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Biomedical subjects

J W Yarbro

Publications and source records attributed to J W Yarbro.

At least 55 records · Page 3Linked to original sources
PubMed1986

Tumors of unknown origin in the bone marrow.

Tumors of unknown origin represent a common presentation of malignancy. However, tumors of unknown origin presenting as bone marrow metastases are infrequently reported. The records of 11,820 bone marrow biopsy procedures over a 15-year period at a university hospital and a veteran's hospital were reviewed, disclosing 25 cases of tumor of unknown primary site. Most of the patients were elderly and presented with bone pain or abdominal pain. Anemia, thrombocytopenia, and a leukoerythroblastic blood picture were common hematologic findings. Examination for detection of the primary site was usually unrewarding. The median survival of patients was very short (18 days) and therapy seldom altered survival.

Adenocarcinoma↗
PubMed1978

Effects of 1,10-phenanthroline and a zinc complex of 1,10-phenanthroline on nucleic acid synthesis in mouse liver and spleen.

The effects of 1,10-phenanthroline and a zinc complex of 1,10-phenanthroline on nucleic acid synthesis were examined by noting the capcity of these agents to incorporate [methyl-3H]thymidine, or [5-3H]uridine into hepatic and splenic DNA and RNA. Within 32 hours after the intraperitoneal injection of 1,10-phenanthroline in mice, a decrease of [methyl-3H]thymidine incorporation into hepatic DNA was observed. The administration of the zinc complex of 1,10-phenanthroline decreased the incorporation of [5-3H] uridine into hepatic RNA within 24 hours and decreased the formation of [3H]DNA from [methyl-3H]thymidine in the liver within 24 and 32 hours. An increase of the isotopic incorporation into hepatic RNA and of the pool size of ATP within 2 hours after the administration of the complex was also noted. In the splenic studies, the zinc complex significantly inhibited the formation of labeled DNA and RNA at 2, 8, 24, and 32 and 2, 8 and 24 hours postinjection, respectively. A relationship exists between the results obtained from sequential treatment (zinc chloride after 1,10-phenanthroline) and those derived from the zinc complex of 1,10-phenanthroline pertaining to an inhibition of isotopic incorporation into hepatic and splenic nucleic acid.

Adenine Nucleotides↗
PubMed1976

Intralesional BCG in the treatment of metastatic malignant melanoma.

The therapeutic efficacy of intralesional BCG (Bacillus Calmette-Guerin; one immunizing dose every 2 weeks for a minimum of five treatments) was studied in 19 melanoma patients. Of 15 patients evaluable for response, five experienced significant objective improvement (two complete and three partial remissions). Objective improvement was limited to those patients with dermal metastatic disease. In vitro cytotoxicity in the presence of patient's serum bore, on average, a relationship to the clinical disease. In certain individual cases, serum blocking and/or lymphocyte stimulation may have had prognostic significance.

Adolescent↗
PubMed1976

Cancer centers: their relationship to the academic community.

During the past decade one important change that has occurred in medical education has been the development of multidisciplinary research, education, and treatment efforts by new groups of scholars drawn from multiple disciplines. In their daily activities members of such groups have more in common with their new affinity group than with their traditional discipline. Yet important adminstrative functions such as appointment, assignment of space, and allocation of budget are conducted by separate administrative units. This has produced stress and conflict within many academic institutions. Some of the lessons learned by institutions participating in the cancer center program may be generally applicable. Comprehensive cancer centers have evolved several types of administrative sturctures, but there is a common characteristics among the most successful. Each has developed some modification of a matrix system with delegation of significant administrative authority to the center. If the matrix approach is successful in cancer, it may become a pattern for other programs in the future.

Forecasting↗