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Biomedical subjects

J Waśkiewicz

Publications and source records attributed to J Waśkiewicz.

At least 37 records · Page 2Linked to original sources
PubMed1987

Is neurotransmitter histamine predominantly inactivated in astrocytes?

Rat synaptosomes and astroglia cell-enriched fraction were tested for the uptake of histamine (HA) and its precursor histidine, and the activities of the HA-synthesizing enzyme, histidine decarboxylase (HD) and HA-metabolizing enzyme, histamine methyltransferase (HMT). While histidine uptake was more active into synaptosomes than into astrocytes, only astrocytes were capable of a significant HA uptake. Kinetic analysis of the astrocytic HA uptake revealed a high affinity-low capacity system (Km = 5 X 10(-7) M, Vmax = 1.6 X 10(-12) mol.min-1 X mg-1) similar to the astroglial transport systems for other neurotransmitters. HMT was 70% more active in astrocytes than in synaptosomes, whereas HD activity was not different in these two preparations. The results indicate that astrocytes could be the major site of neurotransmitter HA inactivation.

Animals↗
PubMed1985

Changes in electrocardiograms at rest among dockers employed at loading/discharging of dusty materials.

Examinations were carried out among 602 dockers of sea-ports working at stevedore and trimmer work places in loading/discharging of dusty materials. The mean age of the population examined was 40.38 SD+/- 8.83 years and the mean length of service 13.33 SD +/- 6.91 years. In the material examined the authors found 32.7 per cent of cases with chronic non-specific respiratory system diseases. The evaluation of electrocardiograms was performed with the use of Minnesota code. We have found abnormal electrocardiograms in 49.16 per cent of the persons examined, but in 119 persons were observed patterns of the influence of parasympathetic system, which one should recognize as features of good training and fitness to perform hard physical work. If this just mentioned group is left out the total of the abnormal electrocardiograms reaches 28.90 per cent. In ECG recordings we have found pathologic changes in Q and QS waves evidencing the existence of necrotic foci and healed infarct. In cases of chronic non-specific respiratory system diseases (37.7 per cent) occurring particularly over age of 50 years P-pulmonale waves, complete and incomplete right bundle branch blocks, jagged QRS complex and rotation change, as traits of right ventricular hypertrophy were found.

Adult↗
PubMed1983

Evaluation of the state of the circulatory system in the officers of the Polish Ocean Lines. III. A physical analysis of circulation.

The results of the physical analysis of circulation presented in this report are a further fragment of our research on the state of the circulatory system in the merchant marine officers over 40. 307 men were selected at random for the examinations, this constituting 13.5 per cent of the total population of the officers employed by the shipowner. Altogether the examinations covered 118 deck officers, 152 engine-room officers and 37 officers of the catering department. The parameters of the physical analysis of circulation were calculated according to Broemser-Ranke. The mean value of pulse wave velocity at the aorta was 833.63 +/- 155.41 cm/sec and in the radial artery--891.93 +/- 124.91 cm/sec for the whole examined population. The mean deformation resistance for all the examined was 1349.02 +/- 248.68 dyne/cm and the circumferential resistance--1347.55 +/- 347.89 sec. dyne/cm3. The mean systolic discharge for all the examined was 82.68 +/- 18.66 ml and the minute stroke volume 6.64 +/- 1.92 l/min. The mean work of the heart 1.20 +/- 0.38 J, the heart's power--1.60 +/- 0.59 W. The velocity of the discharge from the left ventricle was on average 17.66 +/- 3.44 l/min. For those parameters no statistically significant differences were found between particular groups of employment aboard. However, statistically significant differences were discovered in the calculations of the pulse wave velocity at the aorta. The differences were noticed between the group of clinically healthy men (771.52 +/- 114.71 cm/sec) on the one hand and the overweight group (854.39 +/- 116.34 cm/sec), the obese group (900.13 +/- 155.08 cm/sec), the group with ECG changes (925.01 +/- 193.24 cm/sec), the group with systolic and diastolic hypertension (acc to WHO criteria) (997.16 +/- 177.82 cm/sec), and in the group with hypertension accompanied by systolic discharge murmurs above the aorta (1113.38 +/- 127.24 cm/sec)--on the other. The pathological pulse wave velocity in the aorta (i.e. velocity of at least 9 m/sec) was found in 22.47% of the whole examined population.

Adult↗