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Biomedical subjects

J W Nicholson

Publications and source records attributed to J W Nicholson.

At least 19 recordsLinked to original sources
PubMed2006

Propagation of femtosecond pulses in large-mode-area, higher-order-mode fiber.

We demonstrate propagation of 14 nJ femtosecond pulses through a large-mode-area, higher-order-mode (HOM) fiber with an effective area of 2100 microm2. The pulses propagate stably in the LP07 mode of the fiber through lengths as long as 12 m. The strongly chirped pulses exiting the amplifier fiber are dechirped by the high-order-mode fiber, resulting in pulses with a peak power of 61 kW after propagation in 5 m of the positive-dispersion fiber. A small amount of self-phase modulation is observed in the compressed pulses and is described well by a nonlinear Schrödinger equation model that takes into account the measured effective area and dispersion of the HOM fiber.

Journal Article↗
PubMed2006

Fiber-laser frequency combs with subhertz relative linewidths.

We investigate the comb linewidths of self-referenced, fiber-laser-based frequency combs by measuring the heterodyne beat signal between two independent frequency combs that are phase locked to a common cw optical reference. We demonstrate that the optical comb lines can exhibit instrument-limited, subhertz relative linewidths across the comb spectra from 1200 to 1720 nm with a residual integrated optical phase jitter of approximately 1 rad in a 60 mHz to 500 kHz bandwidth. The projected relative pulse timing jitter is approximately 1 fs. This performance approaches that of Ti:sapphire frequency combs.

Journal Article↗
PubMed2006

Anomalous dispersion in a solid, silica-based fiber.

We demonstrate an all-solid (nonholey), silica-based fiber with anomalous dispersion at wavelengths where silica material dispersion is negative. This is achieved by exploiting the enhanced dispersion engineering capabilities of higher-order modes in a fiber, yielding + 60 ps/nm km dispersion at 1080 nm. By coupling to the desired higher-order mode with low-loss in-fiber gratings, we realize a 5 m long fiber module with a 300 fs/nm dispersion that yields a 1 dB bandwidth of 51 nm with an insertion loss of approximately 0.1 dB at the center wavelength of 1080 nm. We demonstrate its functionality as a critical enabler for an all-fiber, Yb-based, mode-locked femtosecond ring laser.

Journal Article↗
PubMed2006

Probing optical microfiber nonuniformities at nanoscale.

We demonstrate a novel, simple, and comprehensive method for probing optical microfiber surface and bulk distortions with subnanometer accuracy. The method employs a regular optical fiber as a probe that slides along a microfiber transmitting the fundamental mode. The fraction of radiation power absorbed in the probe depends on the local distribution of the mode propagating in the microfiber. From the measured variation of the absorbed power, we determine the variation of the effective microfiber radius, which takes into account both the microfiber radius and refractive index variations. Furthermore, we verify the cylindrical symmetry of the microfiber nonuniformities by probing the microfiber from different sides. These results explain observed transmission losses in silica microfibers and open broad opportunities for microfiber investigation.

Journal Article↗
PubMed2006

Light propagation with ultralarge modal areas in optical fibers.

We demonstrate robust single-transverse-mode light propagation in higher-order modes of a fiber, with effective area A(eff) ranging from 2,100 to 3,200 microm(2). These modes are accessed using long-period fiber gratings that enable higher-order-mode excitation over a bandwidth of 94 mm with greater than 99% of the light in the desired mode. The fiber is designed such that the effective index separation between modes is always large, hence minimizing in-fiber mode mixing and enabling light propagation over lengths as large as 12 m, with bends down to 4.5 cm radii. The modal stability increases with mode order, suggesting that A(eff) of this platform is substantially scalable.

Journal Article↗
PubMed2006

Improved stabilization of a 1.3 microm femtosecond optical frequency comb by use of a spectrally tailored continuum from a nonlinear fiber grating.

We report significant enhancement (+24 dB) of the optical beat note between a 657 nm cw laser and the second-harmonic generation of the tailored continuum at 1314 nm generated with a femtosecond Cr:forsterite laser and a nonlinear fiber Bragg grating. The same continuum is used to stabilize the carrier-envelope offset frequency of the Cr:forsterite femtosecond laser and permits improved optical stabilization of the frequency comb from 1.0 to 2.2 microm. Using a common optical reference at 657 nm, a relative fractional frequency instability of 2.0 x 10(-15) is achieved between the repetition rates of Cr:forsterite and Ti:sapphire laser systems in 10 s averaging time. The fractional frequency offset between the optically stabilized frequency combs of the Cr:forsterite and Ti:sapphire lasers is +/-(0.024 +/- 6.1) x 10(-17).

Journal Article↗
PubMed2006

The clinical repair of teeth using direct filling materials: engineering considerations.

This paper reviews the way in which teeth damaged by caries may be repaired clinically. The mechanical effects of caries are described, as are the materials available to repair the damage caused by this disease. Studies are reported which have shown that caries reduces the compressive strength of the tooth to less than 50 per cent of its original value and that, by use of appropriate materials and placement techniques, this can be restored to some 80 per cent of this value. However, very few studies have been carried out which view tooth repair from an engineering perspective. Instead, emphasis is placed on determining clinical durability of repairs. This is related to repair strength but brings in other factors, such as the oral hygiene of the patient. Despite this complication, durability studies show that modern restorative materials perform well under clinical conditions, from which it may be concluded that the repair process allows a structure to be fabricated that is essentially sound from an engineering viewpoint, even if inferior to the original tooth structure provided by nature.

Biomedical Engineering↗
PubMed2005

Stabilized frequency comb with a self-referenced femtosecond Cr:forsterite laser.

A frequency comb is generated with a Cr:forsterite femtosecond laser, spectrally broadened through a highly nonlinear optical fiber to span from 1.0 to 2.2 ,m, and stabilized using the f-to-2f self-referencing technique. The repetition rate and the carrier-envelope offset frequency are stabilized to a hydrogen maser, calibrated by a cesium atomic fountain clock. Simultaneous frequency measurement of a 657-nm cw laser by use of the stabilized frequency combs from this Cr:forsterite system and a Ti:sapphire laser agree at the 10(-13) level. The frequency noise of the comb components is observed at 1064, 1314, and 1550 nm by comparing the measured beat frequencies between cw lasers and the supercontinuum frequency combs.

Journal Article↗
PubMed2004

Supercontinuum generation in ultraviolet-irradiated fibers.

We demonstrate that UV exposure of highly nonlinear, germanosilicate fibers causes a strong change in their chromatic dispersion and can significantly alter the infrared supercontinuum generation in these fibers. By varying the level of UV exposure to the fiber, we show that the dispersion zero and the short-wavelength edge of the supercontinuum can be changed by more than 100 nm. A nonlinear Schrödinger equation model of the continuum generation in the nonlinear fiber shows that the short-wavelength behavior of the continuum is primarily controlled by changes in the fiber dispersion caused by the UV-induced change in the refractive index of the fiber core.

Journal Article↗
PubMed2004

Absolute-frequency measurements with a stabilized near-infrared optical frequency comb from a Cr:forsterite laser.

A frequency comb is generated with a chromium-doped forsterite femtosecond laser, spectrally broadened in a dispersion-shifted highly nonlinear fiber, and stabilized. The resultant evenly spaced comb of frequencies ranges from 1.1 to beyond 1.8 microm. The frequency comb was referenced simultaneously to the National Institute of Standards and Technology's optical frequency standard based on neutral calcium and to a hydrogen maser that is calibrated by a cesium atomic fountain clock. With this comb we measured two frequency references in the telecommunications band: one half of the frequency of the d/f crossover transition in 87Rb at 780 nm, and the methane v2 + 2v3 R(8) line at 1315 nm.

Journal Article↗
PubMed2004

The release of ions by compomers under neutral and acidic conditions.

Three commercial compomers have been studied for their interaction with aqueous solutions (i.e. water at pH 5.9 and lactic acid at pH 2.7). Light-cured discs of these materials (12.8 diameter x 1 mm depth; Dyract AP, Compoglass F and F2000) were prepared and stored in 5 cm(3) of either water or lactic acid at pH 2.7. After 1 week, mass changes, pH changes and ion-release were determined. For the specimens stored in water, the effect of maturation under neutral conditions was studied by continuing storage for 3 months, followed by storage in lactic acid for a further week after which ion release and pH change were determined. Student's t-test was used to determine statistical significance of any changes observed. All three cured compomers absorbed water and altered the pH of the solutions, though this was statistically significant only in lactic acid. They were found to release Na, Ca, Sr, Al, Si, P and F ions, with greater amounts being released in acidic conditions than neutral ones. More fluoride was released in acid than in water, but the proportion of free (uncomplexed) fluoride to bound (complexed) fluoride was much lower than in neutral conditions. This was attributed to the formation of strong complexes with aluminium. Maturing specimens for 3 months made very little difference to their interaction with the acid solution, except for the total release of fluoride, which was some two to three greater than from the immature specimens.

Absorption↗
PubMed2004

The effect of Coca-Cola and fruit juices on the surface hardness of glass-ionomers and 'compomers'.

The interaction of tooth-coloured dental restorative materials (a conventional glass-ionomer, two resin-modified glass-ionomers and two compomers) with acidic beverages has been studied with the aim of investigating how long-term contact affects solution pH and specimen surface hardness. For each material (ChemFil Superior, ChemFlex, Vitremer Core Build-Up/Restorative, Fuji II LC, Dyract AP and F2000) disc-shaped specimens were prepared and stored in sets of six in the following storage media: 0.9% NaCl (control), Coca-Cola, apple juice and orange juice. After time intervals of 1 day, 1 week, 1 month, 3 months, 4 months, 6 months and 1 year, solution pH and Vickers Hardness Number were determined for each individual specimen. Differences were analysed by anova followed by Student-Newman-Keuls post hoc analysis. All materials were found to reduce the pH of the 0.9% NaCl, but to increase the pH of the acidic beverages. The conventional glass-ionomers dissolved completely in apple juice and orange juice, but survived in Coca-Cola, albeit with a significantly reduced hardness after 1 year. The other materials survived in apple juice and orange juice, but showed greater reductions in surface hardness in these beverages than in Coca-Cola. Fruit juices were thus shown to pose a greater erosive threat to tooth coloured materials than Coca-Cola, a finding which is similar to those concerning dentine and enamel towards these drinks.

Beverages↗
PubMed2003

420-MHz Cr:forsterite femtosecond ring laser and continuum generation in the 1-2-micrometre range.

We demonstrate a chromium-doped forsterite femtosecond ring laser that generates 30-fs pulses at a 420-MHz repetition rate with nearly 500 mW of average power. The compact solid-state design and broad spectral output make this laser attractive for telecommunications applications in the 1.3-1.5-micrometre region. Additional spectral broadening of the laser output in highly nonlinear optical fiber leads to octave-spanning spectra ranging from 1.06 to 2.17 micrometre. The octave is reached at a level of 18 dB below the peak. The underlying optical frequency comb can be linked to existing optical frequency standards.

Journal Article↗
PubMed2003

All-fiber, octave-spanning supercontinuum.

We present an all-fiber supercontinuum source based on a passively mode-locked erbium fiber laser and a small-effective-area, germanium-doped silica fiber. The parallels between this system and the continuum generated in microstructured fibers with 800-nm pulses are discussed, and the role of dispersion is investigated experimentally. We construct a hybrid fiber by fusion splicing lengths of different-dispersion fiber together, generating more than an octave of bandwidth.

Journal Article↗
PubMed2003

The physical properties of conventional and resin-modified glass-ionomer dental cements stored in saliva, proprietary acidic beverages, saline and water.

Specimens of three conventional and one resin-modified glass-ionomer cement were prepared for both compressive strength and biaxial flexure strength determination. They were stored either in neutral media (water, saline, unstimulated whole saliva or stimulated parotid saliva) or in acidic beverages (apple juice, orange juice or Coca-Cola) for time periods ranging from 1 day to 1 year. In neutral media, the compressive and biaxial flexural strengths of all cements studied showed similar results, with significant increases apparent in compressive strengths at 6 months and which continued to 1 year, but no significant differences between the media; and no significant differences with time for biaxial flexure strength in all media. These findings show that interactions of these cements with saliva, which are known to result in deposition of calcium and phosphate, do not affect strength. Results for specimens stored in Coca-Cola were the same as for those stored in neutral media. By contrast, in orange and apple juice specimens underwent severe erosion resulting in dissolution of the conventional glass-ionomers after 3-6 months, and/or significant loss of strength at 1-3 months. Erosion of the resin-modified glass-ionomer, Vitremer, led to a significant reduction in strength, but not in dissolution, even after 12 months. The chelating carboxylic acids in these fruit juices were assumed to be responsible for these effects.

Beverages↗
PubMed2003

Effect of molecular weight and concentration of poly(acrylic acid) on the formation of a polymeric calcium phosphate cement.

Previous investigations have noted that the tetracalcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA) apatite forming calcium phosphate cement (CPC) possesses many favorable properties from a biomaterials standpoint. Despite these positive properties various shortcomings have limited clinical usage of these materials and fostered investigations into the effect of numerous additives. The present study concerns the effect of poly(acrylic acid) (PAA) addition and the influence of factors such as molecular weight and concentration of the additive on the properties of the set cement. One-way ANOVA was conducted using all results obtained, to firstly derive the influence of concentration within each molecular weight group, and secondly to derive the influence of molecular weight within each concentration group. All investigated mechanical properties were influenced by both molecular weight and concentration of the additive. Higher molecular weights tended to result in cements with shorter setting times and higher compressive, diametral and biaxial flexural strengths than their lower molecular weight counterparts. The effect of concentration on the properties of the set cement however was somewhat more complex, a negative correlation was observed between the initial setting time and PAA concentration. In regards to the final setting time, any correlation with concentration was difficult to derive as a consequence of the highly brittle nature of cements made with low concentrations. In regard to mechanical properties, intermediate concentrations tended to give higher strengths than both their higher and lower counterparts, however the exact pattern was largely specific to the mechanical strength test employed. We conclude that molecular weight and concentration of PAA influence the setting behavior and final mechanical properties of the TTCP/DCPA cement, and that selection of an appropriate PAA solution can lead to the production of cements with properties superior to those formed in the absence of the polymer.

Journal Article↗
PubMed2003

The effect of saliva on surface hardness and water sorption of glass-ionomers and "compomers".

A study is reported in which commercial dental materials (glass-ionomers, resin-modified glass-ionomer and polyacid-modified composite resins) in the form of discs of dimensions 6 mm diameter x 1 mm thickness were prepared and exposed to natural salivas (parotid and unstimulated whole), artificial saliva and water for up to 1 year. Surface hardness was measured at various time intervals, and water sorption characteristics were determined. For all types of material, storage in artificial saliva gave specimens of lowest surface hardness by amounts that were generally significant to p<0.05, whereas no differences were found between specimens stored in water or either of the natural salivas. Water sorption characteristics were found to be unaffected by the nature of the storage medium. These results contrast with some previous findings and were not expected, given the known surface reactions between salivas and glass-ionomers, or the known enzymic degradation of composite resins. They demonstrate, however, that the current widespread practise of employing pure water for storage of specimens in laboratory studies is acceptable.

Journal Article↗