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Biomedical subjects

J W Henderson

Publications and source records attributed to J W Henderson.

At least 19 recordsLinked to original sources
PubMed1991

Extracellular deposition of eosinophil major basic protein in orbital histiocytosis X.

Although eosinophils are prominent in orbital lesions of patients with histiocytosis X (Langerhans' cell histiocytosis), little is known of their pathogenic significance in the disease. To determine whether eosinophils degranulate and deposit toxic proteins in orbital histiocytosis X, the authors examined lesions by indirect immunofluorescence for localization of the core granule protein (major basic protein) outside of eosinophils. Four patients with histiocytosis X were studied: three with eosinophilic granuloma and one with Hand-Schüller-Christian disease. Tissue eosinophilia was prominent in all specimens; striking extracellular deposition of eosinophil major basic protein was noted in three patients, and focal deposition was present in the fourth patient. Orbital specimens obtained at autopsy from patients without orbital disease were studied as control specimens; no tissue eosinophilia or deposition of eosinophil major basic protein was observed. These findings indicate that eosinophils likely degranulate in lesions of orbital histiocytosis X and may participate in the pathogenesis of the disease.

Adolescent↗
PubMed1990

Clinical course of an incompletely removed cavernous hemangioma of the orbit.

Cavernous hemangioma is a frequent tumor of the orbit in adults. Its complete removal results in dramatic relief of proptosis. The clinical course of an incompletely removed cavernous hemangioma is seldom recorded in the ophthalmic literature. The authors report the behavior of such a tumor that was observed during an 18-year period. Serial computed tomography (CT) documented a long period of slow growth, followed by a shorter interval of arrest, with eventual involution of tumor and relief of proptosis. No treatment was administered during observation.

Adult↗
PubMed1989

T-cell lymphoma of the orbit.

In a 52-year-old man with drooping of the right upper eyelid and a palpable mass in the superior temporal quadrant of the right orbit, a biopsy specimen revealed diffuse mixed-type lymphoma with immunostaining evidence of a helper T-cell phenotype. No other foci of lymphoma were found. The orbital lesion was treated with irradiation (total dose, 4,200 cGy administered in 20 treatments). At 4 1/2 years after treatment, the patient had had no recurrence.

Humans↗
PubMed1989

Orbital exenteration at the Mayo Clinic. 1967-1986.

Orbital exenteration was performed in 102 patients at the Mayo Clinic during the 20-year period from 1967 through 1986. The surgical procedure was performed for mucormycosis in one patient and for pain and deformity after a severe facial burn in another; in the remaining 100 patients, exenteration was used to treat a neoplastic disorder. Although 19 different neoplasms were encountered, squamous cell carcinoma, basal cell carcinoma, and melanoma constituted 70% of the total. In 82 patients with no known residual tumor or metastases at operation, the 1-year survival rate was 88.6%, the 5-year rate was 56.8%, and the 5-year rate free of recurrence or metastases was 48.3%. In 18 patients with known residual tumor or metastases at exenteration, 55.0% were alive 1 year postoperatively, and the 5-year survival rate was 25.8%. Unusual findings in this series included two patients with metastatic basal cell carcinoma and one patient with a metastatic thyroid Hürthle cell carcinoma.

Adolescent↗
PubMed1985

Facial nerve akinesia.

In ophthalmology, increasing attention has been directed to methods of local anesthesia and akinesia that provide complete analgesia and immobilization of the eye conducive to work with the surgical microscope, particularly in operations for cataracts. The volume of anesthetic agent often used to achieve these goals may approach the toxic level of the drug in some patients. A method of producing akinesia of the temporal, zygomatic, and buccal divisions of the facial nerve that requires only a small volume of anesthetic is described. In our experience, this method can, in many cases, provide akinesia of the orbicularis oculi equal in effect to some established methods of infiltrative akinesia that require large doses of anesthetic.

Anesthesia, Local↗
PubMed1985

Management of blepharospasm.

From 1950 through 1984, 123 patients underwent surgical treatment of blepharospasm at the Mayo Clinic. During this period, four different operations (proximal and distal neurectomy and two types of myectomy) were used. Significant recurrent or residual blepharospasm was observed more frequently (p less than 0.01) and need for subsequent operations was greater (p less than 0.01) among patients who had undergone distal neurectomy than among those who had had myectomy. These data support the view that myectomy is a more effective procedure than neurectomy. Initial results with botulinum toxin injection seem to indicate that it is an effective short-term treatment for blepharospasm. However, its long-term efficacy and safety need further study, as does the role it should play in combination with myectomy.

Adult↗
PubMed1985

Management of blepharospasm.

From 1950 through 1984, 123 patients underwent surgical treatment of blepharospasm at the Mayo Clinic. During this period, four different operations (proximal and distal neurectomy and two types of myectomy) were used. Significant recurrent or residual blepharospasm was observed more frequently (P less than 0.01), and need for subsequent operations was greater (P less than 0.01), among patients who had undergone distal neurectomy than among those who had had myectomy. These data support the view that myectomy is a more effective procedure than neurectomy. Initial results with botulinum toxin injection seem to indicate that it is an effective short-term treatment for blepharospasm. However, its long-term efficacy and safety need further study, as does the role it should play in combination with myectomy.

Adult↗
PubMed1978

Primary orbital hemangiopericytoma. An aggressive and potentially malignant neoplasm.

The aggressive behavior and potentially lethal nature of some hemangiopericytomas primary in the orbit are generally unknown in the field of ophthalmology. The neoplasm is not common in the orbit, and reports in the ophthalmic literature usually describe single-case examples of the neoplasm with short-term periods of observation. Two in our series of 11 patients died of metastasis 35 years after the onset of symptoms. Another patient died of local orbital recurrence with secondary invasion of the intracranial vault, which was possibly related to heavy radiotherapy. In the orbit, those neoplasms frequently are circumscribed in their growth. Complete and intact removal is recommended. If the tumors are incompletely excised, recurrences are frequent but may not be manifest as long as ten years after surgery.

Adult↗
PubMed1978

Optic nerve infarction.

In three cases infarction in the inferotemporal prelaminar portion of the optic disk resulted in shallow cupping and arcuate visual field defects. Such changes occurred acutely, were not progressive, and required no treatment.

Adult↗
PubMed1977

Optic nerve infarction.

A specific type of optic disc damage and visual field loss has been emphasized. The changes occur acutely at the inferotemporal disc margin and do not seem to progress. Such patients have normal intraocular pressures. We have termed this entity "acute inferotemporal prelaminar optic disc infarction syndrome" in an effort to avoid using the word glaucoma. Although similar events can occur in glaucomatous eyes, we feel that such changes are not progressive and that sophisticated diagnostic studies should be avoided. Three cases are presented as examples.

Adult↗
PubMed1977

Primary intraorbital meningioma with intraocular extension.

Intraocular invasion of a meningioma primary in the sheath of the intraorbital portion of the optic nerve was noted in a 54-year-old woman with a 16-year history of visual loss. Seventeen additional cases of intraglobal extension of intraorbital meningioma were found in the literature. The clinical features and histopathologic findings of the total cases are compared and reviewed. We suggest that the mode of penetration is along the course of the posterior ciliary vessels as they penetrate the sclera.

Blindness↗
PubMed1976

En bloc removal of intrinsic neoplasms of the lacrimal gland.

The management of intrinsic neoplasms primary in the lacrimal gland is of serious concern because some of the most malignant primary tumors of the orbit occur in this glandular structure and present surgical techniques may easily disseminate the neoplasm and contribute to death or recurrences. We propose a surgical approach in which the tumor and adjacent adnexa are removed in a one-stage procedure, that is, an en bloc resection of the neoplasm, its periorbital base, and surrounding bone. This technique will minimize seeding of the tumor, provide a more complete eradication of the neoplasm without loss of the eye, and assure either a cure or a longer interval free of local recurrences or metastasis than is presently attainable.

Carcinoma, Adenoid Cystic↗
PubMed1976

En bloc removal of intrinsic neoplasms of the lacrimal gland.

The management of intrinsic neoplasms primary in the lacrimal gland is of serious concern because (1) some of the most malignant primary tumors of the orbit occur in this glandular structure and (2) present surgical techniques may easily disseminate the neoplasm and contribute to death or recurrences. We propose a surgical approach in which the tumor and adjacent adnexa are removed in a one-stage procedure, that is, an en bloc resection of the neoplasm, its periorbital base, and surrounding bone. This technique will minimize seeding of the tumor, provide a more complete eradication of the neoplasm without loss of the eye, and hopefully, assure either a cure or a longer interval free of local recurrences or metastasis than is presently attainable.

Basal Cell Carcinoma↗