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Biomedical subjects

J W Mosley

Publications and source records attributed to J W Mosley.

At least 109 records · Page 6Linked to original sources
PubMed1975

Serologic characterization of patients with two episodes of acute viral hepatitis.

Since testing for serologic markers of hepatitis B virus (HBV) became routine, we have observed in our hospital 28 patients with two distinct episodes of illnesses, each of which was compatible with acute viral hepatitis. We found no distinctions between the first and second bouts with respect to clinical characteristics, abnormalities of liver function or epidemiologic background. Testing of specimens obtained during each of the two acute episodes, the interval between the two episodes and the period subsequent to the second by sensitive procedures for hepatitis B surface antigens (HBsAg) and their corresponding antibodies (anti-HBs) permitted the following classification: 13 of 28 patients experienced first bouts serologically classifiable as due to HBV; 11 patients had second bouts serologically classifiable as due to HBV; 2 patients had two episodes both which were serologically indeterminate; and 2 patients had two bouts neither of which appeared compatible with HBV infection by present criteria. No patient had a second episode for which the HB2Ag and anti-HBs data suggested HBV recurrence or reinfection. This evidence does not favor the speculation that HBV can account for repeated episodes of acute icteric hepatitis.

Acute Disease↗
PubMed1975

Viral hepatitis as an occupational hazard of dentists.

To estimate the risk of viral hepatitis for practicing dentists, a questionnaire survey was conducted in the greater Los Angeles area among the part-time faculty of the University of Southern California School of Dentistry. An icteric episode diagnosed as hepatitis had been experienced by 11, representing 3.9% of the 285 dentists to whom questionnaires were mailed or 4.5% of the 242 respondents. All illnesses occurred after graduation from dental school, and five were after 1967. For general dentists, the minimal frequency was 2.7 (5 of 187 in the sample). Specialists with emphasis in surgical forms of dentistry had hepatitis with a significantly higher frequency: 3 of 19 oral surgeons; 1 of 13 periodontists; and 1 of 9 endodontists. The risk did not vary in this sample with the proportion of young adult patients (15 to 29 years of age) in the practice or recognizable illicit self-injection among patients. Auxiliary dental personnel seem to have a lower risk than dentists themselves. Measures to reduce the hazard are indicated, but at present these are confined to greater care in avoiding percutaneous introduction.

Adolescent↗
PubMed1975

Potency of fragmented IgG: two studies of postexposure prophylaxis in type A hepatitis.

To determine the effect of fragmentation on potency of immune globulin preparations, two comparisons were carried out. In one study, the immune globulin was derived from American plasma; in the other, the source was Israeli plasma. In each of the two studies, three materials were given to household contacts of icteric hepatitis: (1) human albumin as a placebo; (2) immune globulin with the IgG intact; and (3) immune globulin of the same lot with the IgG deliberately fragmented by added fibrinolysin. Comparable reductions in secondary attack rates were achieved with fragmented and unfragmented materials from both lots. Fragmentation, therefore, had no deleterious effect. In addition, it was found that American globulin is comparable to Israeli globulin for protection against strains of Type A hepatitis prevalent in Israel. Administration in the second half (last 15 days) of the incubation period did not reduce the frequency of icteric disease.

Child↗
PubMed1972

Viral hepatitis in Israel: the effect of canvassing physicians on notifications and the apparent epidemiological pattern.

Notifications of morbidity are frequently incomplete but they represent the only practicable way of carrying out large-scale surveillance. Studies of hepatitis in the Central District of Israel offered an opportunity of assessing the reliability of routine data. The regular canvassing of physicians resulted in a 2-3-fold increase in reports of viral hepatitis. Comparisons of rates before and after canvassing with those for an insured population within the Central District indicated that there was an improvement from 37.4% in 1960/61 to 96.2% in 1968/69. None the less, the lower (precanvassing) level of reporting adequately delineated year-to-year fluctuations in morbidity, the seasonal cycle, and age distribution. One consequence of canvassing was a distortion of the secular trend not only for hepatitis but also for some other communicable diseases.

Age Factors↗
PubMed1971

Isoniazid toxicity.

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Chemical and Drug Induced Liver Injury↗