands were present: In one set of conditions, two of the eight flanking bands were removed; in the other set of conditions, two of the eight flanking bands were replaced with bands (termed "deviant" bands) that were not comodulated with respect to the other bands. There was very little effect of reducing eight bands to six, even when the removed bands were relatively near the signal frequency; however, CMR was substantially reduced when deviant bands were introduced, particularly when the deviant bands were placed relatively near the signal frequency. These reductions in CMR were slightly greater when each of the deviant bands had a unique modulation pattern (bideviant bands) than when the two deviant bands themselves shared the same modulation pattern (codeviant bands). In the second experiment, dichotic conditions were examined where the number and spectral positions of the flanking bands in the nonsignal ear were varied (the signal ear received only a 20-Hz-wide noise band centered on the signal frequency). The magnitude of the dichotic CMR ranged from approximately 2-10 dB, depending on condition. Effects of proximity and the number of flanking bands were similar to the effects obtained in diotic conditions. For both the diotic and the dichotic data, the effects of proximity were more consistent with an interpretation based upon across-channel processing than upon a within-channel interaction. The results obtained using deviant bands indicate that it is difficult for the auditory system to disregard the modulation pattern of flanking bands that differ from the modulation pattern of the on-signal band, particularly if such bands are proximal to the signal frequency.

Acoustic Stimulation↗

PubMed1990

NoSo and NoS pi detection as a function of masker bandwidth in normal-hearing and cochlear-impaired listeners.

NoSo and NoS pi detection thresholds for a 500-Hz pure-tone signal were measured as a function of masking noise bandwidth in normal-hearing and cochlear hearing-impaired subjects. NoSo and NoS pi critical bands were derived from the bandlimited noise functions. A notched noise measure of the monaural critical band was also obtained for each ear. One hypothesis tested was that an asymmetrical monaural critical band would result in a relatively steep improvement of the NoS pi detection threshold as a function of decreasing masker bandwidth and would, therefore, be associated with a wider binaural critical band. This was hypothesized because the outputs of the left and right auditory filters would be more decorrelated the greater the interaural difference in the monaural critical band. However, as the noise bandwidth was narrowed, the decorrelation would lessen, resulting in a relatively steep improvement in NoS pi detection. Results indicated that the masking level difference (MLD) was smaller and that the monaural critical bands were generally wider in cochlear-impaired listeners. NoSo and NoS pi critical bands were somewhat larger in the cochlear hearing-impaired listeners having relatively wide monaural critical bands. There was a significant correlation between monaural critical band asymmetry and the NoS pi critical band; however, this correlation was insignificant when a control was employed for the critical band in the worse ear. Therefore, the present results did not support a strong association between monaural critical band asymmetry and the width of the NoS pi critical band.

Attention↗

PubMed1990

The effect of signal-frequency uncertainty on comodulation masking release.

The aim of this study was to examine whether the scheme of across-frequency comparison underlying comodulation masking release (CMR) is sensitive to the placement of the signal in the array of comodulating bands. This was addressed using the paradigm of signal-frequency uncertainty. In the first experiment, maskers were constructed of linearly spaced sinusoidally amplitude-modulated tones, and the signal was a pure tone presented at one of five frequencies. A small uncertainty effect was observed for the noncomodulated masker, but no significant effect was observed for the comodulated masker. In the second experiment, the maskers were constructed of logarithmically spaced noise bands, and the signal was a pure tone presented at one of seven frequencies. In these conditions, an uncertainty effect was observed in both noncomodulated and comodulated maskers, which was larger than that observed in experiment 1. The results were interpreted as indicating that the mechanism of across-frequency comparison underlying CMR is sensitive to signal location.

Acoustic Stimulation↗