STUDY OF A PATIENT WITH 48-HOUR MANIC-DEPRESSIVE CYCLES. II. STRONG POSITIVE CORRELATION BETWEEN ENDOCRINE FACTORS AND MANIC DEFENSE PATTERNS.
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Biomedical subjects
Publications and source records attributed to J W MASON.
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The rate at which monkeys pressed a lever and avoided shocks was manipulated in several ways. Measurements were also made of their plasma levels of 17-hydroxycorticosteroids. The rate at which the animals pressed the lever and the frequency with which they received shocks were both implicated as determiners of the steroid levels.
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In association with conditioned avoidance sessions of 72 hours' duration, monkeys showed a response pattern characterized by increased levels of 17-hydroxy-corticosteroids and decreased levels of pepsinogen during the stress period, with a marked and prolonged elevation of pepsinogen levels occurring during the recovery period.
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