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Biomedical subjects

J W Hinton

Publications and source records attributed to J W Hinton.

25 records · Page 2Linked to original sources
PubMed1978

Anomalies of cyclic AMP excretion in some abnormal offenders.

It is now well established that the metabolic sequeale of catecholamine secretion are mediated via cyclic nucleotides. Recent studies have indicated changes in the pattern of catecholamine secretion correlating with convictions for violence in maximum security hospital detainees. This study of the excretion rate of urinary cyclic AMP in this group of patients failed to show a correlation between adrenaline or noradrenaline and cyclic AMP secretion. However, subjects convicted of sexual offences showed a significantly greater cyclic AMP excretion than other patients and normal controls. These results are discussed in terms of the possible modification of receptor sensitivity and influence of alternative agonists such as testosterone.

Cyclic AMP↗
PubMed1978

Plasma catecholamines, stress and aggression in maximum security patients.

Investigations into the stress response of patients committed to a special hospital for criminally deviant offences have identified a group of sympathetically hypoactive patients who excrete more noradrenaline and less adrenaline in the urine than either the remaining hospital population or control subjects, during conditions of stresser anticipation. Further investigation of these patients has shown that similar differences in plasma catecholamines exist, and that the group of patients characterised by this imbalance tend to have been committed for the most physically violent crimes.

Adolescent↗
PubMed1977

Differential effects on test stress on the heart rates of extraverts and introverts.

A mental arithmetic task was administered to 39 subjects under conditions which imposed social stress. Using the relaxed state to provide a baseline, changes in heart rate and finger blood volume pulse were recorded. The subjects were divided to obtain groups with extreme scores on Eysenck's PEN scales, and the groups were compared on the two psychophysiological measures. Contrary to Eysenck's theory of Autonomic Lability as the neurological basis of N, the high N scoring group was not differentiated from the low N group by change in level of sympathetic activity as indicated by blood volume pulse, while, on the heart-rate measure, introverts showed a large increase and extraverts considerably less: there was no overlap between groups (p less than 0.001). It was concluded that extraverts exhibit greater parasympathetic activity relative to sympathetic arousal under this stress condition.

Arousal↗
PubMed1977

Abnormality of catecholamines balance relating to social deviance.

Approximately a quarter of maximum security hospital patients convicted of highly deviant crimes exhibited low 'anxiety-type' psychophysiological responsivity to stressors together with an abnormal catecholamine balance during stressor anticipation which resulted in noradrenalin to adrenalin ratios in excess of 5.5, an abnormally high value not exceeded by any control subjects and a result which is significant (p less than 0.005).

Adolescent↗