Long-term infusion of amounts of angiotensin insufficient at the beginning to raise arterial pressure results, after several days in sustained arterial hypertension in unanesthetized dogs. This hypertension is to a large degree dependent on environmental stimuli, and results chiefly from increase in peripheral resistance. As in dogs with renal hypertension, there is increased pressor responsiveness to tyramine. This indirect action of angiotensin to increase total peripheral resistance and arterial pressure by an action on the sympathetic nervous system, along with an upward resetting of the carotid sinus buffering mechanism, might logically account for the neural component of chronic renal hypertension. Such a proposal integrates the humoral and neural elements of the mosaic describing the mechanisms of tissue perfusion.

Angiotensin II↗

PubMed1965

Autonomic regulation of arterial pressure responses.

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Anesthesia, Intravenous↗

PubMed1952

Increased resistance to autonomic ganglionic blockade by tetraethylammonium chloride and pentamethonium iodide in experimental neurogenic hypertension.

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Autonomic Nervous System Diseases↗