Biomedical subjects

J Wågermark

Publications and source records attributed to J Wågermark.

16 recordsLinked to original sources

PubMed1993

Very late mucosal relapse in a girl with coeliac disease.

Small bowel biopsy in a 4-year-old girl with symptoms suggestive of coeliac disease revealed subtotal villous atrophy. The mucosa healed on a gluten-free diet. From the age of 7 years, the girl was challenged with gluten. Annual biopsies showed normal or nearly normal mucosa specimens. At 21 years of age, after 14 years of gluten challenge, a mucosal relapse was found and a gluten-free diet was reinstituted. A biopsy one year later showed a normal mucosa. From this case report it is apparent that a patient with a past history of subtotal villous atrophy, which after a preceding period of gluten-free diet does not recur within two years of gluten challenge, must be followed carefully, so as not to miss a late relapse.

Adult↗

PubMed1983

Colorectal endometriosis.

Endometriosis is a common disease occurring in about 10% of all women. Involvement of the gastrointestinal tract is not infrequent and endometriosis should therefore be considered in the differential diagnosis of colon lesions in women of childbearing and middle age. Colorectal endometriosis may cause obstructing symptoms difficult to distinguish from malignant or inflammatory disease, as is demonstrated by 6 case reports. Colorectal endometriosis is mostly localized to the sigmoid or the anterior rectal wall with extramucosal radiologic appearance and is difficult to diagnose by sigmoidoscopy. Patients with an infiltration of the anterior rectal wall (shelf tumour) should undergo a complete evaluation including laparoscopy before surgery is considered. Bowel resection often offers the best chance of cure.

Adult↗

PubMed1982

A family study of coeliac disease.

Small intestinal biopsy was performed in all 100 first-degree relatives of 32 index patients with childhood coeliac disease (CD) diagnosed according to the European Society for Paediatric Gastroenterology and Nutrition. CD was found in 2 relatives (2.0%), which means that first-degree relatives of coeliac children would run a ten-fold increased risk of CD compared with the general population of Sweden. Five relatives had a moderately abnormal mucosa. On rebiopsy they had a normal mucosa and are therefore not classified as having CD according to current diagnostic criteria. For practical purposes it would be impossible to perform a biopsy in all first-degree relatives of coeliac patients. However, relatives with a past history of symptoms suggestive of malabsorption and relatives with present signs of malabsorption should be candidates for biopsy.

Adolescent↗

PubMed1980

Familial clustering of malignant mesothelioma.

A family with a remarkable aggregation of malignant mesothelioma is described. The father, 3 brothers, and a sister all died of the condition. The family and epidemiologic histories are reviewed. Random occupational asbestos exposure in the building industry probably occurred in 4 of the 5 cases. All of the patients were smokers. There is a low incidence of malignant mesothelioma in the area where they resided. These observations suggest that over and above the smoking and asbestos exposure, heredity may be an important predisposing factor in the genesis of this tumor.

Asbestos↗

PubMed1970