PubMed Health⌕ Search

Biomedical subjects

J W Potter

Publications and source records attributed to J W Potter.

At least 55 records · Page 3Linked to original sources
PubMed1985

Location and characteristics of the prepapillary annular opacity.

Of 100 patients with a prepapillary annular opacity in age-related posterior vitreous detachment with collapse, 44 had floater symptoms corresponding to their opacity. Ninety-two of the patients had a prepapillary annular opacity in only one eye. Two-thirds of the opacities could be observed within plus or minus one diopter of four diopters into the posterior chamber, and all of the opacities could be observed within a two to seven diopter range. Approximately one-third of all the prepapillary annular opacities were complete rings.

Diagnosis, Differential↗
PubMed1985

Peripapillary hemorrhages in acute posterior vitreous detachment.

Posterior vitreous detachment is an important clinical finding. In addition to producing a variety of visual symptoms, it can also precipitate retinal and vitreous hemorrhages, edema of the optic disc and macula, and retinal breaks. We document the occurrence of peripapillary hemorrhages following acute posterior vitreous detachment.

Eye Diseases↗
PubMed1984

The clinical significance of the vortex veins.

The vortex veins are significant ophthalmoscopic landmarks in the peripheral fundus. Their position provides a consistent vantage point for the clinician to use for orientation in performing binocular indirect ophthalmoscopy. Rarely, vortex veins may be affected by disease.

Choroid↗
PubMed1984

Vision symptoms with asteroid bodies in the vitreous.

Asteroid bodies in the vitreous present the doctor of optometry with a spectacular ophthalmoscopic view of numerous, minute yellow-white spheres in an otherwise normal vitreous. They have little or no association with systemic disease, and they are not often thought of as a cause for vision symptoms. We report four cases of vision symptoms that we believe were caused by asteroid bodies in the vitreous. The symptoms varied from minor impairments in visual acuity to floaters.

Aged↗
PubMed1983

Production of a human T lymphocyte chemotactic factor by T cell subpopulations.

Concanavalin A-stimulated human peripheral blood mononuclear cells release a lymphocyte chemotactic factor. This lymphocyte chemotactic factor is produced optimally after 24 to 48 hr of culture and is not found before 3 hr of culture, which suggests that the factor is synthesized de novo and is not preformed and secreted after Con A stimulation. This is further supported by experiments showing that the protein synthesis inhibitors cycloheximide and puromycin totally prevent the production of the chemotactic factor. Experiments using cultured and uncultured T lymphocytes as responding cells show that cultured T cells respond more efficiently than uncultured T cells to this factor. Furthermore, the lymphocyte chemotactic factor preferentially stimulates T lymphocyte locomotion as compared to peripheral blood non-T lymphocyte migration. Fractionation of mononuclear cells into glass nonadherent lymphocytes, monocyte-enriched preparations, T lymphocytes, and non-T lymphocytes shows that lymphocyte chemotactic factor is produced by Con A-stimulated, glass nonadherent lymphocytes and T cells but not by monocytes or non-T lymphocytes. Further fractionation of T lymphocytes into Leu-2 and Leu-3 T cell subpopulations shows that the production of T lymphocyte chemotactic factor can be attributed to the Leu-2 suppressor/cytotoxic T cell subset. The generation of a T lymphocyte chemotactic factor by Leu-2 T cells may represent a means of recruiting other T cells to the site of its release.

Chemokines, C↗
PubMed1983

Migration of human helper/inducer T cells in response to supernatants from Con A-stimulated suppressor/cytotoxic T cells.

Previous studies have shown that supernatants from Con A-stimulated human mononuclear cells are chemotactic for T cells, and that the source of the activity is the Leu-2 (suppressor/cytotoxic) T cell. The specificity of this chemoattractant activity for Leu-2 and/or Leu-3 (helper/inducer) T cells was analyzed with isolated human T cell subsets in an in vitro chemotaxis assay system. These studies demonstrate that both human Leu-2 and Leu-3 cells migrate in response to the lymphocyte locomotor stimulus casein, whereas only Leu-3 cells migrate in response to supernatants from Con A-stimulated mononuclear cells. This migration of Leu-3 cells to the Con A supernatant was reflected in both the distance migrated and the number of migrating cells. When Leu-2 cell locomotion in response to Con A supernatants was analyzed, no significant differences from control were observed in either the distance migrated or the number of migrating cells. Supernatants from Con A-stimulated Leu-2 cells similarly attracted Leu-3 cells but not Leu-2 cells in a concentration-dependent manner. Supernatants from Con A-stimulated Leu-3 cells did not stimulate either Leu-2 or Leu-3 cell migration. These studies demonstrate that Leu-3 T cells migrate in response to supernatants from Con A-stimulated Leu-2 T cells. This specific response may promote cell-to-cell interaction by providing a means for Leu-2 T cells to recruit Leu-3 T cells.

Chemotactic Factors↗
PubMed1983

The blue field entoptic test with normal patients.

One hundred normal patients were evaluated with the Blue Field Entoptoscope test. Of those one hundred patients, ninety-nine were able to describe the appearance of their own leukocytes. The methodology did not permit encouraging or coaching patients to see their leukocytes. Of the ninety-nine who could perceive their own leukocytes, nineteen 19.19%) were unable to perceive an approximately equal number in each of the four quadrants of the blue field of light which is divided by a reticle. These patients who did not see an equal number of leukocytes in all four quadrants were generally older than those who saw an equal number of leukocytes. The results indicate that if the Blue Field Entoptoscope is to be used in clinical practice or research, it is useful to standardize the instrument for the population studied. In particular, the instrument should be standardized for age.

Adolescent↗
PubMed1982

Differential Protein Composition and Gene Expression in Leaf Mesophyll Cells and Bundle Sheath Cells of the C(4) Plant Digitaria sanguinalis (L.) Scop.

The distribution and molecular weights of cellular proteins in soluble and membrane-associated locations were analyzed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Coomassie blue staining of leaf (Digitaria sanguinalis L. Scop.) extracts and isolated cell extracts. Leaf polypeptides also were pulse-labeled, followed by isolation of the labeled leaf cell types and analysis of the newly synthesized polypeptides in each cell type by electrophoresis and fluorography.Comparison of the electrophoretic patterns of crabgrass whole leaf polypeptides with isolated cell-type polypeptides indicated a difference in protein distribution patterns for the two cell types. The mesophyll cells exhibited a greater allocation of total cellular protein into membrane-associated proteins relative to soluble proteins. In contrast, the bundle sheath cells exhibited a higher percentage of total cellular protein in soluble proteins. Phosphoenolpyruvate carboxylase was the major soluble protein in the mesophyll cell and ribulose bisphosphate carboxylase was the major soluble protein in the bundle sheath cell. The majority of in vivo(35)S-pulse-labeled proteins synthesized by the two crabgrass cell types corresponded in molecular weight to the proteins present in the cell types which were detected by conventional staining techniques. The bundle sheath cell and mesophyll cell fluorograph profiles each had 15 major (35)S-labeled proteins. The major incorporation of (35)S by bundle sheath cells was into products which co-electrophoresed with the large and small subunits of ribulose bisphosphate carboxylase. In contrast, a major (35)S-labeled product in mesophyll cell extracts co-electrophoresed with the subunit of phosphoenolpyruvate carboxylase. Both cell types exhibited equivalent in vivo labeling of a polypeptide with one- and two-dimensional electrophoretic behavior similar to the major apoprotein of the light-harvesting chlorophyll a/b protein. Results from the use of protein synthesis inhibitors during pulse-labeling experiments indicated intercellular differences in both organelle and cytoplasmic protein synthesis. A majority of the (35)S incorporation by crabgrass mesophyll cell 70S ribosomes was associated with a pair of membrane-associated polypeptides of molecular weight 32,000 and 34,500; a comparison of fluorograph and stained gel profiles suggests these products resemble the precursor and mature forms of the maize chloroplast 32,000 dalton protein reported by Grebanier et al. (1978 J. Cell Biol. 28:734-746). In contrast, crabgrass bundle sheath cell organelle translation was directed predominantly into a product which co-electrophoresed with the large subunit of ribulose bisphosphate carboxylase.

Journal Article↗
PubMed1982

Vascular anastomoses in ocular toxoplasmosis.

Toxoplasmosis is a frequent cause of uveitis seen in clinical practice and fundus scars typical of ocular toxoplasmosis are common. It has been reported that vascular anastomoses between the retinal and choroidal circulation can occur through the damaged Bruch's membrane in fundus scars resulting from ocular toxoplasmosis. Although it has been stated that these vascular anastomoses are a rare occurrence, it has also been suggested that they are relatively common. In order to determine the prevalence rate of patients with vascular anastomoses in toxoplasmic fundus scars, 3,850 consecutive optometry patient files were studied retrospectively. Seventy-four patients (1.92%) had a clinical diagnosis of ocular toxoplasmosis with typical fundus scars, and two of these patients (2.70%) had documented vascular anastomoses.

Chorioretinitis↗
PubMed1981

Clinical investigation of the foveal light reflex.

Over a 2-month period, 1,516 optometric patients were evaluated by a collaborative study group of 30 staff doctors in Veterans Administration Medical Centers and Outpatient Clinics. The purpose of the evaluation was to determine the status of foveal light reflexes in the population, and thereby to establish normative data for this clinical phenomenon. Frequency data, correlation analyses, and literature citations are included in the paper.

Adult↗
PubMed1981

Goldmann applanation tonometry without fluorescein.

Recently, there have been several suggestions that Goldmann applanation tonometry can be performed without fluorescein. In order to determine the clinical efficacy of performing Goldmann applanation tonometry without fluorescein, 100 consecutive patients had applanation tonometry performed without fluorescein (Ophthetic only) and with fluorescein (Fluress), according to a predetermined randomization schedule. It was found that the average difference between readings with fluorescein and without fluorescein was 7.01 mm Hg. Tonometry readings without fluorescein were lower than readings with fluorescein. In addition, regression analysis indicated that the differences between the readings with and without fluorescein increased as intraocular pressure increased. By not utilizing fluorescein in Goldmann applanation tonometry, the clinician will record lower readings. In addition, greater errors in measurement occur with increasing intraocular pressures. Because eyes with higher intraocular pressures are at a greater risk to develop glaucomatous optic atrophy and loss of visual field, the merits of Goldmann applanation tonometry without fluorescein are speculative.

Fluoresceins↗
PubMed1981

Part II. Diagnostic outcomes of optometric referrals in a VA medical center.

In a previous study, the authors examined the medical records of patients seen in the optometry clinic of the Birmingham Veterans Administration Medical Center (BVAMC) who were referred to other providers within the BVAMC for diagnosis and/or treatment of health problems outside the scope of optometric clinical privileges. The present study examined an equivalent number of medical records of patients who had been examined in the optometry clinic but were not referred to other health care providers within the BVAMC. By utilizing retrospective clinical judgment, the authors found that 3 of 266 patients (1.13 degrees) that were not referred probably should have been. None of the 3 patients had potentially sight or life threatening disorders. An algorithm for the methodology and case reports of the 3 patients are presented.

Eye Diseases↗
PubMed1981

Geographic atrophy of the retinal pigment epithelium: diagnosis and vision rehabilitation.

Senile macular disease has been found to be a common cause of legal blindness and visual impairment. The spectrum of clinical manifestations can present many variations of exudative and non-exudative disease. Three cases of one manifestation, geographic atrophy of the retinal pigment epithelium, are described with emphasis on differential diagnosis from a clinically similar disease, central areolar choroidal dystrophy. It has been reported that patients with central areolar choroidal dystrophy do not respond well to magnification. We found that patients with geographic atrophy of the retinal pigment respond well to magnification and vision rehabilitation.

Aged↗
PubMed1980

Pigmented paravenous retinochoroidal atrophy.

Pigmented paravenous retinochoroidal atrophy is an uncommon fundus disorder with a striking clinical presentation. It is characterized by the bilateral symmetrical appearance of posterior pole abnormalities including granular pigment cuffs around the larger retinal veins and their bifurcations and variable degrees of retinochoroidal atrophy about the affected veins and the optic disc. The maculas are spared of clinically observable abnormalities, and the vast majority of patients with this disorder are asymptomatic. Most of the approximately four dozen cases previously reported in the scientific literature have been discovered during routine ophthalmoscopy. The visual prognosis for patients with pigmented paravenous retinochoroidal atrophy is quite good. Two cases of this disorder are presented in order to draw attention to the clinical characteristics and the management of patients with a diagnosis of pigmented paravenous retinochoroidal atrophy.

Adult↗
PubMed1980

Prevalence of asteroid bodies in a VA optometry clinic.

One thousand, five hundred and fifty-nine consecutive optometry clinic records at the Birmingham Veterans Center (BVAMC) were reviewed in an attempt to determine the prevalence of asteroid bodies in the vitreous. A review of the pertinent literature was conducted and a higher prevalence was found in our population than that reported in the literature. The difference was statistically significant at the 0.05 level.

Adolescent↗
PubMed1979

Diagnostic outcomes of optometric referrals in a VA medical center.

408 conditions affecting the visual system of patients presenting in the optometry clinic of the Birmingham Veterans Administration Medical Center (BVAMC) were referred to other providers within the medical center for care outside the scope of optometric responsibility. Rates of compliance and confirmation are given for nine major categories of eye problems, and the data is analyzed on the basis of age, visual acuity, type of consultation and disposition. Pertinent literature citations are provided.

Alabama↗