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J W Legge

Publications and source records attributed to J W Legge.

13 recordsLinked to original sources
PubMed1985

Dupuytren disease.

The recent increased interest in Dupuytren disease by basic scientists as well as clinicians has led to extensive investigations into the pathophysiology and etiology of this complicated condition. Our present knowledge of the basic scientific aspects of the disease, as well as methods of management, have been summarized in this chapter. Answers being sought in Dupuytren disease will certainly go a long way into solving problems of wound healing. However, until then, the methods of treatment of Dupuytren disease will remain varied, and unexpectedly poor results will still crop up all too frequently. At present the best defense against this is to pay particular attention to the anatomic variations in the disease, perform meticulous surgical procedures, and supervise careful postoperative management.

Collagen↗
PubMed1982

Optimal dietary conditions for hemoccult testing.

Preliminary rehydration of Hemoccult II slides increases slide sensitivity for blood and lowers the false-negative rate for colorectal cancer. To test the effect of this modification on the false-positive rate due to peroxidase-containing foods, 156 healthy young subjects crossed between diets of differing peroxidase content. Hemoccult II slides were prepared in duplicate for testing with and without rehydration. When developed without rehydration, only seven (0.4%) of 1856 slides were positive, the positive results occurring with challenge diets containing 250 g rare red meat. With preliminary rehydration, 53 (5.7%) of 926 slides were positive, in 26 (17%) of the 156 subjects on a challenge diet that included rare red meat and uncooked fruit and vegetables. Well-cooked red meat also gave positive tests, Diets excluding red meat but with large quantities of uncooked fruit and vegetables produced only five positive results in 314 rehydrated tests, in 3 of 53 subjects. On a strict low-peroxidase diet, two of 310 tests, in 2 of 52 subjects, were positive. Rehydration of Hemoccult slides and exclusion of red meat and certain other high-peroxidase foods should give optimal sensitivity and specificity for colorectal cancer detection. The effect of these conditions on yield of lesions and false-positive rates should be tested in screening programs.

Adult↗
PubMed1981

A study of Dupuytren's tissue with the scanning electron microscope.

This study was designed to determine if structural changes in the palmar fascia in Dupuytren's disease, as viewed by the scanning electron microscope, might provide some information about the pathogenesis of this disease. The palmar fascia from seven uninvolved hands and from 21 patients with Dupuytren's disease was examined. There were distinct differences between normal and diseased collagen. The diseased tissue showed collagen that was more tightly bound and had a shorter wave pattern. In the Dupuytren's tissue the waves were frequently in a helix, but this was never seen in the normal tissue. The most striking differences were noted in the nodule, presumably because it appears first, followed by the cord proximal to the nodule (pretendinous cord). Similar but less obvious changes were noted in the cord distal to the nodule (central cord) presumably because it is last to form. These observations suggest a mechanism of contraction. The short wave length and helix formation of the collagen indicate shortening. If the concept of the myofibroblast as a contractile cell is accepted, the contraction of these cells in stepwise fashion could produce the changes in the structure of the collagen that have been observed and result in joint contracture.

Collagen↗
PubMed1980

Prediction of results of treatment of Dupuytren's disease.

Although Dupuytren's disease is common it is still not fully understood. A series of patients has been assessed by multiple regression analysis from which "outcome standards" have been formulated. It is anticipated that this method of analysis will further our understanding of the disease when greater numbers of patients are added to the study. As well, the application of an "outcome standard" to a given patient should reduce the number of unexpectedly poor results obtained and expose errors in the primary management of those patients.

Aged↗
PubMed1943

Liver catalase.

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Journal Article↗