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Biomedical subjects

J Weglarz

Publications and source records attributed to J Weglarz.

8 recordsLinked to original sources
PubMed1999

DNA sequencing with positive and negative errors.

The problem addressed in this paper is concerned with DNA sequencing by hybridization. An algorithm is proposed that solves a computational phase of this approach in the presence of both positive and negative errors resulting from the hybridization experiment. No a priori knowledge of the nature and source of these errors is required. An extensive set of computational experiments showed that the algorithm behaves surprisingly well if only positive errors appear. The general case, where positive and negative errors occur, can be also solved satisfactorily for an error rate up to 10%.

Algorithms↗
PubMed1998

[Tuberculosis of the spine: diagnosis and treatment].

The diagnosis and treatment for tuberculosis of the spine, based on own material from years 1992-97 (CMKP Orthopedic Department, Otwock) is presented. One hundred twenty nine patients were treated in these years, 85 of them surgically. The disease appeared usually in 4th, 5th or 6th decade of life, two adjacent vertebral bodies within lower thoracic spine were involved. Contemporary surgical methods as well as approved antibacterial treatment protocols are presented. Twenty-five per cent patients displayed symptoms of neurological impairment, namely paresis or plegia of the lower extremities. Good results of treatment in 85% of cases and only 3% poor results prove efficiency of the management suggested.

Adult↗
PubMed1997

Sequential and parallel algorithms for DNA sequencing.

MOTIVATION: Reconstruction of the original DNA sequence in the sequencing by the hybridization approach (SBH) requires computational support due to a large number of possible combinations. One can notice a lack of algorithms admitting false-negative data and giving in addition all possible solutions. RESULTS: In this paper, a new method of sequencing has been proposed. An algorithm based on its idea (for the general case, when some data are missing, like in the real experiment) has been implemented and tested. Authentic DNA sequences have been used for testing. A parallel version of the algorithm has also been implemented and tested. The quality of the reconstruction is satisfactory for the library of oligonucleotides of length between 8 and 12, and 100, 200 and 300 bp long sequences. A way to a further decrease in the computation time is also suggested.

Algorithms↗
PubMed1989

Shock in patients treated in the General Clinic of Internal Diseases, the Medical Academy in Lublin in the years 1979-1988.

Shock is, as before, among one of the most serious pathologic states threatening patient's life in spite of considerable progress in its treatment in the recent ten years. The immediate causes of shock may be a decrease of cardiac output, increase of volume of vascular bed or interaction of them both. Decrease of cardiac output may result from defective heart ability to contract or decrease venous blood flow to the heart. Decrease of stroke volume and cardiac output result in defective blood flow through all tissues and lead to metabolic acidosis, whose intensity is decisive for prognosis.

Adult↗
PubMedDate not supplied

[Our experience with using amrinone in circulatory failure].

A study aimed at evaluating an effect of amrinone of blood circulation dynamics (cardiac output), using impedance ++rheography. The study involved patients with acute, congestive cardiac failure (NYHA III-IV degrees). Cardiac output was measured prior to and 3 and 24 hours following amrinone administration. A favourable effect of a 24-hour i.v. infusion of amrinone on blood circulation dynamics was confirmed. The drug proved to be proarrhythmic.

Aged↗