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Biomedical subjects

J W THOMAS

Publications and source records attributed to J W THOMAS.

At least 19 recordsLinked to original sources
PubMed1964

HEMOLYTIC TRANSFUSION REACTIONS.

After receiving apparently compatible blood three patients suffered hemolytic reactions. The compatibility tests were by saline and indirect Coombs technique including a screening tube of group 0 cells. The antibodies responsible for these reactions were not clearly demonstrable for several days following the transfusion. In two instances the antibody was anti-E.These case reports point up the following. (a) Currently used cross-matching procedures will occasionally fail to demonstrate an incompatibility. (b) In two of the cases the direct Coombs test was negative on an immediate post-transfusion specimen, when it could have been of great aid in diagnosis. (c) When a transfusion reaction of hemolytic type is suspected, a follow-up study several days after the reaction may clarify the diagnosis; when possible, transfusions should be avoided in the interim.

Antibodies↗
PubMed1963

Free and total vitamin B12 in cerebrospinal fluid.

Free and total vitamin B(12) levels in serum and cerebrospinal fluid (CSF) were bioassayed, since there were no available data on the relationship between free and total vitamin B(12) in CSF or between free vitamin in serum and CSF vitamin B(12). The subjects were 43 neurological patients. Serum levels were normal in 40 of 43 patients. Values for free and total vitamin B(12) in CSF were the same in 42 of 43 patients. Mean CSF vitamin B(12) was 21 mumug./ml. In 17 cases CSF vitamin B(12) equalled free vitamin B(12) level in serum, in 16 cases CSF vitamin B(12) was lower than the free level in serum, and in 10 cases CSF vitamin B(12) was higher than the free vitamin level in serum. There was no apparent diagnostic correlation. The findings suggest that vitamin B(12) is not bound in CSF and that there is some selective control of passage of vitamin B(12) across the blood-CSF barrier.

Biological Assay↗
PubMed1963

Congenital hypofibrinogenemia in five members of a family.

The bleeding tendency in five members of one family with fibrinogen levels ranging from 58 mg. % to 158 mg. % was mild and chiefly related to dental extractions. Abruptio placentae in one patient produced severe bleeding. Reports of menstrual bleeding patterns in patients with defects of hemostatic mechanisms suggest that normal platelets, vascular function and extrinsic and possibly intrinsic coagulation systems, except for fibrinogen, control menstrual blood loss. An autosomal dominant gene with variable penetrance may determine fibrinogen levels.

Abruptio Placentae↗