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Biomedical subjects

J Warter

Publications and source records attributed to J Warter.

At least 19 recordsLinked to original sources
PubMed1991

[Anacollagenase by the action of amitriptyline on Clostridium histolyticum collagenase].

Intraperitoneal injection of a mixture of collagenase (300 U) and amitriptyline (Laroxyl*, 3 mg) induce no lesions in contrast with the severe effects of collagenase alone. Also, a complete resistance to intraperitoneal collagenase injection is observed when preceded by 3 intramuscular injections of the same mixture (associated with Freund's incomplete adjuvant). This is due to the development of collagenase antibodies, as demonstrated by nephelometry and immunodiffusion. These facts show that amitriptyline neutralizes the enzymatic properties of collagenase, without alterring its antigenicity. We propose to call this new substance anacollagenase. Such a phenomenon has never been observed with a drug. However we got identical results with other tricyclic depressants (clomipramine, imipramine, doxepine, iprindole). The mechanism of the transformation of collagenase into anacollagenase is not yet explained.

Amitriptyline↗
PubMed1987

[Inhibitory action of methysergide bimaleate on the collagenase of Clostridium histolyticum].

Inhibitory effects of methysergide bimaleate on the collagenase of the Clostridium histolyticum have been established. Having previously shown the inhibitory action of serotonin on this bacterial collagenase, the authors have tested methysergide bimaleate as another inhibitor. After injection in the peritoneum of the rats of methysergide bimaleate and collagenase together, lesions are minimal or absent, in contrast with the dramatic effects of collagenase alone. This shows the antagonist role of methysergide bimaleate in regard to collagenase and suggest that methysergide bimaleate reduce the collagenolysis and may elucidate the possible occurrence of fibrotic lesions after treatment of migraine by methysergide bimaleate in man.

Animals↗
PubMed1982

[Gastrostomy lasting 59 years].

We report on an unusual observation of a woman who lived with a gastrostomy for fifty-nine years. Gastrostomy was performed at age twenty-six after esophageal burn. The patient died at age eighty-five. Digestive functions were normal. Calorie intake was below normal requirements. Diet was monotonous and unbalanced with protein deficiency. However, body weight and plasma protein levels were normal. Psychological and gustative behaviours are discussed.

Adult↗
PubMed1982

[Probable inhibition of a bacterial collagenase by serotonin].

We have previously demonstrated that intraperitoneal injections in rats of collagenase (from Clostridium histolyticum) are followed by severe lesions. Here we show that the injection of collagenase together with serotonin has no or only small effects. It appears to be partly due to serotonin. Creatinin and sulfate which form an injectable complex with serotonin have no influence on this phenomenon. The part of pH 4,4 of the injected solution is discussed. These facts suggest that serotonin may perhaps lower the collagenolysis and be thus responsible for the fibrogenetic effects of carcinoid tumors, many of these being characterised by their high production of serotonin.

Animals↗
PubMed1981

[Insensitivity of some rats to intraperitoneal injections of collagenase and trypsin].

In the rat peritoneal injections of collagenase or trypsin give rise to severe lesions. In our experience 20% of the animals remain intact. The frequency of lesions increases with older and heavier subjects. Moreover 25% of the rats who remained free of lesions after a first injection of collagenase resist to a second one. This shows that they are strongly protected against the enzyme. The exact nature and location of this protective mechanism are not known.

Animals↗
PubMed1979

[Real-time cross-sectional echocardiography. Application in the measurement of the surface area of the mitral orifice in cases of stenosis or of double involvement of the valve (author's transl)].

Two-dimensional echocardiography in real time has proved in recent years to be a very valuable means of investigation in cardiology, in particular in the area of valve disease and congenital cardiac malformations. The present study concerns a group of 20 patients with essentially stenosing mitral disease, studied by two-dimensional echocardiography using mechanical sector scanner. The authors report their experience of the method in the measurement of the surface area of the mitral orifice from echotomographic sections obtained in protodiastole in a plane perpendicular to the long axis of the left ventricle and passing through the free edge of the mitral cusps. Fifteen of these patients being then treated by valve replacement, the area measured were compared with those found in the operative specimens. In 14 cases out of 15 (93%), despite the concomitant existence of appreciable mitral incompetence in 9 cases out of 15, the surface areas did not differ by more than 0.23 cm2 (coefficient of correlation = 0.990). These results confirmed that two-dimensional echocardiography in real time is a reliable method for the direct measurement of the mitral orifice area in the presence of stenotic type disease of the valve and even in the presence of associated mitral regurgitation.

Adult↗
PubMed1979

[Corticosteroid-sensitive chemical diabetes in Horton's disease].

We report 5 cases of temporal arteritis associated with a diabetes whose good evolution under corticotherapy suggests a common pathogenesis. Several hypotheses can be formulated to explain the origin of the glycemic abnormality and to understand the way corticotherapy is effective. A moderate posology could at first have a hyperplasic effect on the insulin-secreting cells, and later on a favorable action on the vascular lesion and on an immunological disorder. Any definitive conclusion cannot be evolved yet. Only a more systematical study of the glycoregulation's abnormalities in the temporal arteritis will enable to answer the many remaining questions.

Adrenal Cortex Hormones↗
PubMed1979

[Malabsorption syndrome during the initial phase of a case of severe rheumatoid purpura].

We report a case of severe Henoch syndrome in which the first manifestation was digestive with a prolonged and important intestinal malabsorption syndrome. The clinical, radiological and histological data allow to consider a malabsorption due to lesions of the chorion and submucosa probably secondary to the allergic vasculitis. The malabsorption syndrome, confirmed by the intestinal absorption tests, the study of which must be more systematic, seems to belong to the severe and polyvisceral forms of the Schönlein-Henoch syndrome.

Abdomen, Acute↗
PubMed1979

[Grawitz's tumor and provoked hyperlipemia (author's transl)].

After reporting a case of a patient aged 69 years with an inoperable hypernephroma, in whom the presence of a polycythemia and a reduction in the provoked hyperlipemia curve was found to co-exist, the authors review the data in the published literature on the influence on the small intestine of cancers other than those in the gastro-intestinal system. Basing their comments on studies of hypernephromas, they stress that a reduction or delay in the hyperlipemia curve was found in 23 out of 28 patients. This abnormality can only be explained by hypotheses at the present time.

Adenocarcinoma↗
PubMed1978

[Real-time cross-sectional echocardiography using a mechanical sector scanner (author's transl)].

Ultrasonic one-dimensional echocardiography have proven extremely useful these last years in cardiac diagnosis. However, it allows only, structures lying along a narrow ultrasonic beam, to be visualized. In order to state more precisely the spatial relationship of the various cardiac structures, some two-dimensional systems, which displays the heart by constructing a plane image composed of many straight lines have been perfected. The authors, using such a system, specify its principal technical and clinical aspects and comment from iconographics documents and from their experience with more than 100 explorations, its advantages.

Adolescent↗
PubMed1978

[A treatable condition: parietal rupture of the heart during the acute phase of myocardial infarct. Apropos of a further case treated successfully with surgery].

A man aged 62 had an unexpected anterior myocardial infarction, complicated during the thirteenth hour after onset by parietal rupture and consequent acute tamponnade. The diagnosis was confirmed by echocardiography and then by pericardial puncture which allowed enough time for an operation to be undertaken under extra-corporeal circulation. The infarct was resected together with the weakened area of rupture, and the quality of the patient's life has been maintained at an excellent level after one year.

Cardiac Surgical Procedures↗
PubMed1978

[Proteasic polyseritis: effects of intraperitoneal injections of collagenase, alone or together with the administration of trypsin].

The authors showed previously that the effusions of the experimental polyseritis after intraperitoneal injections of trypsin and elastase, go from peritoneum to the pleural cavities and never from thorax to the peritoneum. The intraperitoneal injections of collagenase or of collagenase and trypsin can also cause polyseritis in the rat; but more often they provoke heavy hemorrhagic lesions of the wall of the abdomen and the diaphragm. Perforations of the diaphragm were observed in 8 rats of 32, with in 6, a intrathoracic hernia of the liver or the stomach. After the intrapleural injection of collagenase or of collagenase and trypsin, hemorrhagic lesions were seen in the thorax, but not in the abdomen. These facts are a new proof for the transdiaphragmatic propagation of the proteasic solutions injected in the peritoneum.

Abdominal Muscles↗
PubMed1978

[Early surgical treatment of a septal perforation complicating a posterior infarct. Value of the diaphragmatic left ventricular approach].

The authors report the case of a 53 year old patient who required operation on the 5th day after postero-inferior myocardical infarction for a poorly tolerated perforation of the ventricular septum. In discussing this case, they recall that the results for surgical repair of septal perforations complicating myocardial infarction are poorer when the infarction is posterior than when it is anterior. They suggest that this difference in prognosis is in large part due to the customary use in postero-inferior infarcts, of the right transventricular approach, which does not allow the infarct to be resected at the same time as the septum is closed. They finish by recommending the systematic use of a diaphragmatic approach to the left ventricle, including resection of the infarct, for all cases of septal perforations with posterior infarction in which surgery is necessary.

Cardiac Catheterization↗
PubMed1978

Anatomic, clinical, and therapeutic features of acute cardiac rupture. Successful surgical management fourteen hours after myocardial infarction.

A 62-year-old man sustained an acute myocardial infarction complicated on the thirteen hour by left ventricular rupture and acute periocardial tamponade. Echocardiography confirmed the suspicion of intrapericardial fluid, and immediate pericardiocentesis improved the hemodynamic state for a period sufficient to permit preparation for operation. Resection of ruptured and necrotic anteroapical left ventricular myocardium with primary reconstruction was successfully accomplished with the aid of temporary extracorporeal circulation. The patient has remained well for 1 year after the operation. Anatomic, clinical, and therapeutic features of acute cardiac rupture are discussed.

Cardiac Tamponade↗
PubMed1977

[Rupture of the free wall of the left ventricle during myocardial infarct. Contribution of echocardiography to its diagnosis. Surgical cure].

Parietal rupture of heart is one of the most dramatic complications in the acute stage of myocardial infarction. Generally it is fatal within few seconds or minutes. The authors report a case of rupture of the left ventricle into the free pericardial cavity, occurred at the 13th hour of an anterior infarction and surgically repaired with favourable result. On this occasion they emphasize the contribution of echocardiography to the diagnosis of cardiac rupture and the exceptional complexion of this case, which, to their best knowledge, is the third to have survived left ventricular rupture associated with ischemic heart disease, more than two months.

Drainage↗
PubMed1977

[Familial mitral valve prolapse and syncopes caused by ventricular tachycardia].

The authors report the case of a female aged 40 who was subject to syncopal attacks, and had an apical end-systolic murmur. The presence of an idiopathic prolapse of the mitral valve was demonstrated, as well as the familial nature of the condition, and the fact that the syncopal attacks were caused by ventricular tachycardia, The case report is followed by a discussion of the cardiac arrhythmias which are likely to accompany this particular mitral lesion, the difficulties in treatment which arise, and finally the danger of sudden death by ventricular fibrillation inherent in this condition, a danger which it is stille difficult to quantify.

Adult↗