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J W Rohrer

Publications and source records attributed to J W Rohrer.

7 recordsLinked to original sources
PubMed1979

Immunoregulation of localized and disseminated murine myeloma: antigen-specific regulation of MOPC-315 stem cell proliferation and secretory cell differentiation.

Tumor development, MOPC-315 stem cells, and M315-secretory cells were quantitated in carrier-primed BALB/c mice that had been challenged subcutaneously or i.v. with mixtures of TNP-carrier and TNP-binding MOPC-315 cells. We observed that tumor incidence, myeloma stem cells, and secretory myeloma cells were: i) suppressed in mice in whom carrier-specific suppressor T cells had previously been induced and ii) initially ehnahced in mice with carrier-specific helper T cells. The early enhancement in mice with carrier-specific helper T cells was followed by progressively declining myeloma stem cell frequencies and regression of established tumors. These studies demonstrate that T cell-derived immunoregulators of host origin can be focused onto localized and disseminated malignant B cells and specifically regulate the expansion and differentiation of the neoplastic clone.

Animals↗
PubMed1978

Antigen-specific regulation of myeloma cell differentiation in vivo by carrier-specific T cell factors and macrophages.

Previous studies demonstrated that: i) the TNP-binding myeloma MOPC-315 differentiated during in vivo growth in diffusion chambers (DC) implanted i.p. into normal BALB/c mice, and ii) the myeloma cell differentiation was regulatable by carrier-specific presentation of TNP to MOPC-315 cells in carrier-primed mice. In those studies, promotion and suppression of MOPC-315 differentiation occurred in the presence of carrier-specific helper and suppressor activities, respectively. In the present studies, we demonstrate that carrier-specific regulation of MOPC-315 differentiation can be adoptively transferred to normal mice with carrier-primed T lymphocytes. In addition, the induced regulation of MOPC-315 differentiation is abrogated when macrophages are not present with MOPC-315 cells in the DC. These studies establish the immunologic basis of myeloma cell regulation and suggest that soluble, carrier-specific helper and suppressor factors of T cell origin regulate MOPC-315 differentiation directly or in collaboration with macrophages.

Animals↗