[Immunostimulation: wishful thinking or reality?. Interview by Lydia Schaffner].
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Adolescent↗
Biomedical subjects
J W Müller-Schoop
Publications and source records attributed to J W Müller-Schoop.
Chlamydia trachomatis as possible cause of peritonitis and perihepatitis in young women.
Of 11 young women with acute peritonitis proved by laparoscopy, seven of whom also had perihepatitis, nine had serological evidence of recent infection with Chlamydia trachomatis; In five of these nine patients high antibody titres to chlamydiae were found without laboratory evidence of gonococcal infection, while the other four had evidence of simultaneous gonococcal infection. C trachomatis may play an important part in peritoneal inflammation previously attributed only to gonococci.
Adolescent↗
Drug-induced pseudolupus.
Of fifteen patients with pseudolupus (a syndrome characterised by recurrent fever, myalgia, arthralgia, pleuritis, pulmonary infiltrates, pericarditis, myocarditis, and by mitochondrial antibodies in the absence of nuclear antibodies), all had been treated with "Venocuran", one of a great number of drugs used for venous diseases. This drug, available in twenty countries under various names, contains phenopyrazone, horse-chestnut extract, and cardiac glycosides extracted from various plants. Further studies revealed that up to 90% of long-term users of venocuran acquired mitochondrial antibodies. This was not true for patients with venous diseases being treated with other drugs. About 30% of long-term users of venocuran might experience prodronal symptoms, such as myalgia and arthralgia, while more than 10% could develop the full disease.
Antibodies↗
[Pseudolupus: a severe side effect of a varicose vein drug?].
Among 7 patients with "pseudolupus" (a lupus erythematodes-like syndrome with antimitochondrial antibodies) an unusual incidence of varicose veins was noted. Reexamination of their histories revealed that all had been taking the same rather uncommon drug "Venocuran" for a prolonged period before developing the typical symptoms of this disease (recurrent fever, perimyocarditis, myalgias). They appeared on average 7 months after initiation of drug therapy and lasted for weeks or months even when the drug was promptly withdrawn. It is probable, though by no means certain, that one or several components of this drug play an important role in the pathogenesis of this immunologically distinct disease.
Adult↗
Functional studies of Peyer's patches: evidence for their participation in intestinal immune responses.
The pattern of responsiveness of lymphocytes from Peyer's patches, spleen, mesenteric, and inguinal nodes of guinea pigs was compared after oral and parenteral immunization. After oral immunization with BCG, Peyer's patch lymphocytes showed the best in vitro proliferative responses to PPD (tuberculin). Responsiveness to Clostridia, normal constituents of the intestinal microflora, also was significant in Peyer's patches, and low or absent in the other lymphoid tissues examined. In animals immunized parenterally with heat-killed Mycobacterium tuberculosis, lymphocytes from the spleen reacted best to PPD and those from Peyer's patches least. Selective elimination of B or T cells from PPD-reactive Peter's patch lymphocyte populations showed that the T-cell-rich fraction remained responsive to PPD, the B cell-rich fraction became unresponsive; but both fractions reacted to Clostridia. We conclude from this experiment that a functional T cell population is present in these organs. Peyer's patches in the guinea pig are immunocompetent lymphoid organs which seem to be primarily engaged in immune responses to antigens presented from the intestinal lumen.
Animals↗