PubMed Health⌕ Search

Biomedical subjects

J W Rosenthal

Publications and source records attributed to J W Rosenthal.

8 recordsLinked to original sources
PubMed1983

Histopathology of corneal leukoma and fibroma in the ACL syndrome.

Corneal tissues of four persons and a buccal fibroma from one of these persons with ACL syndrome, an autosomal dominant disorder, were evaluated clinically and microscopically. The corneal lesions appeared as a gray epithelial infiltrate over the cornea, destroying Bowman's membrane. Light and electron microscopic images of both types of lesions showed abnormal accumulation of granular mucopolysaccharide material and extensive aberrant orientation of collagen fibers. The authors postulate that the mucopolysaccharide accumulation is involved in the pathogenesis of the syndrome.

Acromegaly↗
PubMed1975

The effect of insulin on basal and hormone-induced elevations of cyclic AMP content in cultured human fibroblasts.

Studies were carried out on confluent cultures of human fibroblasts to explore the effect of insulin on basal and hormone-induced elevations of intracellular cyclic AMP content during short-term incubations in serum-free medium. Insulin tended to decrease basal levels of cyclic AMP but this was not statistically significant. Similarly, insulin was unable to block the elevations of intracellular cyclic AMP content induced by PGE1, epinephrine and glucagon. Paradoxically, when cells were preincubated with insulin, PGE1-stimulated cyclic AMP elevation was potentiated, possibly because insulin was conserving factors needed for a maximal PGE1 stimulus or retarding the leakage of cAMP itself. The results indicate that insulin has little or no direct effect on cyclic AMP metabolism in cultured human fibroblasts and is consistent with the known insensitivity of these cells to insulin for other parameters.

Adult↗