Biomedical subjects

J W Nesbit

Publications and source records attributed to J W Nesbit.

26 records · Page 2Linked to original sources

PubMed1987

Pathological findings in a natural outbreak of aflatoxicosis in dogs.

The gross and histopathological lesions of 10 cases in a natural outbreak of aflatoxicosis amongst dogs in the Republic of South Africa are reported. The 10 cases were classified as acute (1 case), subacute (7 cases) and chronic (2 cases) on the basis of the nature, degree and extent of the following histopathological fractures: hepatocellular fatty degeneration, necrosis or regeneration; proliferation of bile ductules; accumulation of bile within the canaliculi; fibroplasia; and, mucoid degeneration, necrosis or segmental atrophy of the larger intrahepatic bile ducts. Fatty degeneration was noted grossly in the livers of all 10 cases and bile stasis in 4. Varying degrees of fibrosis were present depending on the stage of the disease. In the 2 chronic cases in which nodular regeneration was also observed fibrosis was pronounced. Other macroscopic findings included icterus, anaemia, ascites, hydrothorax, hydropericardium, anasarca, pulmonary oedema, gastro-enterorrhagia and nephrosis.

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PubMed1987

The pathology of a case of biliary atresia in a foal.

The pathological features of biliary atresia in a foal are described. A 4-week-old American Saddler foal was presented for autopsy following an illness characterised by clinical features indicative of hepatic failure. The significant macroscopical lesions occurred in the liver which was extremely enlarged, mottled in appearance and indurated. Bile stasis was evident. Lobular distinction was absent and on sectioning, large bile ducts were absent. A moderate ascites, hydrothorax and hydropericardium and a mild anasarca and intermuscular oedema accompanied the hepatic lesion. The diagnosis of biliary atresia was determined by the histo-pathological features of bile duct proliferation and extensive replacement fibrosis. The condition is compared to extrahepatic and intrahepatic biliary atresia of man and evidence is presented for regarding this case to be one of extrahepatic origin.

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PubMed1986

The pathology of a case of biliary atresia in a foal.

The pathological features of biliary atresia in a foal are described. A 4-week-old American Saddler foal was presented for autopsy following an illness characterised by clinical features indicative of hepatic failure. The significant macroscopical lesions occurred in the liver which was extremely enlarged, mottled in appearance and indurated. Bile stasis was evident. Lobular distinction was absent and on sectioning, large bile ducts were absent. A moderate ascites, hydrothorax and hydropericardium and a mild anasarca and intermuscular oedema accompanied the hepatic lesion. The diagnosis of biliary atresia was determined by the histopathological features of bile duct proliferation and extensive replacement fibrosis. The condition is compared to extrahepatic and intrahepatic biliary atresia of man and evidence is presented for regarding this case to be one of extrahepatic origin.

Animals↗

PubMed1986

The pathology of pulmonary aspergillosis in a piglet.

The pathology of pulmonary aspergillosis in a piglet is described. The dominant feature is the pneumonic process which is acute, focal, disseminated and necrotising to purulent in character. Fungal hyphae typical of the aspergilli are present within the lesions. The comparative aspects of this case and the primary invasive form of pulmonary aspergillosis in man are briefly enunciated.

Animals↗

PubMed1985

A pulmonary giant cell carcinoma in a dog.

A case of a large cell anaplastic carcinoma of the giant cell type in the lungs of a 5 year-old crossbred male Labrador is discussed. The dog was weak, depressed, febrile and markedly dyspnoeic. An intermittent moist cough and auscultable crackling rales were evident. Radiographic examination was indicative of pneumonia and pulmonic neoplasia. The dog died 36 hours after admission despite antibiotic and supportive therapy. At autopsy, the neoplasm appeared as numerous firm greyish-white nodules of varying size throughout all the lung lobes whilst in the right intermediate and diaphragmatic lobes the neoplasm was completely confluent. The microscopic features included: intra-alveolar composites of cells exhibiting considerable nuclear and cytoplasmic pleomorphism; the presence of numerous giant cells scattered throughout the tumour; the occurrence of tumour emboli within both venous and lymphatic vessels; and, metastatic foci in the bronchial and mediastinal lymph nodes. These features were considered to reflect a high degree of malignancy. Comparative and aetiological aspects of bronchogenic carcinomas in man and the dog are discussed.

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PubMed1981

Spastic paresis in two littermate pups caused by Toxoplasma gondii.

The clinical and pathological findings in 2 sibling Bloodhound pups with spastic paresis of the pelvic limbs due to toxoplasmosis are described. Macropathology consisted of bilateral atrophy of the musculature of the affected limbs. Histopathology revealed meningo-encephalitis involving the cerebellum and medulla oblongata, diffuse meningomyelitis, radiculoneuritis of the lumbar spinal nerves and polymyositis and atrophy of skeletal muscle. Epizootological investigations failed to determine the source of the infection. Dissemination of the infection by a route other than the haematogenous pathway is considered and discussed.

Animals↗

PubMed1981

Cerebellar cortical atrophy in a puppy.

A description is given of the history and neuropathology of a mongrel puppy which had suffered from cerebellar cortical atrophy. The condition was attended by intractable cerebellar ataxia and characterised by selective degeneration of the Purkinje cells of the cerebellar cortex. Cerebellar dysfunction is briefly reviewed. The lesion and possible aetiology are briefly discussed.

Animals↗

PubMedDate not supplied

Hepatic ultrasonography and pathological findings in dogs with hepatocutaneous syndrome: new concepts.

In dogs, hepatocutaneous syndrome (superficial necrolytic dermatitis) belongs to a group of syndromes in which cutaneous signs signal the presence of systemic disease. It is characterized by parakeratosis, superficial necrolysis, and basilar hyperplasia of the epidermis, in association with an unusual hepatopathy accompanied by certain metabolic derangements. Hepatocutaneous syndrome was diagnosed in 3 dogs on the basis of typical dermatologic changes and clinicopathologic findings. Hepatic ultrasonography revealed a hyperechoic network surrounding hypoechoic areas of parenchyma, resulting in a Swiss cheese-like appearance. The ultrasonographic image corresponded to the pathological findings. The liver had a nodular appearance, both grossly and microscopically; this was attributed to collapse of the areas of parenchyma surrounding the nodules, rather than to the cirrhosis and/or nodular hyperplasia reported previously.

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